First-order derivative synchronous spectrofluorimetric determination of two antihypertensive drugs, metolazone and valsartan, in pharmaceutical and biological matrices

Zeid, Abdallah M.; Aboshabana, Rasha; Ibrahim, F.

doi:10.1016/j.saa.2021.120591

Cited by 17 publications

(4 citation statements)

References 29 publications

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“…Regarding the proposed methods, VAS has a proven native uorescence. 32,33 For SF spectra generation, Dl (l em -l ex ) of 130 nm was chosen as the best compromise between peak separation, peak integrity, and signal intensities. As a diluting solvent, 0.1 M sulfuric was chosen for the highest synchronous response for both drugs (Fig.…”

Section: Methods Optimizationmentioning

confidence: 99%

Ecological assessment and development of analytical methods for concurrent quantification of valsartan and sacubitril: whiteness comparative study based on relative scoring

Kammoun,

Afify,

Youssef

et al. 2024

RSC Adv.

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Section: Methods Optimizationmentioning

confidence: 99%

Ecological assessment and development of analytical methods for concurrent quantification of valsartan and sacubitril: whiteness comparative study based on relative scoring

Kammoun,

Afify,

Youssef

et al. 2024

RSC Adv.

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“…These methods suffer from limitations such as complexity, high cost, time-consuming sample preparation, and the use of hazardous chemicals. In order to overcome these issues, the use of spectrofluorimetry for analyzing valsartan or pitavastatin has gained attention [16][17][18][19][20]. Spectrofluorimetry is a sensitive and selective technique that has several advantages, including simplicity, speed, cost-effectiveness, and environmental friendliness [21,22].…”

Section: Introductionmentioning

confidence: 99%

Determination of valsartan and pitavastatin using synchronous spectrofluorimetry and augmented least squares chemometric models: A comparative study with greenness and blueness assessment

Almalki,

Abduljabbar,

Alzhrani

et al. 2024

Luminescence

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Hypertension and hyperlipidemia are two common conditions that require effective management to reduce the risk of cardiovascular diseases. Among the medications commonly used for the treatment of these conditions, valsartan and pitavastatin have shown significant efficacy in lowering blood pressure and cholesterol levels, respectively. In this study, synchronous spectrofluorimetry coupled to chemometric analysis tools, specifically concentration residual augmented classical least squares (CRACLS) and spectral residual augmented classical least squares (SRACLS), was employed for the determination of valsartan and pitavastatin simultaneously. The developed models exhibited excellent predictive performance with relative root mean square error of prediction (RRMSEP) of 2.253 and 2.1381 for valsartan and pitavastatin, respectively. Hence, these models were successfully applied to the analysis of synthetic samples and commercial formulations as well as plasma samples with high accuracy and precision. Besides, the greenness and blueness profiles of the determined samples were also evaluated to assess their environmental impact and analytical practicability. The results demonstrated excellent greenness and blueness scores with AGREE score of 0.7 and BAGI score of 75 posing the proposed method as reliable and sensitive approach for the determination of valsartan and pitavastatin with potential applications in pharmaceutical quality control, bioanalytical studies, and therapeutic drug monitoring.

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“…Recently, derivative synchronous spectrofluorimetry (DSFS) has shown results that are more consistent with those obtained from HPLC, GC and infrared spectroscopy [ 23 ]. Besides, DSFS has been extensively used for quantification of various mixtures like metolazone and valsartan [ 24 ], alfuzosin hydrochloride and solifenacin succinate [ 25 ], meropenem and ertapenem [ 26 ]. This method has also been used for estimating gliquidone concentration in the presence of its alkaline degradation product [ 27 ].…”

Section: Introductionmentioning

confidence: 99%

An eco-friendly first and second derivative synchronous spectrofluorimetry for quantification of florfenicol in presence of its different degradation products. Application to kinetic stability study

Ayman,

Wahba,

El-Gindy

et al. 2024

R. Soc. Open Sci.

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Two rapid, simple, sensitive and selective derivative spectrofluorimetric methods (first and second derivative synchronous spectrofluorimetric (FDSFS and SDSFS) procedures) have been developed for the analysis of florfenicol in the presence of its various degradation products. FDSFS was applied to assay the drug in the presence of its alkaline, oxidative and photolytic degradation products while SDSFS was used to quantify it in the presence of its acidic degradation product. These methods permitted quantification of florfenicol at corresponding λ Em of 288, 287, 279 and 284 nm without interferences from any of its degradation products. Full validation procedures were applied to the suggested method according to International Conference of Harmonization guidelines. Moreover, different degradation kinetic parameters were calculated such as half-life ( t 1/2 ), degradation rate constant ( K ) and activation energy ( E a ). Using the analytical eco-scale, green analytical procedure index and analytical greenness metric approach AGREE as greenness assessment tools, the proposed method was found to be environmentally friendly.

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First-order derivative synchronous spectrofluorimetric determination of two antihypertensive drugs, metolazone and valsartan, in pharmaceutical and biological matrices

Cited by 17 publications

References 29 publications

Ecological assessment and development of analytical methods for concurrent quantification of valsartan and sacubitril: whiteness comparative study based on relative scoring

Ecological assessment and development of analytical methods for concurrent quantification of valsartan and sacubitril: whiteness comparative study based on relative scoring

Determination of valsartan and pitavastatin using synchronous spectrofluorimetry and augmented least squares chemometric models: A comparative study with greenness and blueness assessment

An eco-friendly first and second derivative synchronous spectrofluorimetry for quantification of florfenicol in presence of its different degradation products. Application to kinetic stability study

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