First International Consensus on the Methodology of Lymphangiogenesis Quantification in Solid Human Tumors

Auwera, Ilse Van der; Cao, Yihai; Tille, Jean-Christophe; Pepper, M.; Jackson, David G.; Fox, Stephen B.; Harris, Adrian L.; Dirix, L.; Vermeulen, Peter

doi:10.1002/chin.200725276

Cited by 7 publications

(11 citation statements)

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“…Much still remains to be learned about the therapeutic role for pro-and anti-lymphangiogenic therapeutics for lymphatic disease; enthusiasm for these approaches continues to grow as we acknowledge the broad array of ligands, produced in vivo by mesenchymal, immune, and tumor cells, that can stimulate the proliferation, migration, and tube formation of lymphatic endothelial cells. 37 These focused mechanistic approaches to the study of lymphedema and other lymphatic diseases continue to be vital, as we attempt to expand our insights into the complex biology of lymphedema and its potential responsiveness to pharmacologic control and molecular intervention, prevention, and reversal.…”

Section: Rocksonmentioning

confidence: 99%

The Unique Biology of Lymphatic Edema

Rockson

2009

Lymphatic Research and Biology

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Sadly, the subject of lymphatic vascular insufficiency continues to engender relative neglect by health care professionals, which represents a source of frustration and fear among patients. A re-consideration of the unique, complex biology of lymphatic vascular disorders has the capacity both to reinvigorate interest and facilitate the implementation of the correct, existing treatment interventions for individuals affected by these disease states. While most of this complex lymphatic biology remains somewhat elusive, growing insights into the molecular mechanisms of lymphatic development and repair have been instructive. Present and future considerations in lymphedema diagnosis and management must acknowledge the unique tissue biology of this disorder. Many changes are unique to the lymphatic mechanisms of chronic edema. The profound stimulus to collagen deposition in the integument seems to be unique to chronic lymphatic edema, although this biology remains largely unexplicated. Several lines of evidence also suggest that lymphatic function has a unique and important influence upon adipose biology. Molecular investigation of murine models of human acquired lymphedema are beginning to shed light on these processes. Such focused mechanistic, approaches to the study of lymphedema and other lymphatic diseases are vital, as we attempt to expand our insights into the complex biology of lymphedema and its potential responsiveness to pharmacologic control and molecular intervention, prevention, and reversal.

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Section: Rocksonmentioning

confidence: 99%

The Unique Biology of Lymphatic Edema

Rockson

2009

Lymphatic Research and Biology

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“…The score obtained is an indicator of the relative area occupied by lymph vessels. 62 This method is considered more objective and reproducible, as it avoids one of the most subjective steps in the vessel count, which is how to decide if 2 adjacent structures should be counted as 2 independent microvessels or if they are part of the same vascular structure. 72…”

Section: The Chalkley Methodsmentioning

confidence: 99%

“…62 That paper provided a review of the most relevant aspects of the process of tumor lymph vessel quantification and provided a series of recommendations to be followed in order to achieve homogeneous results that could be compared between different studies.…”

Section: Lymphangiogenesis and Metastases In Melanomamentioning

confidence: 99%

“…The main reason why it has not been possible to include parameters related to tumor lymphangiogenesis in the routine analysis of melanoma preparations has probably been the lack of consensus in the methodology employed in the studies published to date, and it is therefore very important for future research to follow the recommendations of international experts. 62 A hypothetical issue of great relevance for future research in this area is whether serum markers can be used to measure lymphangiogenesis in patients with this neoplastic disease. For example, the serum levels of VEGF-C could be monitored.…”

Section: Future Prospectsmentioning

confidence: 99%

“…71 It is thought that the formation of these hot spots is due to local changes in oxygen levels (hypoxia) that induce the focal release of prolymphangiogenic factors. 62 Hot spots are considered to be areas of biological importance, as they arise from tumor cells with a high angiogenic potential, and these cells have a greater ability to enter the blood or lymphatic circulation and thus to produce metastases via these routes. 72 Based on Weidner's description (1991), histological preparations of the tumors are first examined at low power (× 10) to identify hot spots.…”

Section: The Weidner Techniquementioning

confidence: 99%

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Lymphangiogenesis: Implications for Diagnosis, Treatment, and Prognosis in Patients With Melanoma

Pastushenko

Conejero

Carapeto

2015

Actas Dermo-Sifiliográficas (English Edition)

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Disease course in melanoma often cannot be accurately predicted by means of the prognostic factors usually considered in patients with melanoma; therefore, new factors are clearly needed. Increasingly robust scientific evidence shows that tumor lymph vessels play a key role in melanoma that metastasizes by lymphatic and hematogenous pathways. We review current knowledge and examine the implications of lymphangiogenesis in the diagnosis, treatment, and prognosis of patients with melanoma.

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Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma

Miyahara

Tanuma

Sugihara

et al. 2007

Cancer

115

114

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BACKGROUND. Lymphatic vessel density (LVD) and microvessel density (MVD) are important parameters for assessing the malignant potential of tumors and patient survival. In this report, the authors defined LVD as the density of D2‐40‐positive lymphatic vessels and MVD as the density of CD105‐positive microvessels per unit area of tissue. It was reported previously that vascular endothelial growth factor C (VEGF‐C) is a major modulator of LVD and MVD. The objectives of this study were to clarify the clinical and prognostic significance of both LVD and MVD in oral squamous cell carcinoma (OSCC) and to elucidate the lymphangiogenic and angiogenic activities of VEGF‐C in cancer tissues. METHODS. In total, 110 OSCC tissue samples were evaluated for LVD, MVD, and expression of VEGF‐C using immunohistochemistry. Correlations among these parameters and clinicopathologic factors were examined. RESULTS. LVD was significantly higher in tumors that had very high expression of VEGF‐C compared with tumors that had no/weak expression of VEGF‐C. LVD correlated well with lymph node metastasis (P < .001). MVD was correlated significantly with positive lymph node metastasis (P < .001) but not with VEGF‐C expression. In contrast, high expression of VEGF‐C was correlated significantly with advanced tumor status (P = .041). Survival rates were lower in patients who had higher LVD (P < .001), higher MVD (P = .0028), and strong VEGF‐C expression (P = .048). CONCLUSIONS. Lymphangiogenesis predominantly influenced metastasis‐free survival. The current results suggested that LVD is a more useful tool than MVD and VEGF‐C for deciding on therapeutic strategies in patients with OSCC. Cancer 2007. © 2007 American Cancer Society.

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First International Consensus on the Methodology of Lymphangiogenesis Quantification in Solid Human Tumors

Abstract: Biochemistry Z 0250 First International Consensus on the Methodology of Lymphangiogenesis Quantification in Solid Human Tumors -[155 refs.]. -(VAN DER AUWERA, I.; CAO, Y.; TILLE, J. C.; PEPPER, M. S.; JACKSON, D. G.; FOX, S. B.; HARRIS, A. L.; DIRIX, L. Y.; VERMEULEN, P. B.; Br.

Cited by 7 publications

References 1 publication

The Unique Biology of Lymphatic Edema

The Unique Biology of Lymphatic Edema

Lymphangiogenesis: Implications for Diagnosis, Treatment, and Prognosis in Patients With Melanoma

Tumor lymphangiogenesis correlates with lymph node metastasis and clinicopathologic parameters in oral squamous cell carcinoma

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