First Complete Genome Sequence of Zika Virus (
            <i>Flaviviridae</i>
            ,
            <i>Flavivirus</i>
            ) from an Autochthonous Transmission in Brazil

Cunha, Mariana Sequetin; Espósito, Danillo Lucas Alves; Rocco, Iray Maria; Maeda, Adriana Yurika; Vasami, Fernanda Gisele Silva; Nogueira, Juliana Silva; Souza, Renato Pereira de; Suzuki, Akemi; Addas‐Carvalho, Marcelo; Barjas‐Castro, Maria de Lourdes; Resende, Mariângela Ribeiro; Stucchi, Raquel Silveira Bello; Boin, I.F.S.F.; Katz, Gizelda; Angerami, Rodrigo Nogueira; Fonseca, Benedito Antônio Lopes da

doi:10.1128/genomea.00032-16

Cited by 115 publications

(99 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These disease signs were associated with ZIKV infection in the brain, neurodegeneration in the cerebellum, and infiltration of brain tissue with CD4 ϩ and CD8 ϩ T cells. One-day-old neonatal outbred Swiss mice inoculated via a subcutaneous or intracranial route with ZIKV strain SPH 2015, a Brazilian clinical isolate (49), also displayed lethargy, ataxia, and paralysis with evidence of ZIKV infection in the brain (47). Thus, ZIKV infection of neonatal mice can be used to define mechanisms of pathogenesis as an alternative to studying immunocompromised adult mice.…”

mentioning

confidence: 99%

Animal Models of Zika Virus Infection, Pathogenesis, and Immunity

Morrison

Diamond

2017

J Virol

241

239

View full text Add to dashboard Cite

Zika virus (ZIKV) is an emerging mosquito-transmitted flavivirus that now causes epidemics affecting millions of people on multiple continents. The virus has received global attention because of some of its unusual epidemiological and clinical features, including persistent infection in the male reproductive tract and sexual transmission, an ability to cross the placenta during pregnancy and infect the developing fetus to cause congenital malformations, and its association with Guillain-Barré syndrome in adults. This past year has witnessed an intensive effort by the global scientific community to understand the biology of ZIKV and to develop pathogenesis models for the rapid testing of possible countermeasures. Here, we review the recent advances in and utility and limitations of newly developed mouse and nonhuman primate models of ZIKV infection and pathogenesis.

show abstract

mentioning

confidence: 99%

Animal Models of Zika Virus Infection, Pathogenesis, and Immunity

Morrison

Diamond

2017

J Virol

241

239

View full text Add to dashboard Cite

show abstract

“…Cellular entrance, connection and fusion is induced by envelope proteins, premature fusion is averted by pre-membrane (prM), and capsid protein combines Zika nucleic acid to structure nucleocapsid. Regulation of viral replication and transcription along with stimulation of host antiviral responses is regulated by non-structural proteins [6]. A previous study based on nucleotide sequences of NS5 gene indicated three lineages of ZIKV: East African (one strain examined), Asian (one strain examined), and West African (three strains examined).…”

Section: Zikv Genomementioning

confidence: 99%

“…From Thailand to French Polynesia in 2013, this virus has spread to countries of South and Central America infecting more than one million people. Mostly infection is transient and mild but it is strongly neurotropic and cause teratogenic outcomes in fetuses [6].…”

Section: Emergence Of Zikv and Epidemic Potentialmentioning

confidence: 99%

See 1 more Smart Citation

Advances in research on Zika virus

Ali

Wahid

Rafique

et al. 2017

Asian Pacific Journal of Tropical Medicine

View full text Add to dashboard Cite

Zika virus (ZIKV) is rapidly spreading across the America and its devastating outcomes for pregnant women and infants have driven this previously ignored pathogen into the limelight. Clinical manifestations are fever, joint pain or rash and conjunctivitis. Emergence of ZIKV started with a first outbreak in the Pacific area in 2007, a second large outbreak occurred in the Pacific in 2013/2014 and subsequently the virus spread in other Pacific islands. Threat of explosive global pandemic and severe clinical complications linked with the more immediate and recurrent epidemics necessitate the development of an effective vaccine. Several vaccine platforms such as DNA vaccine, recombinant subunit vaccine, ZIKV purified inactivated vaccine, and chimeric vaccines have shown potent efficacy in vitro and in vivo trials. Moreover, number of drugs such as Sofosbuvir, BCX4450, NITD008 and 7-DMA are ready to enter phase I clinical trial because of proven anti-ZIKV activity. Monoclonal based antibodies offer promise as an intervention effective for use in pregnant women. In this review, we describe the advances in research on ZIKV such as research strategies for the development of antiviral drugs & vaccines, molecular evolution, epidemiology emergence, neurological complications and other teratogenic outcomes as well as pathogenesis.

show abstract

“…Bununla beraber Cunha ve ark. (17) transfüzyon ilişkili ilk ZİKV infeksiyonu olgusunu Brezilya'dan bildirilmiştir.…”

Section: Si̇vri̇si̇nek Dişi Bulaşunclassified