Fine needle aspiration in studies of thyroglobulin (Tg). Iodothyronine and iodine contents of Tg from patients with multinodular euthyroid goitre

Laurberg, Peter; Sørensen, B. H.

doi:10.3109/00365518609083677

Cited by 9 publications

(3 citation statements)

References 7 publications

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“…The TG content within the thyroid gland may affect the serum TG level, and the total amount of TG in the thyroid tissue of patients with nontoxic multinodular goiter has been found to be higher than that in normal subjects (28). However, at present there are no data concerning the TG content in the thyroid tissue of acromegalic patients.…”

Section: Discussionmentioning

confidence: 95%

Thyroid Volume and Serum Thyroglobulin Levels in Patients with Acromegaly: Correlation with Plasma Insulin-Like Growth Factor I Levels*

Miyakawa

Saji

Tsushima

et al. 1988

The Journal of Clinical Endocrinology & Metabolism

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The pathogenesis of the goiter that is frequently found in patients with acromegaly is not known. Using ultrasonic scanning, we measured thyroid volume in 17 euthyroid patients with acromegaly and examined the relationships among thyroid size, plasma GH and insulin-like growth factor (IGF-I) levels, and serum thyroglobulin (TG) levels. The mean estimated thyroid volume in these 17 patients was 32.8 +/- 15.5 (+/- SD) mL, significantly larger than that in normal subjects (15.4 +/- 3.1 mL), and 64.7% of the patients had multinodular goiter, as identified by ultrasonography. Thyroid volume was positively correlated with plasma GH and IGF-I levels and heel-pad thickness, but not with the serum TSH level. In 7 patients, thyroid volume decreased in association with a decline in plasma GH and IGF-I levels after surgical treatment. The serum TG level was elevated in 7 of the 15 patients in whom it was measured, and the mean value was 51.7 +/- 62.7 (+/- SD) micrograms/L (normal, 12.6 +/- 6.4 micrograms/L). We found no correlations among the serum TG and TSH levels, plasma GH and IGF-I concentrations, and/or thyroid volume. However, serum TG decreased after surgical treatment, just as did plasma IGF-I. These observations together with the results of recent in vitro studies by others suggest that IGF-I is one of the factors involved in goiter formation, but the elevated serum TG levels in acromegaly are controlled not only by IGF-I but also by other factors.

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Section: Discussionmentioning

confidence: 95%

Thyroid Volume and Serum Thyroglobulin Levels in Patients with Acromegaly: Correlation with Plasma Insulin-Like Growth Factor I Levels*

Miyakawa

Saji

Tsushima

et al. 1988

The Journal of Clinical Endocrinology & Metabolism

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“…The mechanisms leading to this abnormality with multifocal polyclonal autonomous thyroid growth and function are only partly known. The abnormality is associated with and may be driven by a low organic iodine content of the thyroid gland (56,57). Some of the hyperfunctioning areas are monoclonal neoplasias harboring the same TSH-receptor activating point mutations as solitary toxic thyroid nodules (58)(59)(60).…”

Section: Mechanisms Behind the High Prevalence Of Low Serum Tsh In MImentioning

confidence: 99%

Environmental Iodine Intake Affects the Type of Nonmalignant Thyroid Disease

Laurberg¹,

Pedersen²,

Knudsen³

et al. 2001

Thyroid

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263

162

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The relationship between the iodine intake level of a population and the occurrence of thyroid diseases is U-shaped with an increase in risk from both low and high iodine intakes. Developmental brain disorders and endemic goiter caused by severe iodine deficiency may seriously deteriorate overall health status and economic performance of a population. Severe iodine deficiency with a median 24-hour urinary iodine excretion of the population below 25 microg needs immediate attention and correction. Less severe iodine deficiency with median urinary iodine excretion below 120 microg per 24 hours is associated with multinodular autonomous growth and function of the thyroid gland leading to goiter and hyperthyroidism in middle aged and elderly subjects. The lower the iodine intake, the earlier and more prominent are the abnormalities. At the other end of the spectrum, severely excessive iodine intake starting at median urinary iodine excretion levels around 800 microg per 24 hours is associated with a higher prevalence of thyroid hypofunction and goiter in children. A number of studies indicate that moderate and mild iodine excess (median urinary iodine >220 microg per 24 hours) are associated with a more frequent occurrence of hypothyroidism, especially in elderly subjects. The exact mechanism leading to this has not been clarified, and more studies are needed to define the limits of excessive iodine intake precisely. Due to the frequent occurrence of thyroid disorders, proper monitoring and control of the population iodine intake level is a cost-effective alternative to diagnosing, therapy and control of the many individual cases of thyroid diseases that might have been prevented.

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“…Moreover, enhancement of intrathyroidal iodine deficiency caused by the high thyroidal hormone production and turnover may play a role (40). High T 3 content of thyroglobulin (41) and high thyroidal type I iodothyronine deiodinase activity (23) may also be the major mechanisms behind the relatively high serum T 3 in nodular thyroid disease.…”

Section: Pathophysiological Mechanismsmentioning

confidence: 99%

Determinants of serum T4 and T3 at the time of diagnosis in nosological types of thyrotoxicosis: a population-based study

Carlé

Knudsen

Pedersen

et al. 2013

European Journal of Endocrinology

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Fine needle aspiration in studies of thyroglobulin (Tg). Iodothyronine and iodine contents of Tg from patients with multinodular euthyroid goitre

Cited by 9 publications

References 7 publications

Thyroid Volume and Serum Thyroglobulin Levels in Patients with Acromegaly: Correlation with Plasma Insulin-Like Growth Factor I Levels*

Thyroid Volume and Serum Thyroglobulin Levels in Patients with Acromegaly: Correlation with Plasma Insulin-Like Growth Factor I Levels*

Environmental Iodine Intake Affects the Type of Nonmalignant Thyroid Disease

Determinants of serum T4 and T3 at the time of diagnosis in nosological types of thyrotoxicosis: a population-based study

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