As a result of climate change, forest fires are becoming a common factor in the dynamics of ecosystems in the forest zone of Ukraine, but the assessment of the consequences of this shift in the ecological situation is in the process of pilot studies. In the spring of 2020, a number of large ecosystem fires occurred in the Central Polissia region, which affected forests the most. Among other things, a large fire occurred in ecosystems located in the Exclusion Zone and the Zone of Unconditional (Mandatory) Resettlement, which was formed as a result of the Chornobyl accident. The ecosystems of the Chornobyl Radiological and Ecological Biosphere Reserve located within its boundaries were also affected by the fire. The consequences of this fire were assessed a year later, using mouse-like rodents as a model group. The purpose of the study was to assess and compare the communities of mouse-like rodents in areas that were affected by two degrees of fire damage—where there was a surface fire and those that were most affected (highland fire). Four polygons were created in the control-impact scheme. Each of the pairs of plots was identical in terms of typical forest vegetation conditions. Sherman traps were used for trapping. A total of 560 trap-days were processed, and 101 animals were captured. The presence of four species of rodents from the genera Apodemus, Sylvaemus, and Myodes was recorded, namely the striped field mouse, the yellow-necked wood mouse, the European wood mouse, and the bank vole. The main indicators of species diversity were calculated using information indices—species richness, evenness, and similarity. The surveys revealed both negative and positive changes in areas affected by fires. Areas characterised by relatively higher values of species diversity indices compared to the control had a high intensity of vegetation recovery. They belonged to areas with wet, relatively fertile (sugrud) and infertile (subor) forest types. The plots with low intensity of vegetation recovery had a depleted community structure and belonged to fresh and dry boreal forest. Based on this, it is possible to create a forecast of ecosystem restoration by assessing the type of forest vegetation conditions.