First-pass scintigraphy with 99mTc macroaggregated albumin: a method for evaluating pulmonary arterial flow pulsatility

Abstract

First-pass scintigraphy with Tc-MAA was able to detect flow pulsatility in pulmonary arteries. These results need to be confirmed in a larger number of individuals, and, if shown to be reproducible, may increase our understanding of lung flow physiology, and of its modifications in the presence of cardiopulmonary diseases.

Influence of Pulmonary Regurgitation Inequality on Differential Perfusion of the Lungs in Tetralogy of Fallot After Repair

“…We postulated that the RF might gradually decrease to minimal or 0 at the point of peripheral arterioles where macroaggregates of albumin are deposited in PS. This postulation was further supported by the observation of flow pulsatility in the peripheral pulmonary arterioles (19). As a result, L% by FFV was closer to L% by PS.…”

“…In the present study, we used the static distribution of 99m Tc-labeled macroaggregates of albumin as standard reference of lung tissue perfusion. Future study with positron emission tomography with ECG-gating technique might provide more accurate and detailed information of pulmonary blood flow to serve as a gold standard (19,21).…”

Biological and Optical Properties of Fluorescent Nanoparticles Developed for Intravascular Imaging

“…Improved biocompatibility has been achieved using modified blood components. Radiolabeled protein macroaggregates, such as 99mTc-labeled albumin aggregates, are used clinically to assess blood flow, but are limited by poor spatial resolution (Sapienza et al, 2004). Fluorescence or radiolabeled liposomes have been used to track blood flow (Khoobehi and Peyman, 1994), but have been limited by phagocytic uptake.…”