First demonstration of portable Compton camera to visualize 223-Ra concentration for radionuclide therapy

Fujieda, Kazuya; Kataoka, J.; Mochizuki, Seibu; Tagawa, Leo; Sato, Shogo; Tanaka, Ryo; Matsunaga, Keiko; Kamiya, Takashi; Watabe, Tadashi; Kato, Hirohisa; Shimosegawa, Eku; Hatazawa, Jun

doi:10.1016/j.nima.2019.162802

Cited by 16 publications

(11 citation statements)

References 5 publications

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“…Its angular resolution, measured at the FWHM, was approximately 8° at 662 keV. Since 2016, this group has been engaged in finding suitable methods to build a Compton camera for γ-ray imaging for particle therapy applications [ 122 , 123 , 124 ]. Kenichiro et al [ 125 ] also developed a Compton camera, namely a Compton–PET hybrid camera, based on Ce:GAGG detectors and demonstrated simultaneous imaging with 131 I and 18 F RI sources.…”

Section: Types Of Compton Camerasmentioning

confidence: 99%

Development and Applications of Compton Camera—A Review

Parajuli

Sakai

Parajuli³

et al. 2022

Sensors

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The history of Compton cameras began with the detection of radiation sources originally for applications in astronomy. A Compton camera is a promising γ-ray detector that operates in the wide energy range of a few tens of keV to MeV. The γ-ray detection method of a Compton camera is based on Compton scattering kinematics, which is used to determine the direction and energy of the γ-rays without using a mechanical collimator. Although the Compton camera was originally designed for astrophysical applications, it was later applied in medical imaging as well. Moreover, its application in environmental radiation measurements is also under study. Although a few review papers regarding Compton cameras have been published, they either focus very specifically on the detectors used in such cameras or the particular applications of Compton cameras. Thus, the aim of this paper is to review the features and types of Compton cameras and introduce their applications, associated imaging algorithms, improvement scopes, and their future aspects.

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Section: Types Of Compton Camerasmentioning

confidence: 99%

Development and Applications of Compton Camera—A Review

Parajuli

Sakai

Parajuli³

et al. 2022

Sensors

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“…Visualization is performed by superimposing a distribution of radioactive materials on visible light or CT images. Many fields utilize gamma-ray imaging technology, including space observation [1], medicine [2,3], and nuclear security [4]. In particular, research related to the Fukushima Daiichi Nuclear Power Station (FDNPS) accident has actively made use of gamma-ray imaging in recent years.…”

Section: Introductionmentioning

confidence: 99%

Simulation Study of a Shield-Free Directional Gamma-Ray Detector Using Small-Angle Compton Scattering

Kitayama

Terasaka

Sato

et al. 2021

Journal of Nuclear Engineering and Radiation Science

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Gamma-ray imaging is a technique for visualize the spatial distribution of radioactive materials. Gamma-ray imaging has recently been applied to research on environmental restoration and decommissioning of the Fukushima Daiichi Nuclear Power Station (FDNPS). In the present paper, we present an elemental technology study of the Gamma-ray Imager using Small-Angle Scattering (GISAS), which is intended for application at the FDNPS decommissioning site. GISAS consists of a set of directional gamma-ray detectors that do not require a shield. In this study, we investigated the feasibility of a shield-free directional gamma-ray detector by simulation. The simulation result suggests that by measuring scattered-electron energies of several keV using a scatterer detector, gamma rays with ultra-small-angle scattering could be selected. Using Compton scattering kinematics, a shield-free detector with a directivity of about 10 degree may be feasible. By arranging the directional gamma-ray detectors in an array, we expect to be able to realize the GISAS, which is small, light, and capable of quantitative measurement.

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“…Some of these characteristic X rays and nuclear gamma rays can be visualized by SPECT. Furthermore, the use of a Compton camera for the in vivo visualization of Ra, an -particle emitter used for RNT, was suggested in our previous study 23 . However, these radionuclides emit several X-rays and gamma rays with different branching ratios.…”

Section: Introductionmentioning

confidence: 99%

“…This paper proposes a “hybrid” Compton camera that realizes simultaneous wide-band imaging from a few tens of keV to approximately an MeV, combining some features of “Compton cameras” and “pinhole cameras” in a single detector system. Although the hybrid camera consists of two layers of position-sensitive detectors, similar to a Compton camera 13 , 23 , the front detector has a hole in the center. Compton and pinhole imaging are enabled using the front detector as a scatterer for high-energy photons (> 200 keV) and an active pinhole for low-energy photons (< 200 keV).…”

Section: Introductionmentioning

confidence: 99%

Performance demonstration of a hybrid Compton camera with an active pinhole for wide-band X-ray and gamma-ray imaging

Omata

Kataoka

Fujieda

et al. 2020

Sci Rep

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X-ray and gamma-ray imaging are technologies with several applications in nuclear medicine, homeland security, and high-energy astrophysics. However, it is generally difficult to realize simultaneous wide-band imaging ranging from a few tens of keV to MeV because different interactions between photons and the detector material occur, depending on the photon energies. For instance, photoabsorption occurs below 100 keV, whereas Compton scattering dominates above a few hundreds of keV. Moreover, radioactive sources generally emit both X-ray and gamma-ray photons. In this study, we develop a “hybrid” Compton camera that can simultaneously achieve X-ray and gamma-ray imaging by combining features of “Compton” and “pinhole” cameras in a single detector system. Similar to conventional Compton cameras, the detector consists of two layers of scintillator arrays with the forward layer acting as a scatterer for high-energy photons (> 200 keV) and an active pinhole for low-energy photons (< 200 keV). The experimental results on the performance of the hybrid camera were consistent with those from the Geant4 simulation. We simultaneously imaged Am (60 keV) and Cs (662 keV) in the same field of view, achieving an angular resolution of 10 (FWHM) for both sources. In addition, imaging of At was conducted for the application in future nuclear medicine, particularly radionuclide therapy. The initial demonstrative images of the At phantom were reconstructed using the pinhole mode (using 79 keV) and Compton mode (using 570 keV), exhibiting significant similarities in source-position localization. We also verified that a mouse injected with 1 MBq of At can be imaged via pinhole-mode measurement in an hour.

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First demonstration of portable Compton camera to visualize 223-Ra concentration for radionuclide therapy

Cited by 16 publications

References 5 publications

Development and Applications of Compton Camera—A Review

Development and Applications of Compton Camera—A Review

Simulation Study of a Shield-Free Directional Gamma-Ray Detector Using Small-Angle Compton Scattering

Performance demonstration of a hybrid Compton camera with an active pinhole for wide-band X-ray and gamma-ray imaging

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