Fine particulate matter constituents and sub-clinical outcomes of cardiovascular diseases: A multi-center study in China

Du, Xihao; Zhang, Yi; Liu, Cong; Fang, Jianlong; Zhao, Feng; Chen, Chen; Du, Peng; Wang, Qiong; Wang, Jiaonan; Shi, Wanying; Donkelaar, Aaron van; Martin, Randall V.; Bachwenkizi, Jovine; Chen, Renjie; Li, Tiantian; Kan, Haidong; Shi, Xiaoming

doi:10.1016/j.scitotenv.2020.143555

Cited by 39 publications

(18 citation statements)

References 27 publications

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“…Our findings were also supported by previous studies quantifying the impacts of PM 2.5 constituents on certain components of MetS. ,, For example, a study in China showed that PM 2.5 organic matter was positively associated with GLU, while NO 3 – , NH 4 + , and organic matter were associated with increased DBP levels . Another study in elderly Koreans showed that NH 4 + and SO 4 2– constituents were positively associated with BP .…”

Section: Discussionsupporting

confidence: 90%

“…21,43,44 For example, a study in China showed that PM 2.5 organic matter was positively associated with GLU, while NO 3 − , NH 4 + , and organic matter were associated with increased DBP levels. 43 Another study in elderly Koreans showed that NH 4 + and SO 4 2− constituents were positively associated with BP. 44 Besides, central obesity was reported to aggravate the effects of polycyclic aromatic hydrocarbon [PAH (belongs to OC)] exposure on diabetes.…”

Section: Discussionmentioning

confidence: 99%

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Associations of Fine Particulate Matter Constituents with Metabolic Syndrome and the Mediating Role of Apolipoprotein B: A Multicenter Study in Middle-Aged and Elderly Chinese Adults

Zhao

Pan

et al. 2022

Environ. Sci. Technol.

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Fine particulate matter (PM2.5) was reported to be associated with metabolic syndrome (MetS), but how PM2.5 constituents affect MetS and the underlying mediators remains unclear. We aimed to investigate the associations of long-term exposure to 24 kinds of PM2.5 constituents with MetS (defined by five indicators) in middle-aged and elderly adults and to further explore the potential mediating role of apolipoprotein B (ApoB). A multicenter study was conducted by recruiting subjects (n = 2045) in the Beijing-Tianjin-Hebei region from the cohort of Sub-Clinical Outcomes of Polluted Air in China (SCOPA-China Cohort). Relationships among PM2.5 constituents, serum ApoB levels, and MetS were estimated by multiple logistic/linear regression models. Mediation analysis quantified the role of ApoB in “PM2.5 constituents-MetS” associations. Results indicated PM2.5 was significantly related to elevated MetS prevalence. The MetS odds increased after exposure to sulfate (SO4 2–), calcium ion (Ca2+), magnesium ion (Mg2+), Si, Zn, Ca, Mn, Ba, Cu, As, Cr, Ni, or Se (odds ratios ranged from 1.103 to 3.025 per interquartile range increase in each constituent). PM2.5 and some constituents (SO4 2–, Ca2+, Mg2+, Ca, and As) were positively related to serum ApoB levels. ApoB mediated 22.10% of the association between PM2.5 and MetS. Besides, ApoB mediated 24.59%, 50.17%, 12.70%, and 9.63% of the associations of SO4 2–, Ca2+, Ca, and As with MetS, respectively. Our findings suggest that ApoB partially mediates relationships between PM2.5 constituents and MetS risk in China.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 99%

Associations of Fine Particulate Matter Constituents with Metabolic Syndrome and the Mediating Role of Apolipoprotein B: A Multicenter Study in Middle-Aged and Elderly Chinese Adults

Zhao

Pan

et al. 2022

Environ. Sci. Technol.

