Fine-tuning the sequential drug release of nano-formulated mutual prodrugs dictates the combination effects

Zhong, Haiping; Li, Xingwei; Yu, Na; Zhang, Xi; Mu, Jingqing; Liu, Tao; Yuan, Bo; Yuan, Xiaoyong; Guo, Shutao

doi:10.1039/d3sc00550j

Cited by 6 publications

(1 citation statement)

References 31 publications

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“…However, the combination of antibiofilm and animal experimental results confirmed that the increase in ALK environment played a synergistic antibiofilm effect and that the OCT/PECT@OCT + ALK was significantly superior to the OCT/PECT@OCT hydrogel. In addition, we believed that this composite antimicrobial profile may reduce the risk of developing bacterial resistance [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Thermosensitive hydrogel with programmed dual-octenidine release combating biofilm for the treatment of apical periodontitis

Cheng,

Huangfu,

Zhao

et al. 2024

Regenerative Biomaterials

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The utilization of intracanal medicaments is an indispensable procedure in root canal treatment（RCT）. However, the conventional intracanal medicaments still need improvement regarding antimicrobial efficacy and ease of clinical operation. To address the above issues, OCT/PECT@OCT+ALK composite hydrogel characterized by programming sequential release of dual antimicrobial agents has been proposed. Thanks to the self-assemble ability of amphiphilic copolymer poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro -9-undecanone)-poly(ethylene glycol)-poly(ε-caprolactone-co-1,4,8-trioxa [4.6]spiro-9- undecanone) (PECT), dual hydrophilic and hydrophobic antimicrobial agents could be easily encapsulated in the hydrogel system, and tailored for sequential drug release for a better antibiofilm effect. The hydrophilic octenidine (Octenidine dihydrochloride, OCT-HCl) is encapsulated in the hydrophilic part of hydrogel for instantaneous elevating the drug concentration through bursting release, and the hydrophobic octenidine(Octenidine, OCT) is further loaded into the PECT nanoparticles to achieve a slower and sustained release profile. Additionally, calcium hydroxide (Ca(OH)2) was incorporated into the system and evenly dispersed among PECT nanoparticles to create an alkaline (ALK) environment, synergistically enhancing the antibiofilm effect with higher efficiency and prolonged duration. The antibiofilm effect has been demonstrated in root-canal models and apical periodontitis rats, exhibiting superior performance compared to clinically used Ca(OH)2 paste. This study demonstrates that OCT/PECT@OCT+ALK composite thermosensitive hydrogel is a potential intracanal medicament with excellent antibiofilm effect and clinical operability.

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Section: Discussionmentioning

confidence: 99%

Thermosensitive hydrogel with programmed dual-octenidine release combating biofilm for the treatment of apical periodontitis

Cheng,

Huangfu,

Zhao

et al. 2024

Regenerative Biomaterials

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Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Chen,

Zhou,

Jia

et al. 2024

Acta Pharmaceutica Sinica B

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Multistage microfluidic assisted Co-Delivery platform for dual-agent facile sequential encapsulation

Li,

Yang,

et al. 2025

European Journal of Pharmaceutics and Biopharmaceutics

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Fine-tuning the sequential drug release of nano-formulated mutual prodrugs dictates the combination effects

Abstract: Nanoformulated mutual prodrugs able to release two drugs either in order or simultaneously which significantly affected the combination effects consistently in vitro and in vivo, and links the in vitro–in vivo optimization of therapeutic effects.

Cited by 6 publications

References 31 publications

Thermosensitive hydrogel with programmed dual-octenidine release combating biofilm for the treatment of apical periodontitis

Thermosensitive hydrogel with programmed dual-octenidine release combating biofilm for the treatment of apical periodontitis

Enhancing cancer immunotherapy: Nanotechnology-mediated immunotherapy overcoming immunosuppression

Multistage microfluidic assisted Co-Delivery platform for dual-agent facile sequential encapsulation

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