FimH as a mucosal adjuvant enhances persistent antibody response and protective efficacy of the anti-caries vaccine

A Nanoparticle-Based Anticaries Vaccine Enhances the Persistent Immune Response To Inhibit Streptococcus mutans and Prevent Caries

“…The results showed that the ZIF-8@PAc vaccine led to significantly higher levels of IgG and its subclasses and resulted in a Th2-biased immune response that was maintained at high levels throughout the vaccination period. In addition, the level of serum IgG titer was also higher than that using TLR agonists as an adjuvant ( 12 , 14 ). Based on this result, ZIF-8@PAc not only elicited a high level of PAc-specific IgG but also maintained this high level for immune protection.…”

“…Therefore, nontoxic derivatives or other bacterial components, which are commonly ligands of Toll-like receptors (TLRs), have been investigated in caries vaccines. FimH, an adhesin component of fimbriae from Salmonella enterica serovar Typhimurium, has been suggested and proven to be a promising adjuvant to promote immune responses via the TLR4-dependent signaling pathway and protect against caries ( 12 ). In addition, the flagellin protein derived from E. coli , a TLR5 agonist, has been specifically evaluated as an effective mucosal adjuvant for eliciting obvious mucosal and systemic immune responses ( 13 ).…”

KbvR mutant of Klebsiella pneumoniae affects the synthesis of type 1 fimbriae and provides protection to mice as a live attenuated vaccine

“…The highly conserved fimbriae components have been generally shown to be promising candidates for inclusion in vaccines [ 40 – 42 ]. In addition, the structural proteins of type 1 fimbriae have been confirmed as effective protein carriers and immunogens in conjugates [ 43 , 44 ]. Overall, the maintained CPS and the increased synthesis of type 1 fimbriae made Δ kbvR strain a promising live attenuated vaccine that can provide broad antigen exposure and serve as intrinsic adjuvant properties to prime durable immune responses.…”