The fallacy of human memory renders it impossible to fully acknowledge those who have assisted in a work without creating invidious distinctions by failing to remember someone who has helped. However, a few individuals out of the many who have contributed to this paper are listed here.Dr. David Hamby has patiently worked with me throughout the course of the research leading to this paper. His deep understanding of the subject and immense patience with inane questions has made the work progress quite efficiently. As well, his sense of humor has kept me out of trouble on more than one occasion. In addition, the tickets to sporting events have provided a great amount of comfort to a cluttered mind. Hopefully, this compliment will not sound condescending, as I consider Dr. Hamby a giant in his field.Dan Hague and Jim Miller, two very good fiends of mine, have helped out tremendously. Dan, by providing me with equipment to complete the project, helped me progress through the stages of this research quite expeditiously, Jim, by allowing me to use his workshop and providing helpful suggestions, as well as allowing me to keep him awake while others slept, helped make a great deal of this research possible.Finally, I mention my gracious, loving wife, Nikki, to whom this work (as all my work) is dedicated. By surviving many nights without me, evenings of little conversation because of mypreoccupation with other things, complaints, and tedious tasks to help me complete this paper, she has shown me a new level of patience, understanding, and compassion. To compile the help she has been to me through the written word would require volumes. Her beauty shall endure long after this paper -or its memory -ceases to exist. vii ...
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vlllABSTRACT A tissue-equivalent spherical proportional counter is used with a modified amplifier system to measure specific energy deposited from a uniform radiation field for short periods of time (-lys to seconds) in order to extrapolate to dose in sub-micron tissue volumes. The energy deposited during these time intervals is compared to biological repair processes occurring withiin the same intervals after the initial energy deposition. The signal is integrated over a variable collection time which is adjusted with a square-wave pulse. Charge fiom particle passages is collected on the anode during the period in which the integrator is triggered, and the signal decays quickly to zero after the integrator feedback switch resets; the process repeats for every "triggering" pulse. Measurements of energy deposited from x rays, "'Cs gamma rays, and electrons from a "SrPY source for various time intervals are taken. Spectral characteristics as a function of charge collection time are observed and frequency plots of specific energy and collection time-interval are presented. In addition, a threshold energy flux is selected for each radiation type at which the formation of radicals (based on current measurements) in mammalian cells equals the rate at which radicals ...