First Initial community-acquired meningitis due to extended-spectrum beta-lactamase producing Escherichia coli complicated with multiple aortic mycotic aneurysms

Abstract

We report the first case of extended-spectrum beta-lactamase producing E. coli community-acquired meningitis complicated with multiple aortic mycotic aneurysms. Because of the acute aneurysm expansion with possible impending rupture on 2 abdominal CT scan, the patient underwent prompt vascular surgery and broad spectrum antibiotic therapy but he died of a hemorrhagic shock. Extended-spectrum beta-lactamase producing E. coli was identified from both blood and cerebrospinal fluid culture before vascular treatment. The present case report does not however change the guidelines of Gram negative bacteria meningitis in adults.

Community-acquired CTX-M-15-type ESBL-producing Escherichia coli meningitis: a case report and literature review

“…The main risk factors for CA-ABM with E. coli are alcoholism, cirrhosis, malignancies, diabetes, and immunosuppressive therapy. Nosocomial E. coli meningitis occurs frequently after neurosurgery and it is usually associated with multi-drug resistant strains [15]. Our patient had a CSF fistula secondary to a right tympanoplasty operation three years ago.…”

“…A review of the current English-language medical literature revealed a total of 8 cases of ESBLproducing E. coli meningitis, including the present case [1,[11][12][13][14][15] (Table 2). Four were nosocomial and the other three were CA-ABM cases.…”

Extended-Spectrum β-Lactamases and Their Clinical Importance in Community-Acquired Infections

“…Toplum kökenli GSBL üreten Enterobacteriaceae üyeleriyle çoğunlukla üriner sistem infeksiyonu etkeni olarak karşılaşılır. Fakat son yıllarda GSBL üreten suşlarla toplum kökenli menenjit, intraabdominal infeksiyon ve pnömoni etkeni olarak da karşılaşılmaktadır (6,7).…”

A Case of Community-Onset Bacterial Meningitis due to Extended-Spectrum Beta-Lactamase Producing Escherichia coli

“…Community-acquired meningitis due to GNB in adult patients is rare, and particularly, meningitis due to ESBL-producing GNB has been reported in only a few cases [6,7]. We also reviewed previously published reports to demonstrate the importance of ESBL-producing GNB in community-acquired meningitis.…”