The purpose of this study was to evaluate the color changes of feldspathic ceramics CEREC Blocs (Dentsply Sirona, Milford, DE, USA) when cemented with different luting agents, while varying the ceramic thickness. Seventy ceramic discs of feldspathic ceramic (A2 shade) were obtained with 0.5 and 0.8 mm thicknesses. Seventy composite discs (A3 shade) 1 mm in thickness were used as substrates. After being polished and conditioned, the ceramic and composite discs were cemented with different resin cements and a flowable composite: Variolink® Esthetic Light, Neutral and Warm (Ivoclar Vivadent, Schaan, Liechtenstein); RelyXTM Veneer B0.5, Translucent and A3 Opaque/yellow shades (3M Oral Care, St. Paul, MN, USA); G-aenial® Universal Flow A2 (GC Europe, Leuven, Belgium). Color difference (ΔE) was determined using a spectrophotometer. A two-way ANOVA and multiple comparisons were performed using the Bonferroni method with a 95% confidence interval. Variolink® Neutral showed the highest ΔE (15.12 ± 0.71) and RelyXTM Veneer A3 the lowest value (1.59 ± 0.33). There are no statistically significant differences between the two ceramic thicknesses for Variolink® Light (p = 0.230) and RelyXTM Veneer B0.5 (p = 0.318) cements. The feldspathic ceramic final color is influenced by the cement used and the ceramic thickness. The use of different cements in a thin ceramic has a clinically significant impact on the final esthetic result.