First identification and quantification of lorcaserin in an herbal slimming dietary supplement

Hachem, Rabab; Malet‐Martino, Myriam; Gilard, Véronique

doi:10.1016/j.jpba.2014.05.003

Cited by 17 publications

(10 citation statements)

References 11 publications

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“…On the other hand, metformin, the prescriptional hypoglycemic drug in weight loss supplements of herbal origin, is another synthetic adulterant used usually in combination with other common adulterants: sibutramine and phenolphthalein (Lee et al, 1998). Besides them, acetazolamide, benzthiazide, bumetanide, chlorothiazide, chlorthalidone, cyclothiazide, clopamide, M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 16 ethacrynic acid, hydroflumethiazide, metolazone, probenecid, and lorcaserin could be considered as other synthetic adulterants more or less metfound to be present in herbal slimmers (Bogusz et al, 2006;Hachem et al, 2014).…”

Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Adulteration of herbal sexual enhancers and slimmers: The wish for better sexual well-being and perfect body can be risky

Skalicka-Woźniak

Georgiev

Orhan

2017

Food and Chemical Toxicology

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Section: A C C E P T E D Accepted Manuscriptmentioning

confidence: 99%

Adulteration of herbal sexual enhancers and slimmers: The wish for better sexual well-being and perfect body can be risky

Skalicka-Woźniak

Georgiev

Orhan

2017

Food and Chemical Toxicology

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“…Adulteration is an exemplary repercussion of such laxity. Well documented are instances of diuretics, stimulants, anorectics, or oxidative uncouplers contained in weight loss supplements [60][61][62][63][64][65][66][67][68][69][70][71][72][73][74], steroids in performance enhancers [75][76][77][78][79][80], and phosphodiesterase 5 inhibitors contained within male enhancement products [72,74,[81][82][83][84][85][86][87][88][89][90][91][92][93]. At least nine people died in Sweden following exposure to Kratom adulterated with Odesmethyltramadol, a potent opioid analgesic.…”

Section: Supplement Regulationmentioning

confidence: 99%

Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine

et al. 2016

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Introduction Kratom (Mitragyna speciosa), a plant native to Southeast Asia, has been used for centuries for its stimulant and opium-like effects. Mitragynine and 7-hydroxymitragynine, exclusive to M. speciosa, are the alkaloids primary responsible for Kratom's biologic and psychoactive profile, and likely contribute to its problematic use. We purchased several commercially available Kratom analogs for analysis and through our results, present evidence of probable adulteration with the highly potent and addictive plant alkaloid, 7-hydroxymitragynine. Methods A simple and sensitive LC-MS/MS method was developed for simultaneous quantification of mitragynine and 7-hydroxymitragynine in methanol extract of marketed Kratom supplements. Results We found multiple commercial Kratom products to have concentrations of 7-hydroxymitragynine that are substantially higher than those found in raw M. speciosa leaves. Conclusions We have found multiple packaged commercial Kratom products likely to contain artificially elevated concentrations of 7-hydroxymitragynine, the alkaloid responsible for M. speciosa's concerning mechanistic and side effect profile. This study describes a unique form of product adulteration, which stresses the importance of increased dietary supplement oversight of Kratom-containing supplements.

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“…[127,139,161,165] The investigation of dietary supplements adulterated with biologically active compounds, including prescription drugs, is increasingly important because of the rapid growth of the dietary supplement market [173] and the globalization of marketplaces via the Internet. Findings of adulteration have been reported from many countries.…”

Section: Discussionmentioning

confidence: 99%

“…Pai You Guo, a Chinese product that was marketed for weight loss, was found to be contaminated with sibutramine and phenolphthalein. [139] MS and NMR experiments confirmed the presence of lorcaserin. [168] Lorcaserin Lorcaserin is not a typical PEA but is a cyclized form of halogenated PEA (Fig.…”

Section: Drug Testing and Analysismentioning

confidence: 91%

Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs)

Pawar

Grundel

2016

Drug Testing and Analysis

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The multi-billion dollar dietary supplement industry is global in reach. The industry has been criticized for problems related to poor quality control, safety, misbranding, and adulteration. In this review, we describe how the US Food and Drug Administration (FDA) regulates dietary supplements within the framework of the Federal Food, Drug, and Cosmetic Act (FD&C Act). The Dietary Supplement Health and Education Act of 1994 (DSHEA), which amended the FD&C Act, gave the FDA the authority to promulgate Good Manufacturing Practices for dietary supplements and required that manufacturers provide the FDA information supporting a conclusion that the ingredients are reasonably expected to be safe if the dietary ingredients were not marketed in the USA before 15 October 1994. Recent amendments to the FD&C Act require that serious dietary-supplement-related adverse events be reported to the FDA and provide the agency with mandatory recall authority. We discuss the presence of naturally occurring (e.g. Ephedra, Citrus aurantium, Acacia) and synthetic (e.g. β-methylphenethylamines, methylsynephrine, α-ethyl-phenethylamine) biologically active phenethylamines (PEAs) in dietary supplements and of PEA drugs (e.g. clenbuterol, fenfluramine, sibutramine, lorcaserin) in weight-loss products. Regulatory actions against manufacturers of products labelled as dietary supplements that contain the aliphatic amines 1,3-dimethylamine and 1,3-dimethylbutylamine, and PEAs such as β-methylphenethylamine, aegeline, and Dendrobium illustrate the FDA's use of its authority under the FD&C Act to promote dietary supplement safety. Published 2016. This article is a U.S. Government work and is in the public domain in the USA.

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First identification and quantification of lorcaserin in an herbal slimming dietary supplement

Cited by 17 publications

References 11 publications

Adulteration of herbal sexual enhancers and slimmers: The wish for better sexual well-being and perfect body can be risky

Adulteration of herbal sexual enhancers and slimmers: The wish for better sexual well-being and perfect body can be risky

Suspected Adulteration of Commercial Kratom Products with 7-Hydroxymitragynine

Overview of regulation of dietary supplements in the USA and issues of adulteration with phenethylamines (PEAs)

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