Fine structure of nervous elements in the pancreas of some vertebrates

Watari, Nakazo

doi:10.1007/bf00328843

Cited by 109 publications

(32 citation statements)

References 26 publications

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“…A close relation between the islet endocrine cell and autonomic axons has repeatedly been reported in various mammals (BENCOSME, 1959;STAHL, 1963;LEGG, 1967;ESTERHUIZEN et al, 1968;WATARI, 1968;KOBAYASHI and FUJITA, 1969;WOODS and FORTE, 1974).…”

Section: Axon-islet Cell Relationshipsupporting

confidence: 59%

“…In the bat, dog and some other vertebrates, WATARI (1968WATARI ( , 1973 reported that nerve terminals in the islets were classifiable into four types by the fine structure of their synaptic vesicles. As these four types seem to correspond only partly to the four types demonstrated in the present study, it seems reasonable to propose that more than four types of nerve terminals might be present in the pancreas, representing the sites of different neurohumors.…”

Section: Synaptic Typesmentioning

confidence: 99%

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Proposal of a Neurosecretory System in the Pancreas

Fujita

Kobayashi

1979

Arch. Histol. Jap., Arch. Histol. Jpn

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Summary. The nerve fibers supplying the islets of the dog pancreas were examined by electron microscopy. Axons with swollen portions containing various types of synaptic vesicles, including a cholinergic type, two varieties of presumable aminergic type and a possible peptidergic type, rush to the pericapillary space to end there, whereas only a small part of them seem to terminate on the endocrine cells of the islet.Schwann cell cytoplasm invests the axons and often separates these from the endocrine cells. The terminal portions filled with vesicles usually become free of the Schwann sheath on the side facing the blood capillary. Here the neuronal secretions are believed to be released into the blood stream through the pored endothelium of the capillary.The neurosecretions, together with the islet hormones are distributed to the exocrine pancreas in high concentrations via the insulo-acinar portal system. It seems thus sufficient for the nerves to supply the islet in order to control the exocrine function of the pancreas.During the three decades since the establishment of the hypothalamo-hypophyseal neurosecretory system by BARGMANN (1949), the concept and criteria of neurosecretion have changed a great deal (LEDERIS, 1974;SANO, 1978). BARGMANN and SCHARRER (1951) regarded that stain-technologically demonstrable secretory granules are essential for a neurosecretory cell, but later this criterion had to be abandoned as newly discovered neurosecretory system producing and transporting releasing hormones from the hypothalamus to the hypophyseal portal vessels revealed no stainable granules. Recent advance in the knowledge of peptidergic neurons and of aminecontaining neurons occurring in different central and peripheral nervous tissues caused further confusion to the concept of neurosecretion. In agreement with SANO (1978), the last reliable criterion of neurosecretion (in higher vertebrates) must be that the neuronal secretions are released into the circulation and this is morphologically reflected in that the nerve terminals are not related to their target organ or cell but end in the perivascular (especially pericapillary) space.In the course of our electron microscope study of the dog pancreas, we recently noticed that numerous nerve terminals occur in the pericapillary spaces of the islet. Also by re-examining the electron micrographs which we produced for our previous *This paper is dedicated to the memory of the late Professor Wolfgang BARGMANN. 277

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Section: Axon-islet Cell Relationshipsupporting

confidence: 59%

Section: Synaptic Typesmentioning

confidence: 99%

Proposal of a Neurosecretory System in the Pancreas

Fujita

Kobayashi

1979

Arch. Histol. Jap., Arch. Histol. Jpn

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“…The innervation of the pancreatic islet by postganglionic adrenergic and cholinergic axon terminals, as well as by serotoninergic and VIP-immunoreactive fibers, has been extensively studied (for References see WATARI, 1968;WooDs and PoRTE, 1974;UNSICKER, 1984).…”

mentioning

confidence: 99%

Fine structure of the neuro-insular complex type II in the cat.

Böck

1986

Arch. Histol. Jap., Arch. Histol. Jpn

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“…The Journal of Clinical Investigation Volume 52 May 1973 1246-1259 cies receive an ample supply of autonomic nerve fibers (6)(7)(8)(9)(10)(11)(12); finally, from the nature of the metabolic effects of glucagon, particularly upon the liver, since potent stimulation of glycogenolysis and gluconeogenesis would seem appropriate in states of stress or physical exertion, states in which increased sympathetic activity is known to occur.…”

mentioning

confidence: 99%

Glucagon Release Induced by Pancreatic Nerve Stimulation in the Dog

Marliss¹,

Girardier²,

Seydoux³

et al. 1973

J. Clin. Invest.

130

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A B S T R A C T A direct neural role in the regulation of immunoreactive glucagon (IRG) secretion has been investigated during stimulation of mixed autonomic nerves to the pancreas in anesthetized dogs. The responses were evaluated by measurement of blood flow and hormone concentration in the venous effluent from the stimulated region of pancreas.Electrical stimulation of the distal end of the discrete bundles of nerve fibers isolated along the superior pancreaticoduodenal artery was invariably followed by an increase in IRG output. With 10-min periods of nerve stimulation, the integrated response showed that the higher the control glucagon output, the greater was the increment. Atropinization did not influence the response to stimulation. That the preparation behaved in physiologic fashion was confirmed by a fall in IRG output, and a rise in immunoreactive insulin (IRI) output, during hyperglycemia induced by intravenous glucose (0.1 g/kg). The kinetics of this glucose effect on IRG showed characteristics opposite to those of nerve stimulation: the lower the control output, the less the decrement. Furthermore, during the control steady state, blood glucose concentration was tightly correlated with the IRI/

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Fine structure of nervous elements in the pancreas of some vertebrates

Cited by 109 publications

References 26 publications

Proposal of a Neurosecretory System in the Pancreas

Proposal of a Neurosecretory System in the Pancreas

Fine structure of the neuro-insular complex type II in the cat.

Glucagon Release Induced by Pancreatic Nerve Stimulation in the Dog

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