First clinical case of VIM-1-producing Leclercia adecarboxylata: A case report and literature review

Shuhoumi, Mohammed Abdullah Al; Mhrooqi, Abdulrahman Al; Al-Rashdi, Azza; Kumar, Rajesh; Al-Jabri, Ahood; Al-Kalbani, Amal; Al-Jardani, Amina

doi:10.1016/j.medmic.2022.100075

Cited by 5 publications

(4 citation statements)

References 38 publications

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“…Another species found in the present work was Enterobacter sp. YAFL1, species of this genus have been reported as sugarcane endophytes [12], mulberry [56] and other terrestrial plants [48,51] showing the ability to promote growth [57], but also some strains have been isolated from marine sediments [58] or they may be present in fish as probiotic organisms with broad antibacterial spectrum [35]. They also have potential in the control of F. moniliforme , F. cubense , Botrytis cinerea , Ceratocystis paradoxa, Sporisorium scitamineum [12,64] and…”

Section: Discussionmentioning

confidence: 99%

Diversity of endophytic bacteria with antimicrobial potential isolated from marine macroalgae from Yacila and Cangrejos beaches, Piura-Peru

Portalatino,

Cuentas,

Angeles

et al. 2024

Preprint

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Endophytic bacteria from marine macroalgae (EBMM) have aroused interest for their antimicrobial activity, becoming a new source of bioactive compounds for the control of pathogenic bacteria, yeasts and fungi. EBMMs were isolated from Caulerpa sp., Ulva sp., Ahnfeltiopsis sp. and Chondracantus chamissoi collected from Yacila and Cangrejo beach (Piura, Peru). Antimicrobial assays against pathogenic bacteria were evaluated by the cross method, over plate test (OpT) and volatile organic compound test (VOCt). Bacteria with the best antibacterial potential were molecularly characterized, evaluated for antifungal activity and the presence of Iturin, Fengycin and Surfactin genes. Forty-six EBMM were isolated, most of them from the phylum Rhodophyta group and coming from Yacila. In the crossmatch evaluation, 10 EBMMs were found to inhibit gram-positive pathogenic bacteria (Enterococcus faecalis, Staphylococcus epidermidis, Staphylococcus aureus and Listeria monocytogenes) and 12 gram-negative bacteria (Escherichia coli and Salmonella enteric sv typhimurium). These activities were confirmed by OpT and VOCt. The selected strains were identified as 4 Bacillus sp., 2 Kluyvera ascorbata, 1 Pantoea agglomerans, 1 Leclercia adecarboxylata and 1 Enterobacter sp. The strains, P. agglomerans YAFL6, Enterobacter sp. YAFL1, Bacillus sp. YCFR6 and Bacillus sp. YUFE8 showed high antifungal activity on Candida albicans, Candida tropicalis, Colletotrichium sp., Fusarium sp., Fusarium oxysporum and Alternaria sp. In addition, K. ascorbata YAFE21 and Bacillus sp. YCFE4 showed the presence of Iturin and Fengycin genes. The results obtained show the potential of the selected marine bacteria for future applications in the production of antibacterial metabolites and antifungal control.

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Section: Discussionmentioning

confidence: 99%

Diversity of endophytic bacteria with antimicrobial potential isolated from marine macroalgae from Yacila and Cangrejos beaches, Piura-Peru

Portalatino,

Cuentas,

Angeles

et al. 2024

Preprint

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“…It is a member of the family Enterobacteriaceae, and is widely distributed in nature. The epidemiology and mechanism of L. adecarboxylata infection is poorly understood, in part because the organism can be easily misidentified as Escherichia coli in laboratories relying on conventional microbiological techniques, but there is evidence supporting translocation from the gut as one route [ 40 ]. Another opportunistic pathogen that was detected in a relatively smaller abundance in the lemon cereal bar and in the tahini with honey was Weissella confusa .…”

Section: Discussionmentioning

confidence: 99%

Microbiota and Cyanotoxin Content of Retail Spirulina Supplements and Spirulina Supplemented Foods

et al. 2023

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Cyanobacterial biomass such as spirulina (Arthrospira spp.) is widely available as a food supplement and can also be added to foods as a nutritionally beneficial ingredient. Spirulina is often produced in open ponds, which are vulnerable to contamination by various microorganisms, including some toxin-producing cyanobacteria. This study examined the microbial population of commercially available spirulina products including for the presence of cyanobacterial toxins. Five products (two supplements, three foods) were examined. The microbial populations were determined by culture methods, followed by identification of isolates using matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF), and by 16S rRNA amplicon sequencing of the products themselves and of the total growth on the enumeration plates. Toxin analysis was carried out by enzyme-linked immunosorbent assay (ELISA). Several potentially pathogenic bacteria were detected in the products, including Bacillus cereus and Klebsiella pneumoniae. Microcystin toxins were detected in all the products at levels that could lead to consumers exceeding their recommended daily limits. Substantial differences were observed in the identifications obtained using amplicon sequencing and MALDI-TOF, particularly between closely related Bacillus spp. The study showed that there are microbiological safety issues associated with commercial spirulina products that should be addressed, and these are most likely associated with the normal means of production in open ponds.

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“…predisposing risk factors such as wounds/ulcers, catheters, or immunosuppressive diseases such as cancer, renal failure, or cirrhosis [4,7,8]. The morphological and microbiological properties of L. adecarboxylata and the Escherichia genus are similar resulting in the misidentification of such infections [7,8]. After further biochemical testing with DNA hybridization, Leclercia was differentiated from other species in the Enterobacteriaceae family [6].…”

Section: Case Presentationmentioning

confidence: 99%

Leclercia adecarboxylata in a Patient With Newly Diagnosed Chronic Lymphocytic Leukemia

Balaji,

Kalra,

Ignatowicz

et al. 2024

Cureus

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Leclercia adecarboxylata is a Gram-negative bacillus commonly seen in immunocompromised individuals and often misdiagnosed as Escherichia coli. L. adecarboxylata is an opportunistic pathogen found in aquatic environments. It is a nonfatal infection that has low virulence and endorses susceptibility to many common antibiotics. We report a case of a 53-year-old immunocompromised male who was managed for L. adecarboxylata bacteremia.

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First clinical case of VIM-1-producing Leclercia adecarboxylata: A case report and literature review

Cited by 5 publications

References 38 publications

Diversity of endophytic bacteria with antimicrobial potential isolated from marine macroalgae from Yacila and Cangrejos beaches, Piura-Peru

Diversity of endophytic bacteria with antimicrobial potential isolated from marine macroalgae from Yacila and Cangrejos beaches, Piura-Peru

Microbiota and Cyanotoxin Content of Retail Spirulina Supplements and Spirulina Supplemented Foods

Leclercia adecarboxylata in a Patient With Newly Diagnosed Chronic Lymphocytic Leukemia

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