First Experience in Application of New Method for Active Immunoprophylaxis of Bacillus Pynocyaneous in Patients with Open Loco-Motor System Injuries

Abstract

New effective method of active immunoprophylaxis of Bacillus Pynocyaneous in victims with open long bones fractures was elaborated. Anatoxin of Bacillus Pynocyaneous (15-30 mkg of protein/day) was injected into medullar canal of injured limb for 3-5 days after trauma. Injection of anatoxin was performed through microirrigator that was placed at the time of first osteosynthesis operation. Application of that procedure activated all components of immunity at early stages (by 7 day after injury) resulting in subsequent increase of immune response. Advantages of the given method in comparison with standard scheme of active immunoprophylaxis were confirmed by immunologic study data as well as by favorable clinical outcome of wound process.