FinDonor 10 000 study: a cohort to identify iron depletion and factors affecting it in Finnish blood donors

Lobier, Muriel; Niittymäki, Pia; Nikiforow, Nina; Palokangas, Elina; Larjo, Antti; Mattila, Pirkko; Castrén, Johanna; Partanen, Jukka; Arvas, Mikko

doi:10.1111/vox.12856

Cited by 16 publications

(23 citation statements)

References 32 publications

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“…Most publications on donation history include figures such as average donations per donor per year but they do not include tables of actual donation frequency that would allow us to answer the question. Reports from Iran, Burkina Faso, and Finland do point to low donation frequencies in all three countries, so the problem is certainly not confined to China and Brazil 16–18 . The frequency of single donations, however, is only one measure of the need for the approach investigated in this report.…”

Section: Discussionmentioning

confidence: 80%

Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency

et al. 2020

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Background The standard approach to estimating HIV incidence in repeat blood donors includes only donors who made two or more donations in an estimation interval. In China and some other countries, large proportions of repeat donors donate only once in a 1‐ or 2‐year interval. The standard approach may not represent risk among all repeat donors in these areas. Two approaches to including all repeat donors in the incidence estimate were evaluated in a simulation study. Study Design and Methods Under one approach, a donor infected at the first donation contributes a partial case to incidence that equals the proportion of time since the preceding donation that is in the estimation interval. Under the other, that donor contributes a full case if at least half the time since the previous donation is in the estimation interval and nothing otherwise. Infections identified at the second or subsequent donations in the interval contribute full cases as usual. The simulations involved proportions with single donations of 11% to 65% combined with a variety of patterns of rising, falling, or constant incidence. Results The partial‐case approach was unbiased under more test conditions than the whole‐case approach and exhibited smaller bias when both were biased. Under both approaches, bias >10% occurred only when rates of single donations >50% were combined with large changes in incidence over time. Conclusion The partial‐case approach performed better than the whole‐case approach. The conditions producing bias >10% are so extreme that they are unlikely to be encountered in the field.

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Section: Discussionmentioning

confidence: 80%

Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency

et al. 2020

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“…The findings from this survey provide support for Lifeblood to embark on large‐scale studies, including the establishment of associated biobanks aimed at improving the understanding of donor health and behavior, transfusion risk, and various aspects of quality and safety of donated blood products. As demonstrated by other blood donor cohorts that have been established elsewhere in the world, 1,3,4,6 such studies can be used as multipurpose resources for research addressing broader health questions in the Australian population.…”

Section: Discussionmentioning

confidence: 99%

“…Evidence generated from these cohorts regarding donor health and behavior, such as reducing low‐iron related deferrals and improving donor return rates, is being used to inform decision‐making by blood collection agencies in those countries. Data collected from these cohorts also contribute to health and medical research that is not directly related to blood donation, but that may improve the health of the population more generally 1,3,4 …”

Section: Introductionmentioning

confidence: 99%

“…Several countries such as Germany, 2 Denmark, 1 the Netherlands, 3 and Finland 4 are already generating important findings from research on their established blood donor cohorts. Evidence generated from these cohorts regarding donor health and behavior, such as reducing low‐iron related deferrals and improving donor return rates, is being used to inform decision‐making by blood collection agencies in those countries.…”

Section: Introductionmentioning

confidence: 99%

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Willingness of blood donors in Australia to provide additional data and blood sample for health research

et al. 2021

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Background Many blood collection agencies are generating important data on donor health outcomes using large‐scale blood donor cohort studies. Such studies can be very effective when donors provide access to linkage of their data to external health databases, and storage and genomic testing of their blood sample. In this study, we aimed to assess the willingness of Australian blood donors to provide additional data and blood sample for donation‐related and other health research. Study design and methods We invited 2017 donors to complete a survey using four methods (postal letter, postal letter and email, email only, and in‐center recruitment). The survey asked for information on demographics, lifestyle behaviors, health, experience and attitude to blood donation, and willingness to give blood sample and additional data for research. Results Response rates ranged from 23.8% for email only to 77.2% for in‐center recruitment. Of those who responded (n = 827), 95.5% indicated they would be willing to provide a blood sample for donation and transfusion‐related research. Of these, >90.0% were willing for their sample to be used in research involving genetic testing and other health‐related topics. Also, >90.0% were willing to consent for linkage of their information to external health databases. Conclusions Donors surveyed reported a high willingness to participate in health research by completing surveys, allowing linkage to external datasets, and providing a blood sample. These findings provide strong support for future longitudinal research studies with Australian blood donors.

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“…The Finnish Red Cross Blood Service (FRCBS) set up the FinDonor 10 000 study in 2015 [21] to investigate the health effects of blood donation with a specific focus on iron status [11]. In the present study, we test if worsening of self‐rated health of blood donors during the study period was associated with donation activity, biomarkers for iron levels or self‐reported changes in lifestyle.…”

Section: Introductionmentioning

confidence: 99%

Low ferritin levels appear to be associated with worsened health in male repeat blood donors

et al. 2021

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Background and objectives Frequent blood donation depletes iron stores of blood donors. Iron depletion may lead to anaemia, but the health effects of iron depletion without anaemia in healthy blood donors are not well understood. We studied in the FinDonor cohort whether worsening of self‐rated health of blood donors during the study period was associated with biomarkers for iron levels or other self‐reported changes in lifestyle. Materials and methods We included 1416 participants from the cohort who answered an 89‐item questionnaire on their health and lifestyle during their enrolment visit and again at the end of the study. We performed multivariate logistic regression to test if blood donation‐related factors affected the probability of reporting worsened health. To set these findings into a more holistic context of health, we subsequently analysed all other questionnaire items with a data‐driven exploratory analysis. Results We found that donation frequency in men and post‐menopausal women and ferritin level only in men was associated negatively with worsened health between questionnaires. In the exploratory analysis, stable physical condition was the only questionnaire item that was associated negatively with worsened health in both women and men. Conclusion Our results suggest that low ferritin level is associated with worsened health even in non‐anaemic repeat donors, although we find that when health is analysed more holistically, ferritin and other factors primarily related to blood donation lose their importance.

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FinDonor 10 000 study: a cohort to identify iron depletion and factors affecting it in Finnish blood donors

Cited by 16 publications

References 32 publications

Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency

Estimating the incidence of HIV infection in repeat blood donors with low average donation frequency

Willingness of blood donors in Australia to provide additional data and blood sample for health research

Low ferritin levels appear to be associated with worsened health in male repeat blood donors

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