2019
DOI: 10.1101/703629
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Finite Element and deformation analyses predict pattern of bone failure in loaded zebrafish spines

Abstract: The spine is the central skeletal support structure in vertebrates consisting of repeated units of bone, the vertebrae, separated by intervertebral discs that enable the movement of the spine. Spinal pathologies such as idiopathic back pain, vertebral compression fractures and intervertebral disc failure affect millions of people world-wide. Animal models can help us to understand the disease process, and zebrafish are increasingly used as they are highly genetically tractable, their spines are axially loaded … Show more

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