Fine particulate matter measured by satellites predicts the risk of age-related macular degeneration in a longitudinal cohort study

Liang, Chih‐Ming; Wang, Chi-Min; Jung, Chau-Ren; Chang, Yun‐Ting; Lin, Che Tong; Lin, Yu-Ting; Hwang, Bing‐Fang

doi:10.1007/s11356-022-19278-9

Cited by 13 publications

(25 citation statements)

References 41 publications

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“…The association of PM 2.5 with AMD in the present investigation was consistent with other studies, such as the UK Biobank study [ 15 ], the Canadian Longitudinal Study [ 16 ], and a study in Taiwan [ 14 ]. The potential mechanisms underlying the effects of air pollution on AMD involve three aspects.…”

Section: Discussionsupporting

confidence: 92%

“…These results warrant attention in prospective cohort and mechanistic studies to further elucidate the relationship between meteorological factors, air pollution, and degenerative eye disease. The association of PM 2.5 with AMD in the present investigation was consistent with other studies, such as the UK Biobank study [15], the Canadian Longitudinal Study [16], and a study in Taiwan [14]. The potential mechanisms underlying the effects of air pollution on AMD involve three aspects.…”

Section: Discussionsupporting

confidence: 91%

“…First, PM 2.5 can impair microvascular function. Dysfunction of the microcirculation can lead to age-related diseases, including stroke and AMD, and insufficient microcirculation can promote oxidative stress and inflammatory processes [ 14 , 33 ]. Second, PM 2.5 is linked to poor retinal structure, which may lead to AMD [ 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

“…Risk factors for AMD include interactions between genetic and environmental factors. Recent studies have suggested that air pollution is a potential risk factor for AMD [ 13 , 14 ]. According to the UK Biobank study, PM 2.5 is associated with self-reported AMD in participants ages 40–69 [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

“…In the Canadian Longitudinal Study, increased PM 2.5 levels were associated with visual impairments from AMD in the single pollutant model [ 16 ]. In a study in Taiwan, AMD risk increased by 19% for every 10 µg/m 3 increase in PM 2.5 [ 14 ]. Air pollution has been shown to decrease axoplasmic transport in the optic nerve.…”

Section: Introductionmentioning

confidence: 99%

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Joint effects of meteorological factors and PM<sub>2.5</sub> on age-related macular degeneration: a national cross-sectional study in China

Liu

et al. 2023

Environ. Health Prev. Med.

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Background: Weather conditions are a possible contributing factor to age-related macular degeneration (AMD), a leading cause of irreversible loss of vision. The present study evaluated the joint effects of meteorological factors and fine particulate matter (PM 2.5 ) on AMD. Methods: Data was extracted from a national cross-sectional survey conducted across 10 provinces in rural China. A total of 36,081 participants aged 40 and older were recruited. AMD was diagnosed clinically by slit-lamp ophthalmoscopy, fundus photography, and spectral domain optical coherence tomography (OCT). Meteorological data were calculated by European Centre for Medium-Range Weather Forecasts (ECMWF) reanalysis and were matched to participants' home addresses by latitude and longitude. Participants' individual PM 2.5 exposure concentrations were calculated by a satellite-based model at a 1-km resolution level. Multivariable-adjusted logistic regression models paired with interaction analysis were performed to investigate the joint effects of meteorological factors and PM 2.5 on AMD. Results: The prevalence of AMD in the study population was 2.6% (95% CI 2.42-2.76%). The average annual PM 2.5 level during the study period was 63.1 « 15.3 µg/m 3 . A significant positive association was detected between AMD and PM 2.5 level, temperature (T), and relative humidity (RH), in both the independent and the combined effect models. For PM 2.5 , compared with the lowest quartile, the odds ratios (ORs) with 95% confidence intervals (CIs) across increasing quartiles were 0.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Joint effects of meteorological factors and PM<sub>2.5</sub> on age-related macular degeneration: a national cross-sectional study in China

Liu

et al. 2023

Environ. Health Prev. Med.

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Nighttime Outdoor Artificial Light and Risk of Age-Related Macular Degeneration

Kim,

Shin

et al. 2024

JAMA Netw Open

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ImportanceLight pollution’s impact on human health is increasingly recognized, but its link to exudative age-related macular degeneration (EAMD) remains unclear.ObjectiveTo investigate the association between exposure to outdoor artificial light at night (OALAN) and the risk of incident EAMD.Design, Setting, and ParticipantsIn this nationwide population-based case-control study, all individuals 50 years or older with newly diagnosed EAMD between January 1, 2010, and December 31, 2011, were identified with reference to the Korean National Health Insurance Service registration program database for rare and intractable diseases. Birth year– and sex-matched controls (with no EAMD diagnosis until 2020) were selected at a 1:30 ratio. Data were acquired from May 1 to December 31, 2021, and analyzed from June 1 to November 30, 2022.ExposuresMean levels of OALAN at participants’ residential addresses during 2008 and 2009 were estimated using time-varying satellite data for a composite view of persistent nighttime illumination at an approximate scale of 1 km2.Main Outcomes and MeasuresThe hazard ratios (HRs) and 95% CIs of the association between residential OALAN and risk of incident EAMD were determined based on maximum likelihood estimation after adjusting for sociodemographic characteristics, comorbidities, and area-level risk factors (ie, nighttime traffic noise and particulate matter of aerodynamic diameter ≤10 μm in each participant’s administrative district of residence).ResultsA total of 126 418 participants were included in the analysis (mean [SD] age, 66.0 [7.9] years; 78 244 men [61.9%]). Of these, 4078 were patients with newly diagnosed EAMD and 122 340 were EAMD-free matched controls. In fully adjusted models, an IQR (55.8 nW/cm2/sr) increase in OALAN level was associated with an HR of 1.67 (95% CI, 1.56-1.78) for incident EAMD. The exposure-response curve demonstrated a nonlinear, concave upward slope becoming more pronounced at higher levels of light exposure (ie, at approximately 110 nW/cm2/sr). In a subgroup analysis, an IQR increase in OALAN was associated with increased risk of incident EAMD in urban areas (HR, 1.46 [95% CI, 1.33-1.61]) but not in rural areas (HR, 1.01 [95% CI, 0.84-1.22]).Conclusions and RelevanceIn this nationwide population-based case-control study, higher levels of residential OALAN were associated with an increased risk of incident EAMD. Future studies with more detailed information on exposure, individual adaptive behaviors, and potential mediators are warranted.

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Klimawandel als Faktor bei der Entstehung von Netzhauterkrankungen: eine kritische Betrachtung

Jauch,

Ach

2024

Ophthalmologie

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Fine particulate matter measured by satellites predicts the risk of age-related macular degeneration in a longitudinal cohort study

Cited by 13 publications

References 41 publications

Joint effects of meteorological factors and PM<sub>2.5</sub> on age-related macular degeneration: a national cross-sectional study in China

Joint effects of meteorological factors and PM<sub>2.5</sub> on age-related macular degeneration: a national cross-sectional study in China

Nighttime Outdoor Artificial Light and Risk of Age-Related Macular Degeneration

Klimawandel als Faktor bei der Entstehung von Netzhauterkrankungen: eine kritische Betrachtung

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