First Presentation of Systemic Lupus Erythematosus in a 24-Year-Old Male following mRNA COVID-19 Vaccine

Raviv, Yael; Betesh-Abay, Batya; Valdman-Grinshpoun, Yuliya; Boehm-Cohen, Liora; Kassirer, Michael; Sagy, Iftach

doi:10.1155/2022/9698138

Cited by 20 publications

(20 citation statements)

References 22 publications

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“…The adverse events were negligible and there were no severe adverse events in both groups of SLE cases and healthy individuals after SARS-CoV-2 inactivated vaccine (31). This is in sharp contrast to other mentioned reports with increased side effects and flares with use of mRNA COVID-19 vaccines such as Pfizer/BioNTech (BNT162b2) (12)(13)(14)17,18,(20)(21)(22)(23)25,26), AZD1222 vaccine (15,16) and Moderna (19,24).…”

Section: Antibody Response Following Covid-19 Vaccination In Covid-19...contrasting

confidence: 60%

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Systemic lupus erythematosus following SARS-CoV-2 vaccination; a review of literature

et al. 2022

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From March 2020, the coronavirus disease 2019 (COVID-19) pandemic challenged public health and healthcare systems worldwide. Viral infection is one of the environmental factors that has been associated with the development, relapse, or exacerbation of systemic lupus erythematosus (SLE). SLE patients are at an increased risk of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) because of immune system dysfunction related to their disease as well as immunosuppression medications. So far, the most effective way to reduce SARS-CoV-2 infection-induced hospitalization and death is vaccination. On the other hand, SLE patients present distinct challenges related to the safety and effectiveness of SARS-CoV-2 vaccination. We have reviewed some reports on the onset or flare of SLE post-COVID-19 vaccination. Of note, the mRNA COVID-19 vaccines are associated with increased SLE disease activity, more frequently than the other types of COVID-19 vaccines.

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Section: Antibody Response Following Covid-19 Vaccination In Covid-19...contrasting

confidence: 60%

“…A recent report also described a 24-year-old male who presented with positive ANA, and polyarthritis with joint pains with morning stiffness without a past medical history of autoimmune diseases, ten days following the first dose of the SARS-CoV-2 Pfizer-BioNTech mRNA vaccine (25).…”

Section: Review Of Published Cases Of Sle or Sle-like Syndromes Follo...mentioning

confidence: 99%

Systemic lupus erythematosus following SARS-CoV-2 vaccination; a review of literature

et al. 2022

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“…On the basis of the assumption that multisystem manifestations, such as SLE, that are temporally linked with pathogens are brought about by such pathogens through the induction of autoimmunity, the notion of vaccine-induced autoimmune response is suggested whenever such manifestations are temporally linked with vaccines. 24,25 But the light that the results presented here has thrown on the origin of the multisystem manifestations, which appeared to be autoimmune in the absence of such results, enables us to see that neither pathogens nor vaccines are the cause of such multisystem manifestations with which they are temporally linked.…”

Section: Discussionmentioning

confidence: 70%

The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

Ola¹

2022

Preprint

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The results of the investigation of the exact nature of the mechanisms that ensure the organism's survival in the face of the pathogen's pathological effects reveal those severe pathological manifestations that are temporally linked to a pathogen, such as those which appear in COVID-19 patients, to be manifestations of different diseases which are brought about through the same pathway under the influence of different causes which include the pathogen. Since the single pathway through which all of such diseases, which have the same "immunological nature," are brought about must be blocked for the attenuation of the influence of the pathogen to bring about the remission of the disease it causes, such diseases will undergo simultaneous remission when conditions permit immune mechanisms to attenuate the causative influence of the pathogen. Therefore, when conditions do not permit immune mechanisms to attenuate the causative influence under which any of the diseases in the same "immunological spectrum" as the disease the pathogen causes is produced through the shared pathway, the manifestations of such diseases that are linked with the pathogen will persist despite treatments that reduce pathogen load. In the absence of these results, such persistence was thought to be a consequence of the pathogen’s resistance to treatment and when it occurs in the absence of the pathogen, to be a consequence of an autoimmune response to pathogen mimicry. These results throw light on the different immunological phenomena which include those that inspired variolation and vaccination, remissions that are temporally linked with infection, the multiorgan manifestations that are seen in COVID-19 as well as long COVID.

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“…Little is known about COVID-19 vaccination in patients with autoimmune skin diseases; however, cases of onset and exacerbation of cutaneous and systemic lupus erythematosus have been reported following the use of immunizers. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 This report describes a chronic cutaneous lupus erythematosus (CCLE) exacerbation thirty days after the second dose of ChAdOx1 nCoV-19 vaccine (Oxford/AstraZeneca).…”

mentioning

confidence: 99%

“… 3 The onset or exacerbation of lupus after vaccination is rare, with few cases in the literature. 1 , 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 The international VACOLUP study indicated that COVID-19 vaccine was well tolerated in patients with systemic lupus erythematosus. Among the 696 participants assessed, only 3% reported a medically confirmed SLE flare after the immunization.…”

mentioning

confidence: 99%

Exacerbation of Chronic Cutaneous Lupus Erythematosus Triggered by Vaccine Against COVID-19

Souza

Diniz

Moura

et al. 2024

Actas Dermo-Sifiliográficas

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First Presentation of Systemic Lupus Erythematosus in a 24-Year-Old Male following mRNA COVID-19 Vaccine

Cited by 20 publications

References 22 publications

Systemic lupus erythematosus following SARS-CoV-2 vaccination; a review of literature

Systemic lupus erythematosus following SARS-CoV-2 vaccination; a review of literature

The immunological nature of the pathological effects of SARS-CoV-2 and other pathogens

Exacerbation of Chronic Cutaneous Lupus Erythematosus Triggered by Vaccine Against COVID-19

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