First-Line Liver Resection and Salvage Liver Transplantation Are Increasing Therapeutic Strategies for Patients With Hepatocellular Carcinoma and Child A Cirrhosis

Vennarecci, Giovanni; Ettorre, Giuseppe Maria; Antonini, Mario; Santoro, Roberto; Maritti, Micaela; Tacconi, Giovanna; Spoletini, Domenico; Tessitore, Luciana; Perracchio, Letizia; Visco, G; Puoti, Claudio; Santoro, Eugenio

doi:10.1016/j.transproceed.2007.05.073

Cited by 44 publications

(46 citation statements)

References 6 publications

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“…4,5 The results from our study also showed that SLT did not increase the operative risks or postoperative complications. The technical difficulty in SLT is mainly due to adhesions between the cut surface of prior hepatectomy and the omentum and/or the intestine.…”

Section: Discussionsupporting

confidence: 64%

Salvage Liver Transplantation for Recurrent Hepatocellular Carcinoma After Liver Resection: Feasibility of the Milan Criteria and Operative Risk

Kim

Park

Kim

et al. 2008

Transplantation Proceedings

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Section: Discussionsupporting

confidence: 64%

Salvage Liver Transplantation for Recurrent Hepatocellular Carcinoma After Liver Resection: Feasibility of the Milan Criteria and Operative Risk

Kim

Park

Kim

et al. 2008

Transplantation Proceedings

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“…29 However, literature reports about SLT are conflicting. While Belghiti and Durand 28 found that both 3-year and 5-year overall survival rates in PLT and SLT recipients were similar (82% vs. 82% and 59% vs. 61%), as did Del Gaudio et al 29 and Vennarecci et al, 25 others reported an increased risk of recurrence (54% vs.18%), with a poorer 5-year overall (41% vs. 61%) as well as disease-free survival (29% vs. 58%) for SLT than for PLT. 27 Since multiple challenges including shortage of organs, waiting list time, tumor biology, stage of tumor etc.…”

Section: Liver Transplantationmentioning

confidence: 88%

“…25 The International Consensus Conference for HCC recommends that post-transplant monitoring should include 6-to 12-monthly contrast-enhanced CT or MRI imaging and a-fetoprotein measurements. 16 ESMO Clinical Practice Guidelines 26 propose response evaluation and follow-up as follows:…”

Section: Post-treatment Surveillancementioning

confidence: 99%

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Treatment Algorithms for Managing Hepatocellular Carcinoma

Saraswat

Pandey

Shetty

2014

Journal of Clinical and Experimental Hepatology

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Early diagnosis and aggressive therapy improves outcome in hepatocellular carcinoma (HCC). Several potentially curative as well as palliative treatment options are available for patients. The choice of therapy is influenced by factors such as extent of tumor and severity of underlying liver dysfunction as well as availability of resources and of expertise. A systematic, algorithmic approach would ensure optimal therapy for each patient and is likely to improve outcomes. Even after receiving therapy for HCC, patients remain at risk for recurrent HCC as well as progression of underlying cirrhosis. Proper assessment and monitoring is needed for the underlying liver disease, which may progress to liver failure and have a major impact on long-term survival. Comprehensive care for patients with cirrhosis includes interventions such as antiviral therapy for HBV and HCV, abstention from alcohol, management of fatty liver disease, endoscopic surveillance and treatment for complications of portal hypertension and, if indicated, immunization against HAV and HBV. An algorithmic approach is useful for choosing the most appropriate treatment option for the individual patient from among the various options that are available. The general consensus is that the BCLC system should be preferred for staging HCC as it is useful in predicting outcomes and planning treatment. The BCLC system classifies patients with HCC into five categories: very early, early, intermediate, advanced, and terminal. It incorporates data on tumor status (number and size of nodules, vascular invasion, extra-hepatic spread), liver function (CTP status, presence of portal hypertension) and overall health status (constitutional symptoms, cancer symptoms, performance status). Treatment allocation according to sub-class of patients is a merit of the BCLC system; a few limitations have been noted, particularly with respect to patients with BCLC stage B and C disease. The treatment algorithm as per BCLC system is summarized in this review. ( J CLIN EXP HEPATOL 2014;4:S80-S89)

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“…Whilst a meta-analysis was not performed, they found a median 5 year survival to be 67%. Interestingly, half of studies reported a mortality rate of higher than 5% and two studies reported mortality rates of greater than 10% [70,71] . A metaanalysis by Zhu et al [72] analysed 14 studies, of which 10 overlapped with Chan's systematic review.…”

Section: Bridging Therapy and Salvage Liver Transplantationmentioning

confidence: 99%

Surgical management of hepatocellular carcinoma

Pang

Lam

2014

WJH

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Hepatocellular carcinoma (HCC) is the second most common cause of death from cancer worldwide. Standard potentially curative treatments are either resection or transplantation. The aim of this paper is to provide an overview of the surgical management of HCC, as well as highlight current issues in hepatic resection and transplantation. In summary, due to the relationship between HCC and chronic liver disease, the management of HCC depends both on tumourrelated and hepatic function-related considerations. As such, HCC is currently managed largely through nonsurgical means as the criteria, in relation to the above considerations, for surgical management is still largely

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First-Line Liver Resection and Salvage Liver Transplantation Are Increasing Therapeutic Strategies for Patients With Hepatocellular Carcinoma and Child A Cirrhosis

Cited by 44 publications

References 6 publications

Salvage Liver Transplantation for Recurrent Hepatocellular Carcinoma After Liver Resection: Feasibility of the Milan Criteria and Operative Risk

Salvage Liver Transplantation for Recurrent Hepatocellular Carcinoma After Liver Resection: Feasibility of the Milan Criteria and Operative Risk

Treatment Algorithms for Managing Hepatocellular Carcinoma

Surgical management of hepatocellular carcinoma

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