Fine Needle Aspiration of the Thyroid: A Contemporary Experience of 3981 Cases

Coorough, Nicholas; Hudak, Kevin; Buehler, Darya; Selvaggi, Suzanne M.; Sippel, Rebecca S.; Chen, Herbert

doi:10.1016/j.jss.2011.02.048

Cited by 16 publications

(14 citation statements)

References 20 publications

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“…The rate of benign FNAs in our population (87.5%) is higher than the 60–70% rate cited in the literature (4, 15). However, as shown in a previous study at our institution (13), this can probably be explained by the increase in the number of benign nodules meeting ATA criteria for biopsy in recent years due to increased detection of nodules through imaging and increases in biopsies of multiple nodules in a multi-nodular goiter (12, 14). Our rate of non-diagnostic FNA results (6.5%) was lower than that reported in some series and reviews which report rates of 15–20% of non-diagnostic FNAs (10, 15, 16).…”

Section: Discussionmentioning

confidence: 74%

“…Diagnostic FNAs were first classified into groupings based on a modification of the Bethesda System for Reporting Thyroid Cytopathology (13, 14). These groupings were then more broadly classified as benign, indeterminate, or malignant.…”

Section: Methodsmentioning

confidence: 99%

“…This rise in technology has increased the number of FNA biopsies, and has changed the patient population undergoing FNA at our institution. As a result, the overall number of patients undergoing FNA at our institution has risen significantly (13). …”

Section: Introductionmentioning

confidence: 99%

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The incidence of thyroid cancer by f ine needle aspiration varies by age and gender

Bessey

Lai

Coorough

et al. 2013

Journal of Surgical Research

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Background Fine needle aspiration (FNA) is the standard to evaluate thyroid nodules for malignancy. The aim of this study was to determine the influence of patient age and gender on the rate of thyroid nodule malignancy by FNA. Methods A database of 3,981 consecutive patients who underwent thyroid FNA between 2002 and 2009 was reviewed. The percentages of benign, indeterminate, and malignant biopsies based on patient age and gender were determined. Statistical analysis was performed using SPSS. Results Our patient population included 2,766 women (mean age ± SD, 52 ± 15.2) and 964 men (mean age ± SD, 59 ± 13.8). Of the 3,722 (93.5%) patients with diagnostic FNAs, 196 (5.3%) had malignant FNA cytology. Malignant FNAs were twice as frequent in patients age ≤45 vs. those >45 (8.1% vs. 4.0%, p<0.001). Overall, men had more indeterminate (10.2% vs. 6.3%, p<0.001) and malignant (6.7% vs. 4.8%, p=0.034) FNAs than women. Malignant FNAs in men were greatest in patients over age 45 (6.0% vs. 3.2%, p=0.001). The incidence of malignant FNAs for women peaked in their 30s (10.4%) whereas the incidence of malignant FNAs for men peaked 10 years later in their 40s (12.1%). Both men and women had the lowest incidence of malignant FNAs in their 70s (2.3% and 1.9% respectively). Conclusion The typical 5% risk of thyroid nodule malignancy on FNA varies depending on patient age and gender. A patient’s age and gender should therefore be considered when counseling someone of their risk of thyroid cancer by FNA.

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Section: Discussionmentioning

confidence: 74%

Section: Methodsmentioning

confidence: 99%

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The incidence of thyroid cancer by f ine needle aspiration varies by age and gender

Bessey

Lai

Coorough

et al. 2013

Journal of Surgical Research

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“…Conflicting guidelines result in highly variable practices 1 2. Some argue that thyroid fine-needle aspiration (FNA) carries minimal risk and provides definitive pathology results; however, benign thyroid nodules are common and an increasing number of thyroid biopsies in the USA result in a costly problem for the healthcare system 3. Furthermore, for one-third of patients’ workup does not end with FNA; cytology results can lead to repeat biopsies and even diagnostic lobectomy 4.…”

Section: Contextmentioning

confidence: 99%