Firing to Wire: A Role for Activity in Establishing Layer Specificity in the Cortex: Figure 1.

Chao, Daniel L.; Wang, George J.

doi:10.1523/jneurosci.3138-07.2007

J. Neurosci.

2007

DOI: 10.1523/jneurosci.3138-07.2007

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Firing to Wire: A Role for Activity in Establishing Layer Specificity in the Cortex: Figure 1.

Daniel L. Chao¹,

George J. Wang²

Abstract: Editor's Note: These short reviews of a recent paper in the Journal, written exclusively by graduate students or postdoctoral fellows, are intended to mimic the journal clubs that exist in your own departments or institutions. For more information on the format and purpose of the Journal Club, please see http://www.jneurosci.org/misc/ifa_features.shtml.

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Activity-Dependent Callosal Axon Projections in Neonatal Mouse Cerebral Cortex

Tagawa

Hirano

2012

Neural Plasticity

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Callosal axon projections are among the major long-range axonal projections in the mammalian brain. They are formed during the prenatal and early postnatal periods in the mouse, and their development relies on both activity-independent and -dependent mechanisms. In this paper, we review recent findings about the roles of neuronal activity in callosal axon projections. In addition to the well-documented role of sensory-driven neuronal activity, recent studies using in utero electroporation demonstrated an essential role of spontaneous neuronal activity generated in neonatal cortical circuits. Both presynaptic and postsynaptic neuronal activities are critically involved in the axon development. Studies have begun to reveal intracellular signaling pathway which works downstream of neuronal activity. We also review several distinct patterns of neuronal activity observed in the developing cerebral cortex, which might play roles in activity-dependent circuit construction. Such neuronal activity during the neonatal period can be disrupted by genetic factors, such as mutations in ion channels. It has been speculated that abnormal activity caused by such factors may affect activity-dependent circuit construction, leading to some developmental disorders. We discuss a possibility that genetic mutation in ion channels may impair callosal axon projections through an activity-dependent mechanism.

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Activity-Dependent Callosal Axon Projections in Neonatal Mouse Cerebral Cortex

Tagawa

Hirano

2012

Neural Plasticity

View full text Add to dashboard Cite

show abstract

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Firing to Wire: A Role for Activity in Establishing Layer Specificity in the Cortex: Figure 1.

Cited by 1 publication

References 6 publications

Activity-Dependent Callosal Axon Projections in Neonatal Mouse Cerebral Cortex

Activity-Dependent Callosal Axon Projections in Neonatal Mouse Cerebral Cortex

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