Finding the groove: The groove sign in scleroderma and related disorders

Gleich syndrome and eosinophilic fasciitis overlap successfully treated with mepolizumab

“…Whereas eosinophilia, edemas, and hyperimmunoglobulinemia are features of both diseases, periodic urticarial lesions, weight gain, elevated IgE levels, and gastrointestinal manifestations indicate GS 1 . By contrast, the groove sign, 6 peau d'orange ‐like lesions, and particularly abundance of eosinophilic infiltrates in the fascia and muscle are characteristic features of EF. However, we did not find clinical or histopathological evidence for fibrosis/sclerosis which is usually found in longer‐standing EF.…”