First insight into the occurrence, spatial distribution, sources, and risks assessment of antibiotics in groundwater from major urban-rural settings of Pakistan

Zainab, Syeda Maria; Junaid, Muhammad; Rehman, Muhammad Yasir Abdur; Lv, Mingyang; Yue, Linxia; Xu, Nan; Malik, Riffat Naseem

doi:10.1016/j.scitotenv.2021.148298

Cited by 50 publications

(5 citation statements)

References 51 publications

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“…Other characteristics of this group include being lipophilic, having low solubility in water, and being weakly acidic. Macrolides are generally bacteriostatic; however, some of these drugs may be bactericidal at very high concentrations [ 33 , 37 ]. This group is often used to treat infections in the respiratory tract, skin, and soft tissue [ 38 ].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, other applications of this type of antibiotics are as corrosion inhibitors and in the production of polymers. The most frequent use of these antibiotics is in veterinary medicine [ 33 ].…”

Section: Resultsmentioning

confidence: 99%

“…These antibiotics cause severe environmental problems and serious damage to human health. Since conventional WWTPs are not able to fully eliminate these micropollutants, the removal efficiency of tetracyclines in treatment plants has been reported between 12 and 80% [ 33 , 43 ]. Studies have shown that approximately 25–75% or 70–90% of tetracyclines used for treating animals enter the environment through urine and feces [ 44 ].…”

Section: Resultsmentioning

confidence: 99%

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Occurrence and Distribution of Antibiotics in the Water, Sediment, and Biota of Freshwater and Marine Environments: A Review

et al. 2022

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Antibiotics, as pollutants of emerging concern, can enter marine environments, rivers, and lakes and endanger ecology and human health. The purpose of this study was to review the studies conducted on the presence of antibiotics in water, sediments, and organisms in aquatic environments (i.e., seas, rivers, and lakes). Most of the reviewed studies were conducted in 2018 (15%) and 2014 (11%). Antibiotics were reported in aqueous media at a concentration of <1 ng/L–100 μg/L. The results showed that the highest number of works were conducted in the Asian continent (seas: 74%, rivers: 78%, lakes: 87%, living organisms: 100%). The highest concentration of antibiotics in water and sea sediments, with a frequency of 49%, was related to fluoroquinolones. According to the results, the highest amounts of antibiotics in water and sediment were reported as 460 ng/L and 406 ng/g, respectively. In rivers, sulfonamides had the highest abundance (30%). Fluoroquinolones (with an abundance of 34%) had the highest concentration in lakes. Moreover, the highest concentration of fluoroquinolones in living organisms was reported at 68,000 ng/g, with a frequency of 39%. According to the obtained results, it can be concluded that sulfonamides and fluoroquinolones are among the most dangerous antibiotics due to their high concentrations in the environment. This review provides timely information regarding the presence of antibiotics in different aquatic environments, which can be helpful for estimating ecological risks, contamination levels, and their management.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Occurrence and Distribution of Antibiotics in the Water, Sediment, and Biota of Freshwater and Marine Environments: A Review

et al. 2022

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“…Trace amounts of AMs residues in pore water are reported worldwide. In a study conducted in Pakistan, the mean concentration of AMs www.nature.com/scientificreports/ was 2.3-13.8 ng L −1 , with CIP being the most frequently detected compound 46 . Research conducted in Korea confirmed the widespread presence of FQs (0.2-0.7 ng L −1 ) and SAs (0.2-0.5 ng L −1 ) in pore water, but they were present only in rural agricultural areas; however, they were not detected in non-agricultural areas 47 .…”

Section: Methods Validationmentioning

confidence: 99%

Determination of antimicrobial agents and their transformation products in an agricultural water-soil system modified with manure

Stando

Korzeniewska

Felis

et al. 2022

Sci Rep

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Manure fertilization is the primary source of veterinary antimicrobials in the water-soil system. The research gap is the fate of antimicrobials after their release into the environment. This study aimed to provide a detailed and multi-faceted examination of fertilized cultivated fields using two types of manure (poultry and bovine) enriched with selected antimicrobials. The research focused on assessing the mobility and stability of antimicrobials in the water-soil system. Additionally, transformation products of antimicrobials in the environment were identified. The extraction (solid-phase extraction and/or solid–liquid extraction) and LC–MS/MS analysis procedures were developed to determine 14 antimicrobials in the soil and pore water samples. Ten out of fourteen antimicrobials were detected in manure-amended soil and pore water samples. The highest concentration in the soil was 109.1 ng g−1 (doxycycline), while in pore water, it was 186.6 ng L−1 (ciprofloxacin). Sixteen transformation products of antimicrobials were identified in the soil and soil-related pore water. The same transformation products were detected in both soil and soil pore water extracts, with significantly higher signal intensities observed in soil extracts than in water. Transformation products were formed in oxidation, carbonylation, and ring-opening reactions.

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“…Antibiotics are one of the primary antibiotic groups that are widely used to treat various bacterial infections or inhibit pathogenic microorganisms, and they are even used as growth promoters in animal husbandry and agriculture [ 1 ]. Considering the limited removal capacity of traditional wastewater treatment plants for antibiotic pollutants [ 2 , 3 ], they have been detected in the aquatic environment such as lakes [ 4 ], rivers [ 5 , 6 ], and groundwater [ 7 ]. Antibiotics may exist for a long term in the natural environment and cause the generation of antibiotic-resistant pathogenic bacteria and antibiotic-resistant genes [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Fluidized ZnO@BCFPs Particle Electrodes for Efficient Degradation and Detoxification of Metronidazole in 3D Electro-Peroxone Process

et al. 2022

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A novel material of self-shaped ZnO-embedded biomass carbon foam pellets (ZnO@BCFPs) was successfully synthesized and used as fluidized particle electrodes in three-dimensional (3D) electro-peroxone systems for metronidazole degradation. Compared with 3D and 2D + O3 systems, the energy consumption was greatly reduced and the removal efficiencies of metronidazole were improved in the 3D + O3 system. The degradation rate constants increased from 0.0369 min−1 and 0.0337 min−1 to 0.0553 min−1, respectively. The removal efficiencies of metronidazole and total organic carbon reached 100% and 50.5% within 60 min under optimal conditions. It indicated that adding ZnO@BCFPs particle electrodes was beneficial to simultaneous adsorption and degradation of metronidazole due to improving mass transfer of metronidazole and forming numerous tiny electrolytic cells. In addition, the process of metronidazole degradation in 3D electro-peroxone systems involved hydroxyethyl cleavage, hydroxylation, nitro-reduction, N-denitrification and ring-opening. The active species of ·OH and ·O2− played an important role. Furthermore, the acute toxicity LD50 and the bioconcentration factor of intermediate products decreased with the increasing reaction time.

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First insight into the occurrence, spatial distribution, sources, and risks assessment of antibiotics in groundwater from major urban-rural settings of Pakistan

Cited by 50 publications

References 51 publications

Occurrence and Distribution of Antibiotics in the Water, Sediment, and Biota of Freshwater and Marine Environments: A Review

Occurrence and Distribution of Antibiotics in the Water, Sediment, and Biota of Freshwater and Marine Environments: A Review

Determination of antimicrobial agents and their transformation products in an agricultural water-soil system modified with manure

Fluidized ZnO@BCFPs Particle Electrodes for Efficient Degradation and Detoxification of Metronidazole in 3D Electro-Peroxone Process

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