First functional and proteomic analysis of Bothrops asper snake venom from Gorgona Island - Colombia, and its comparative characterization with two Colombian Southwest ecoregions

Jiménez-Charris, Eliécer; Montoya-Gómez, Alejandro; Torres, Jorge Kelvin; Gómez-Díaz, Mónica; Bolívar-García, Wilmar

doi:10.1016/j.biochi.2021.12.005

Cited by 3 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, the qualitative information provided by such analyses is valuable. Jiménez-Charris et al [27] characterized B. asper venom from the Gorgona island and two ecoregions from Valle del Cauca state (Pacific and western). In the venom from Gorgona island, the following protein families were identified: SVMPs, PLA 2 s, CTL, CRISP, LAAO, SVSP, PLB, NGF, and Glutaminyl cyclase (GCY).…”

Section: Proteomic Profiles Of Snake Venoms From Colombiamentioning

confidence: 99%

“…Bothrops spp. [16,27,34], Porthidium spp. [20,34], L. acrochorda [28,34], and B. myersi venoms are more hemorrhagic than B. schelegelii venom [34,37].…”

Section: Biological Activities Of Viperidae and Elapidae Venoms From ...mentioning

confidence: 99%

“…In contrast, C. d. cumanensis is only weakly hemorrhagic [34]. In addition, Viperidae snake venoms from Colombia induce hemostatic disorders related to their pro-coagulant activity demonstrated in vitro, their fibrinogenolytic activity displayed in vivo, and the alteration of coagulation times [16,19,20,27,34,36]. These venoms are characterized by a massive consumption of fibrinogen that can only be recovered by antivenom injection [9,39,43,44].…”

Section: Biological Activities Of Viperidae and Elapidae Venoms From ...mentioning

confidence: 99%

See 2 more Smart Citations

Knowledge about Snake Venoms and Toxins from Colombia: A Systematic Review

Pereañez,

Preciado,

Rey-Suárez

2023

Toxins

View full text Add to dashboard Cite

Colombia encompasses three mountain ranges that divide the country into five natural regions: Andes, Pacific, Caribbean, Amazon, and Orinoquia. These regions offer an impressive range of climates, altitudes, and landscapes, which lead to a high snake biodiversity. Of the almost 300 snake species reported in Colombia, nearly 50 are categorized as venomous. This high diversity of species contrasts with the small number of studies to characterize their venom compositions and natural history in the different ecoregions. This work reviews the available information about the venom composition, isolated toxins, and potential applications of snake species found in Colombia. Data compilation was conducted according to the PRISMA guidelines, and the systematic literature search was carried out in Pubmed/MEDLINE. Venom proteomes from nine Viperidae and three Elapidae species have been described using quantitative analytical strategies. In addition, venoms of three Colubridae species have been studied. Bioactivities reported for some of the venoms or isolated components—such as antibacterial, cytotoxicity on tumoral cell lines, and antiplasmodial properties—may be of interest to develop potential applications. Overall, this review indicates that, despite recent progress in the characterization of venoms from several Colombian snakes, it is necessary to perform further studies on the many species whose venoms remain essentially unexplored, especially those of the poorly known genus Micrurus.

show abstract

Section: Proteomic Profiles Of Snake Venoms From Colombiamentioning

confidence: 99%

“…Bothrops spp. [16,27,34], Porthidium spp. [20,34], L. acrochorda [28,34], and B. myersi venoms are more hemorrhagic than B. schelegelii venom [34,37].…”

Section: Biological Activities Of Viperidae and Elapidae Venoms From ...mentioning

confidence: 99%