2023
DOI: 10.26434/chemrxiv-2023-5k2tg
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Finding for New Drugs in Nature for Neglected Tropical Diseases: In Silico Study of Homolycorine Alkaloids against Chagas Disease

Daniel Mora,
Frederick Schosinsky,
Josue Castellón
et al.

Abstract: Chagas disease or American trypanosomiasis is a neglected tropical disease (NTD). It is mainly caused by infection with the Trypanosoma cruzi parasite. In this study, part of an Ibero-American project of a CYTED network devoted to the use of Amaryllidaceae alkaloids as templates for the synthesis of new pharmaceuticals, we have performed a virtual screening of homolycorine-type alkaloids where two alkaloids, 10-Norneronine and 2,10b-dihydroxy-9-O-demethylhomolycorine, can be the basis for the design of new d… Show more

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