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“…Specifically, air pollution has a negative influence on health as the poor environment quality causes illnesses. Previous studies ( 53 , 54 ) indicated that air pollution is one of the main causes that increase the mortality and morbidity of cardiovascular disease. Thus, the worse the quality of the environment, the more tangible and intangible costs that residents should pay, including healthcare expenditure and health outcomes.…”

Section: Discussionmentioning

confidence: 99%

Transportation, Environmental Degradation, and Health Dynamics in the United States and China: Evidence From Bootstrap ARDL With a Fourier Function

Lin

2022

Front. Public Health

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Transportation and environmental degradation, with indirect and direct effects, play a significant role in determining the health of a nation's citizens. This study uses bootstrap ARDL with a Fourier function to examine transportation, environmental degradation, and health dynamics in the United States and China. In the long run, the results support the cointegration relationship between transportation, environmental degradation, and health in both countries. The results show the contingency of the causality where a negative impact of transportation on environmental degradation exists in the United States while a positive impact exists in China. The effect of environmental degradation on health is negative in the United States while a positive effect exists in China. Regarding the causal direction between the variables of interest, the implications provide policymakers in developing strategy and policy for sustainable development.

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“…Before a formal diagnosis of diabetes, impaired FBG can be hazardous . There are several risk factors for diabetes and/or high FBG levels such as age, race/ethnicity, obesity, lack of exercise, unhealthy dietary habits, and the potential effects of environmental factors like air pollution. , Several past studies investigated the association of exposure to air pollution, such as SO 2 , NO x , and PM 2.5 (fine particular matter with aerodynamic diameters ≤ 2.5 μm), with FBG/diabetes. , Exposure to PM 2.5 was found to be associated with higher FBG in some studies, − but not consistently significant in all cases. Most of the available studies explored the effects of bulk PM 2.5 on diabetes, while few evaluated the impacts of PM 2.5 constituents.…”

Section: Introductionmentioning

confidence: 99%

“…Most of the available studies explored the effects of bulk PM 2.5 on diabetes, while few evaluated the impacts of PM 2.5 constituents. PM 2.5 contains hundreds of components with distinct physiological characteristics. , There are very limited studies to date examining the associations of PM 2.5 constituents with diabetes or FBG levels, and a handful of studies available are mainly in susceptive groups such as pregnancy and newborns. , A national survey of exposure to PM 2.5 constituents with subclinical outcomes of cardiovascular disease found that FBG was positively associated with OM, BC, SO 4 2– , NO 3 – , and NH 4 + . Robledo et al.…”

Section: Introductionmentioning

confidence: 99%

Linking the Fasting Blood Glucose Level to Short-Term-Exposed Particulate Constituents and Pollution Sources: Results from a Multicenter Cross-Sectional Study in China

Yanlin

Fang

Wang

et al. 2022

Environ. Sci. Technol.

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Ambient PM2.5 (fine particulate matter with aerodynamic diameters ≤ 2.5 μm) is thought to be associated with the development of diabetes, but few studies traced the effects of PM2.5 components and pollution sources on the change in the fasting blood glucose (FBG). In the present study, we assessed the associations of PM2.5 constituents and their sources with the FBG in a general Chinese population aged over 40 years. Exposure to PM2.5 was positively associated with the FBG level, and each interquartile range (IQR) increase in a lag period of 30 days (18.4 μg/m3) showed the strongest association with an elevated FBG of 0.16 mmol/L (95% confidence interval: 0.04, 0.28). Among various constituents, increases in exposed elemental carbon, organic matter, arsenic, and heavy metals such as silver, cadmium, lead, and zinc were associated with higher FBG, whereas barium and chromium were associated with lower FBG levels. The elevated FBG level was closely associated with the PM2.5 from coal combustion, industrial sources, and vehicle emissions, while the association with secondary sources was statistically insignificant. Improving air quality by tracing back to the pollution sources would help to develop well-directed policies to protect human health.

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Fine particulate matter constituents and sub-clinical outcomes of cardiovascular diseases: A multi-center study in China

Cited by 39 publications

References 27 publications

Associations of Fine Particulate Matter Constituents with Metabolic Syndrome and the Mediating Role of Apolipoprotein B: A Multicenter Study in Middle-Aged and Elderly Chinese Adults

Associations of Fine Particulate Matter Constituents with Metabolic Syndrome and the Mediating Role of Apolipoprotein B: A Multicenter Study in Middle-Aged and Elderly Chinese Adults

Transportation, Environmental Degradation, and Health Dynamics in the United States and China: Evidence From Bootstrap ARDL With a Fourier Function

Linking the Fasting Blood Glucose Level to Short-Term-Exposed Particulate Constituents and Pollution Sources: Results from a Multicenter Cross-Sectional Study in China

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