First case report of Providencia Rettgeri neonatal sepsis

Abstract

BackgroundProvidencia are gram negative motile rods and is a member of the Enterobacteriaceae family. It consists of five species, namely Providencia alcalifaciens, Providencia rustigianii, Providencia stuartii, Providencia rettgeri and Providencia heimbachae. These are opportunistic pathogens and leads to infections in immunocompromised host. Providencia rettgeri has been associated with the nosocomial infections of the urinary tract and infections of wounds, burns and blood. Providencia rettgeri is very rare cause of neonatal sepsis and we report first case of neonatal late onset sepsis secondary to it.Case presentationA term male infant presented on day 4 of post-natal life with the complaint of decreased appetite, fast respiration and lethargy. The clinical examination showed features of sepsis and shock with chest radiogram showing pneumonia. The infant was started on invasive ventilation, intravenous fluids, antibiotic and inotropes. The blood culture was suggestive of multi-drug resistant P. rettgeri. The antibiotics were changed according to organism antibiotic susceptibility pattern and infant gradually improved and was discharged successfully.Conclusion Providencia rettgeri is a very rare organism to cause neonatal sepsis. The management involves early diagnosis, treatment with appropriate antibiotics and finding the source of infection.

Nitroxoline: a potent antimicrobial agent against multidrug resistant Enterobacteriaceae

“…pneumoniae , and P. rettgeri are usually isolated from specimens in the routine clinical microbiology laboratories. Most of them have been identified as opportunistic pathogens that are commonly responsible for urinary tract infection (UTI) (Sharma et al, 2017[ 19 ]; Wagenlehner et al, 2014[ 20 ]). The most causative pathogen of UTI has been reported such as E. coli and occasionally K. pneumoniae (Wagenlehner et al, 2014[ 20 ]).…”

“…K. pneumoniae also causes severe pneumonia, upper respiratory tract infection, wound infection, meningitis, and septicemia (Khan et al, 2015[ 12 ]). P. rettgeri has been partly reported as a causative pathogen of neonatal sepsis (Sharma et al, 2017[ 19 ]).…”

Screening for Bio-flocculant Producing Bacterial Strains from Asa River in Ilorin Kwara State

“…Previous reports have revealed pH tolerance of this species ranging from 4.5 to 9/10 (Claudia et al, 1999;Janda and Abbott, 2010;Igbinosa et al, 2012) with an optimum of 7.5. Likewise, an optimum pH range (6-8) for Providencia species, pH 6-9 for Raoultella ornithinolytica, pH 5-9 for Alcaligenes sp, pH 5-7.1 for Klebsiella pneumoniae and pH 5-10 for Pseudomonas sp (Bruce et al, 1981;Naqvi, 2007;Hossain et al, 2016;Lu et al, 2017;Sharma et al, 2017;Aleanizy et al, 2018) have been recorded. This study has however shown a higher tolerance of these isolates at different culture conditions but also concurrent with the reported optimum ranges.…”

Providencia rettgeri as the causal agent of the brown slime flux of Populus tomentosa

“…Providencia rettgeri was first reported by Rettger (1909) from a cholera-like epidemic in chickens and further characterized in F I G U R E 2 Neighbor-joining phylogenetic tree obtained from the analysis of the 16S rDNA nucleotide sequences from this study (MN006176 and MN006177), and sequences obtained from GenBank. The Numbers on each node are the bootstrap values for 1,000 replicates 1918 (Sharma et al, 2017;Tu, Tu, Tung, Hieu, & Romero-Jovel, 2014). The bacteria is known to interact with a variety of organisms, including loggerhead sea turtles, humans, insects (Galac & Lazzaro, 2011;Hokama et al, 2005;Mohamedova, Valcheva, Draganova, Naydenov, & Borisov, 2017;Sharma et al, 2017), nematodes (Jackson et al, 1995), frogs (Penner & Hennessy, 1979) and…”