Fire needle therapy for moderate-severe acne: A PRISMA systematic review and meta-analysis of randomized controlled trials

Xing, Meng; Yan, Xiaoning; Sun, Xiaoying; Wang, Shoumei; Zhou, Mei; Zhu, Bo; Kuai, Le; Liu, Liu; Luo, Ying; Li, Xin; Li, Bin

doi:10.1016/j.ctim.2019.04.009

Cited by 21 publications

(14 citation statements)

References 5 publications

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“…Nutrition could be strengthened to stimulate the activity of tyrosinase, thus facilitating the formation of melanin [ 6 ]. However, acupuncture needling into the skin produces localized inflammatory stimulation that might activate amelanotic melanocytes (AMMC) in the hair root sheath outside the hair follicle, thereby promoting the differentiation of AMMCs to normal melanocytes [ 61 ]. The efficacy of fire needle therapy for vitiligo involves the immunomodulatory mechanism that is associated with regulating the proportion of Th17 cells, IL-17, and IL-23 cytokine levels, as well as the function of T lymphocytes [ 62 , 63 ].…”

Section: Discussionmentioning

confidence: 99%

A New Therapy for Vitiligo Using Fire Needles: A Systematic Review of Evidence from 3618 Subjects

Luo

Qian

Dai³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Introduction. Fire needle therapy has been reported as an effective treatment for vitiligo. However, current clinical evidence has not been systematically evaluated. The aim of this study was to determine whether fire needle therapy is effective and safe for treating vitiligo. Methods. Seven databases were searched until October 2019 for randomized controlled trials on fire needle therapy, with and without conventional treatments, versus any type of conventional therapy for treating vitiligo. The RevMan 5.3.5 software was used to perform meta-analysis of the included studies. Results. Forty-seven trials comprising 3618 patients were included. Fire needle combined with conventional vitiligo treatments had a higher efficacy (risk ratio (RR): 1.55, 95% confidence interval (CI): 1.46–1.65, P<0.00001 and RR: 1.41, 95% CI: 1.24–1.61, P<0.00001, respectively) and a greater effect on restoring the color of the area of the skin lesion (mean difference (MD): 3.40, 95% CI: 2.11–4.69, P<0.00001), increasing the pigment point of vitiligo (MD: 0.83, 95% CI: 0.54–1.13, P<0.00001) and improving the cytokine level (MD: 8.10, 95% CI: 6.94–9.27, P<0.00001) and effectual time (MD: −4.76, 95% CI: −7.33 to −2.19, P=0.0003) than traditional methods. Limb lesions (RR: 1.60, 95% CI: 1.31–1.95, P<0.00001) were more effectively treated when the treatments included fire needles, whereas the therapeutic effect of fire needles on either the head and neck (RR: 1.13, 95% CI: 0.78–1.64, P=0.52) or torso lesions (RR: 1.22, 95% CI: 0.82–1.81, P=0.33) was not significantly different compared to that without fire needles. No statistically significant differences in adverse effects (RR: 1.15, 95% CI: 0.89–1.49, P=0.28) and recurrence rates (RR: 0.90, 95% CI: 0.17–4.92, P=0.91) during the follow-up period were observed between treatment with and without fire needles. Conclusions. Fire needle therapy combined with other conventional treatments is useful in treating vitiligo. Further studies with larger sample sizes should be performed to make a conclusive judgment. This trial is registered with CRD42018094918.

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Section: Discussionmentioning

confidence: 99%

A New Therapy for Vitiligo Using Fire Needles: A Systematic Review of Evidence from 3618 Subjects

Luo

Qian

Dai³

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…A recent study has shown that it is able to reduce the release of inflammatory factors [47], promote circulation, promote metabolism, and restore damaged tissue, leading to less scarring [48]. A systematic review and meta-analysis done in 2019 indicated fire needle as a monotherapy or combined with different Chinese and Western medicines, which is equally effective as other conventional modalities of acne treatment [49]. There are no recorded side effects mentioned in the review.…”

Section: Fire Needle Therapymentioning

confidence: 99%

Progress of different treatment modalities to limit the use of antibiotics in the treatment of acne

Sanjel¹,

Zhang²

2022

Our Dermatol Online

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Acne vulgaris is one of the most common skin diseases, affecting mainly teenagers. Its treatment procedure is complex, with a long duration of medication. Antibiotics are the most preferably prescribed drugs for the treatment of acne. The long-term use of antibiotics leads to various adverse effects such as the disruption of indigenous flora and resistance. Therefore, numerous therapeutic protocols such as antimicrobial stewardship have been proposed to limit the haphazard use of oral antibiotics. This review emphasizes different topical drugs, systemic alternative drugs, laser, and light therapy, as effective therapies for acne. This review also briefly reflects the efficacy of fire needle therapy—a traditional Chinese therapy—for acne.

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“…The main objective of this work is to present an overview of XAI applications in PHM of industrial assets by using preferred reporting items for systematic reviews and metaanalyses (PRISMA, available online: www.prisma-statement.org, accessed on 4 October 2021) guidelines [43]. PRISMA is an evidence-based guideline that ensures comprehensiveness, reducing bias, increasing reliability, transparency, and clarity of the review with minimum items [44,45]. PRISMA is a 27-checklist guideline that needs to be satisfied as best as possible for the best practice in systematic review redaction.…”

Section: Review Motivationmentioning

confidence: 99%

Overview of Explainable Artificial Intelligence for Prognostic and Health Management of Industrial Assets Based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses

Nor

Pedapati

Muhammad

et al. 2021

Sensors

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Surveys on explainable artificial intelligence (XAI) are related to biology, clinical trials, fintech management, medicine, neurorobotics, and psychology, among others. Prognostics and health management (PHM) is the discipline that links the studies of failure mechanisms to system lifecycle management. There is a need, which is still absent, to produce an analytical compilation of PHM-XAI works. In this paper, we use preferred reporting items for systematic reviews and meta-analyses (PRISMA) to present a state of the art on XAI applied to PHM of industrial assets. This work provides an overview of the trend of XAI in PHM and answers the question of accuracy versus explainability, considering the extent of human involvement, explanation assessment, and uncertainty quantification in this topic. Research articles associated with the subject, since 2015 to 2021, were selected from five databases following the PRISMA methodology, several of them related to sensors. The data were extracted from selected articles and examined obtaining diverse findings that were synthesized as follows. First, while the discipline is still young, the analysis indicates a growing acceptance of XAI in PHM. Second, XAI offers dual advantages, where it is assimilated as a tool to execute PHM tasks and explain diagnostic and anomaly detection activities, implying a real need for XAI in PHM. Third, the review shows that PHM-XAI papers provide interesting results, suggesting that the PHM performance is unaffected by the XAI. Fourth, human role, evaluation metrics, and uncertainty management are areas requiring further attention by the PHM community. Adequate assessment metrics to cater to PHM needs are requested. Finally, most case studies featured in the considered articles are based on real industrial data, and some of them are related to sensors, showing that the available PHM-XAI blends solve real-world challenges, increasing the confidence in the artificial intelligence models’ adoption in the industry.

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Fire needle therapy for moderate-severe acne: A PRISMA systematic review and meta-analysis of randomized controlled trials

Cited by 21 publications

References 5 publications

A New Therapy for Vitiligo Using Fire Needles: A Systematic Review of Evidence from 3618 Subjects

A New Therapy for Vitiligo Using Fire Needles: A Systematic Review of Evidence from 3618 Subjects

Progress of different treatment modalities to limit the use of antibiotics in the treatment of acne

Overview of Explainable Artificial Intelligence for Prognostic and Health Management of Industrial Assets Based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses

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