First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population‐based register study

Dehlink, Eleonora; Yen, Elizabeth H.; Leichtner, Alan M.; Hait, Elizabeth J.; Fiebiger, Edda

doi:10.1111/j.1365-2222.2008.03125.x

Cited by 75 publications

(97 citation statements)

References 35 publications

(35 reference statements)

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“…Already during pregnancy, acid-suppressing medication represents a risk for maternal food allergy development, but also shi s the immune response of the o -springs towards 2 in an experimental model [73]. ese results were underlined by a population-based birth register study revealing a link between maternal acid suppression therapy during pregnancy and the development of childhood asthma [74]. In line with these data, intake of acidreducing medication during childhood was suggested to be associated with an increased pre valence of food allergy [75,76].…”

Section: Association Of Anti-ulcer Drug Intake and Allergic Reactionsmentioning

confidence: 84%

Acid suppression therapy and allergic reactions

Untersmayr¹

2015

Allergo J

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e development of pharmaceutical agents reducing gastric acidity such as sucralfate, histamine 2 (H2) receptor blockers, and proton pump inhibitors (PPIs) has been a milestone for the treatment of dyspeptic disorders. However, due to current prescription habits resulting in overuse of these potent drugs as well as over-the-counter (OTC) availability associated with self-medication, substantial health concern is related to the mechanisms of drug action as well as known side e ects in uencing gastrointestinal physiology. More than a decade ago, the rst study appeared reporting an association between anti-ulcer drug intake and food allergy development. Since then, several experimental and human studies veri ed this correlation, demonstrating that acid suppressive drugs not only in uence the sensitization capacity of orally ingested proteins, but also represent a risk factor for food allergic patients. Additionally, gastric acid suppression was reported to increase the risk for development of drug hypersensitivity reactions. ese consequences of anti-ulcer drug intake might on the one hand be associated with direct in uence of these drugs on immune responses. On the other hand reduction of gastric acidity leads to impaired gastrointestinal protein degradation. Nevertheless, also disruption of the gastrointestinal barrier function, changes in microbiome, or lack of tolerogenic peptic digests might contribute to the connection between anti-ulcer drug intake and allergic reaction. erefore, these drugs should only be prescribed based on a precise gastroenterological diagnosis taking into consideration allergological mechanisms to ensure patients' safety.Cite this as: Untersmayr E. Acid suppression therapy and allergic reactions.

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Section: Association Of Anti-ulcer Drug Intake and Allergic Reactionsmentioning

confidence: 84%

Acid suppression therapy and allergic reactions

Untersmayr¹

2015

Allergo J

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“…Meanwhile, the safety of other PPIs during pregnancy should be investigated further, as should the risks associated with use of individual PPIs during the perinatal period and potential long-term risks [220].…”

Section: Discussionmentioning

confidence: 99%

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

2011

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Proton pump inhibitors have an excellent safety profile and have become one of the most commonly prescribed class of drugs in primary and specialty care. Long-term, sometimes lifetime, use is becoming increasingly common, often without appropriate indications. This paper is a detailed review of the current evidence on this important topic, focusing on the potential adverse effects of long-term proton pump inhibitor use that have generated the greatest concern: B12 deficiency; iron deficiency; hypomagnesemia; increased susceptibility to pneumonia, enteric infections, and fractures; hypergastrinemia and cancer; drug interactions; and birth defects. We explain the pathophysiological mechanisms that may underlie each of these relationships, review the existing evidence, and discuss implications for clinical management. The benefits of proton pump inhibitor use outweigh its risks in most patients. Elderly, malnourished, immune-compromised, chronically ill, and osteoporotic patients theoretically could be at increased risk from long-term therapy.

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“…This difference does not exist in adults aged 60-83. Contraceptives in women aged 20-39 increase plasma levels of copper and ceruloplasmin, but not its absorption [2][3][4][5][6][7].…”

Section: Genetic Basis and Impact Of Age And Gender On Bioavailabilitymentioning

confidence: 99%

Essentials of Bioaccessibility and Bioavailability for Applied Nutritional Practices

Jenzer¹,

Büsser²,

Sadeghi³

2016

J Mol Biomark Diagn

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Nutrients are partially bioaccessible to be extracted from their matrix. They may be partially lost by processing to a meal and by metabolism after absorption from the GI tract. Numerous steps in this cascade have an impact on the nutrient amount which will finally be bioavailable for an effect. Daily allowances are defined and widely recommended to obtain such an effect. However, these needs are derived from observation of healthy populations and are increased to cover needs for special consumer and patient groups or for pregnancy. Daily allowances are subject to frequent changes whenever new scientific evidence arises as is the case for vitamin D. This article describes reasons why generally reasonable recommendations may fail occasionally are found among the variation of genes, age, gender, or race, as well as epigenetics, which all contribute to the individual expression of metabolic capacity and thus to differences in individual bioavailability.

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First evidence of a possible association between gastric acid suppression during pregnancy and childhood asthma: a population‐based register study

Abstract: These data provide first evidence of a significant association between in utero exposure to acid-suppressive drugs and the risk of developing childhood asthma.

Cited by 75 publications

References 35 publications

Acid suppression therapy and allergic reactions

Acid suppression therapy and allergic reactions

Adverse Effects of Long-Term Proton Pump Inhibitor Therapy

Essentials of Bioaccessibility and Bioavailability for Applied Nutritional Practices

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