First Antiretroviral Therapy Changes in People Living with HIV in Senegal: Incidence, Causes and Predictive Factors

Diouf, A.; Youbong, Tracie Joyner; Dieye, Fatou Lama; Cisse-Diallo, Viviane Marie Pierre; Diallo-Mbaye, Khardiata; Diop, Madoky Magatte; Maynart, Maryvonne; Diop, Cheikh Tacko; Seydi, Moussa

doi:10.4172/2155-6113.1000709

Cited by 1 publication

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References 17 publications

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“…In this study the incidence rate of initial ART regimen change was 11.36 (95% CI: 9.32-13.83) per 100 person- years follow up. This is in line with studies conducted in Thailand 13.8/100 PYs, 19 in Kenya 11.1/100PYs, 20 in Senegal 10.5/100 PYs, 21 in Gondar 10.11/100 PYs. 13 This is lower than a study conducted in Brazil 28.3/100 PYs and 1.42/ 100 person-months, 12,22 in Cameroon 14.6/100 PYs, 23 in Kenya 18.6/100 PYs, 24 in South West Ethiopia 16.08/100…”

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confidence: 91%

<p>Incidence and Predictors of Initial Antiretroviral Therapy Regimen Change Among HIV-Infected Adults Receiving Antiretroviral Therapy at Arba Minch General Hospital, Southern Ethiopia</p>

Gebremichael

Gurara

Weldehawaryat

2020

HIV

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Background: The effectiveness of the initial antiretroviral therapy regimen is the key to treatment success. However, regimen change affects this treatment success. Yet, evidence on the incidence and predictors of regimen change is scarce. Therefore, the aim of this study was to assess the incidence and predictors of initial antiretroviral therapy regimen change among HIV-infected adults receiving antiretroviral therapy. Methods: An institutional-based retrospective cohort study was conducted. Data were collected from patients' charts selected by simple random sampling. Data entered into EpiData version 4.43 and analyzed by STATA version 13. The life table was used to estimate cumulative survival. Kaplan-Meir curve and Log-rank test were used to compare the survival experience of explanatory variables. Cox proportional hazard model was used to identify predictors. Results: Five hundred and eight patients were followed for 871.87 person-years of observation with the median follow-up period of 16.12 months. The incidence rate of initial ART regimen change was 11.36 (95% CI: 9.32-13.83) per 100 person-year and the median survival time is 54 months. Not disclosing HIV status (adjusted hazard ratio (AHR) = 5.41, 95% CI = 2.38-12.27), comedication with ART (AHR = 4.64, 95% CI = 1.43-15.10), occurrence of side effect on initial regimen (AHR = 7.32, 95% CI = 4.43-12.10), baseline CD4 count <200 cells/mm3 (AHR = 2.18, 95% CI = 1.37-3.47), ambulatory/bedridden baseline functional status (AHR = 3.55, 95% CI = 2.30-5.48) were significant predictors of initial regimen change. Conclusion: The incidence rate of initial ART regimen change was found to be low. HIV disclosure status, co-medication with ART, the occurrence of side effects on an initial regimen, low baseline CD4 count, ambulatory and bedridden baseline functional status were found to be predictors.

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