2019
DOI: 10.3390/md17070396
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First Insight on the Mucus of the Annelid Myxicola infundibulum (Polychaeta, Sabellidae) as a Potential Prospect for Drug Discovery

Abstract: Many marine organisms, including invertebrates, produce mucosal matrices having different functions. Besides mechanical protection, the mucus of many invertebrates contains specific compounds to make the animal poisonous and/or distasteful or irritating. The presence of antibiotic molecules is more advantageous for some invertebrates to contrast bacterial attack. In the present study we investigated the mucus of the Mediterranean annelid species Myxicola infundibulum living in a gelatinous envelope made up of … Show more

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Cited by 12 publications
(15 citation statements)
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References 77 publications
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“…typhae mucus, accounting for 80% of the mucus wet weight. This finding is consistent with previous studies in many marine organisms (Connor, 1986; Davies & Hawkins, 1998; Stabili et al, 2011, 2019). The proportion of water in mucus varies by species (Davies & Hawkins, 1998; Smith & Morin, 2002; Stabili et al, 2019; Wainwright et al, 1982).…”
Section: Discussionsupporting
confidence: 93%
“…typhae mucus, accounting for 80% of the mucus wet weight. This finding is consistent with previous studies in many marine organisms (Connor, 1986; Davies & Hawkins, 1998; Stabili et al, 2011, 2019). The proportion of water in mucus varies by species (Davies & Hawkins, 1998; Smith & Morin, 2002; Stabili et al, 2019; Wainwright et al, 1982).…”
Section: Discussionsupporting
confidence: 93%
“…147 Comparative studies of secretions produced by other annelids will shed light on the underlying molecular basis of the material properties of marine worm mucus. 148 Questions currently being addressed in these studies include: How do structures of varying mucuses fluctuate to change properties so dramatically? And, do the structures of their mucins fundamentally differ?…”
Section: ■ Introductionmentioning
confidence: 99%
“…Active studies into these substances focus on the hierarchical nature of the mucuses, which exhibit distinct functionality dependent on the scale in question of the material. ,,,, Further investigation into the genomics of these organisms’ secretions will improve our understanding of mucin evolutionary history, providing insight as to if mucus, like bioluminescence, is a convergent phenomenon . Comparative studies of secretions produced by other annelids will shed light on the underlying molecular basis of the material properties of marine worm mucus . Questions currently being addressed in these studies include: How do structures of varying mucuses fluctuate to change properties so dramatically?…”
Section: Introductionmentioning
confidence: 99%
“…La presencia de lisozimas proporciona inmunidad innata no específica contra patógenos. Este poliqueto se mueve extremadamente lento, por ende es especialmente vulnerable a la colonización microbiana, por lo que existe una alta probabilidad de que la mucosa contenga agentes antimicrobianos (Stabili et al, 2019;Bruker-BioSpin, 2020). La secreción de mucosa está involucrada en la fertilización y en el éxito en las primeras etapas larvales, algunas especies de poliquetos, como Sabella spallanzanii (Gmelin, 1791), que tienen la característica de tener una dispersión de huevos por medio de la mucosa e incluso lo utilizan para la fertilización, siendo éste el medio para mejorar el éxito reproductivo.…”
Section: Microbioma Mucoso En Pielunclassified
“…El poliqueto Laeonereis acuta (Treadwell, 1923) secreta una mucosa que estabiliza la estructura del tubo, elimina las bacterias, y lo protege de cambios ambientales (contaminantes y especies reactivas de oxígeno ROS), esta mucosidad podría tener una defensa antioxidante por el contenido de carbohidratos de sus mucoproteínas (actúa como eliminador de radicales) (Stabili et al, 2019).…”
Section: Microbioma Mucoso En Pielunclassified