Finger or toe: the molecular basis of limb identity

Logan, Malcolm

doi:10.1242/dev.00956

Cited by 75 publications

(52 citation statements)

References 63 publications

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“…MDGA1 does not appear to be generally involved in this process, because some of the lumbar LMCm neurons apparently do not express MDGA1. However, it is still possible that MDGA1 might be required for the proper segregation of these motor neurons at the base of the forelimbs and at a specific choice point in the hindlimbs, since these limbs are differentially specified (Logan, 2003), and each plexus might face somewhat different circumstances.…”

Section: Discussionmentioning

confidence: 99%

MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains

Fujimura

Iwashita²,

Matsuzaki³

et al. 2006

Brain Research

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Section: Discussionmentioning

confidence: 99%

MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains

Fujimura

Iwashita²,

Matsuzaki³

et al. 2006

Brain Research

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“…Tbx4 and Tbx5 play a cardinal role in initiating limb outgrowth. Furthermore, Tbx5 is specifically expressed in the forelimb field and Tbx4 in the hindlimb, and the genes have been proposed to specify fore-vs. hindlimb identity (reviewed in Logan, 2003). This finding, however, is not supported by an elegant experiment leading to expression swapping between Tbx5 and Tbx4 in the forelimb (Minguillon et al, 2005).…”

Section: Role Of Tbx Genes In Specification Of More Posterior Identitymentioning

confidence: 99%

Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics

Robert

Lallemand

2006

Developmental Dynamics

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The limb has been a privileged object of investigation and reflection for scientists over the past two centuries and continues to provide a heuristic framework to analyze vertebrate development. Recently, accumulation of new data has significantly changed our view on the mechanisms of limb patterning, in particular along the anterior-posterior axis. These data have led us to revisit the mode of action of the zone of polarizing activity. They shed light on the molecular and cellular mechanisms of patterning linked to the Shh-Gli3 signaling pathway and give insights into the mechanism of activation of these cardinal factors, as well as the consequences of their activity. These new data are in good part the result of systematic Application of tools used in contemporary mouse molecular genetics. These have extended the power of mouse genetics by introducing mutational strategies that allow fine-tuned modulation of gene expression, interchromosomal deletions and duplication. They have even made the mouse embryo amenable to cell lineage analysis that used to be the realm of chick embryos. In this review, we focus on the data acquired over the last five years from the analysis of mouse limb development and discuss new perspectives opened by these results. Developmental Dynamics 235:2337-2352, 2006.

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“…Mutations in TBX5 are associated with Holt-Oram syndrome (HOS), a congenital disorder characterized by limb malformations, cardiac septal defects, and conduction system anomalies (Basson et al, 1997;Li et al, 1997). Consequently, the function of Tbx5 in the formation of the heart and limbs has been the subject of several investigations (Logan, 2003;Plageman and Yutzey, 2005). During development, tbx5 is expressed in the embryonic heart and forelimbs, suggesting that altered Tbx5 function at these locations underlies abnormal development (Chapman et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Microarray analysis of Tbx5‐induced genes expressed in the developing heart

Plageman

Yutzey

2006

Developmental Dynamics

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Tbx5 is a member of the T-box family of transcription factors and is associated with Holt-Oram syndrome (HOS), a congenital disorder characterized by heart and limb defects. Although implicated in several processes during development, only a few genes regulated by Tbx5 have been reported. To identify candidate genes regulated by Tbx5 during heart development, a microarray approach was used. A cardiacderived mouse cell line (1H) was infected with adenoviruses expressing Tbx5 or ␤-galactosidase and RNA was isolated for analysis using an Affymetrix gene chip representing over 39,000 transcripts. Real-time reverse transcriptase-polymerase chain reaction confirmed Tbx5 induction of a subset of the genes, including nppa, photoreceptor cadherin, brain creatine kinase, hairy/enhancer-of-split related 2, and gelsolin. In situ hybridization analysis indicated overlapping expression of these genes with tbx5 in the embryonic mouse heart. In addition, the effect of HOS-associated mutations on the ability of Tbx5 to induce target gene expression was evaluated. Together, these data identify several genes induced by Tbx5 that are potentially important during cardiac development. These genes represent new candidate gene targets of Tbx5 that may be related to congenital heart malformations associated with HOS. Developmental Dynamics 235:2868 -2880, 2006.

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Finger or toe: the molecular basis of limb identity

Cited by 75 publications

References 63 publications

MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains

MDGA1, an IgSF molecule containing a MAM domain, heterophilically associates with axon- and muscle-associated binding partners through distinct structural domains

Anteroposterior patterning in the limb and digit specification: Contribution of mouse genetics

Microarray analysis of Tbx5‐induced genes expressed in the developing heart

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