First prospective European study for the feasibility and safety of magnetically controlled capsule endoscopy in gastric mucosal abnormalities

Szalai, M; Helle, Krisztina; Lovász, Barbara D.; Finta, Ádám; Rosztóczy, A; Oczella, L; Madácsy, László

doi:10.3748/wjg.v28.i20.2227

Cited by 7 publications

(5 citation statements)

References 23 publications

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“…This new concept may position PCE in the centre of a new paradigm for the approach of patients with digestive bleeding disorders. Moreover, the ongoing advances in the field of magnetically controlled capsule gastroscopy may in the future permit a full pan-endoscopic non-invasive examination that also includes the esophagus and the stomach, possibly dismissing also the need for EGD in selected populations, if the encouraging preliminary results, already published, become more consolidated [13][14][15][16].…”

Section: Accepted Manuscriptmentioning

confidence: 99%

Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding

Rosa,

Cúrdia Gonçalves,

Moreira

et al. 2024

Endoscopy

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Introduction: Pan-intestinal capsule endoscopy (PCE) evaluates the small-bowel and colon, non-invasively. Aim: To evaluate diagnostic accuracy and safety of PCE vs. colonoscopy as first-line examination in suspected mid-lower gastrointestinal bleeding (MLGIB). Methods: Prospective, single-centre, single-blinded cohort study. Consecutive patients with suspected MLGIB submitted to PCE followed by same-day colonoscopy. Diagnostic accuracy for potentially haemorrhagic lesions (PHL) (combined diagnosis by PCE + colonoscopy) and incidence of adverse events were assessed. Results: One-hundred patients included, mean age 66,5 [70 (18-92)] years, 65% females. PHL were diagnosed in 46% of patients, corresponding to small-bowel and/or colon angioectasias in 70%. PCE correctly identified individuals without PHL in 50%, identifying 96% (44/46) of all individuals with PHL, vs. 50% (23/46) for colonoscopy, p<0,01. PHL were detected by PCE-only in 65% (30/46), both examinations in 28% (13/46), and colonoscopy-only in 6% (3/46). PHL were diagnosed at the ileo-colonic territory in 28% of patients; in those cases, PCE established the diagnosis in 25/28 (89%) of cases, vs. conventional colonoscopy in 23/28 (82%), p=0,125. Interventional procedures were performed at colonoscopy in 13/81 patients with iron-deficiency anaemia (IDA) (16%) vs. 6/19 patients with overt bleeding (31,6%), p<0,01. No significant adverse events occurred with PCE vs. 2% with colonoscopy. Conclusions: While assessing patients with MLGIB, PCE dismisses further invasive procedures in more than half of patients. Moreover, PCE is safe and more effective than colonoscopy in identifying PHL both in the small-bowel and colon. Our results support the potential use of PCE as first-line examination in patients with suspected MLGIB.

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Section: Accepted Manuscriptmentioning

confidence: 99%

Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding

Rosa,

Cúrdia Gonçalves,

Moreira

et al. 2024

Endoscopy

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“…Several studies have been conducted using capsule endoscopy equipped with magnets and different types of magnetic controllers for examining the stomach and small bowel [ 25 , 26 ]. Especially, magnetically controlled capsule endoscopy (MCE) with a robotic controlled system showed good performances to examine both the stomach and small bowel [ 27 – 29 ]. We examined the upper GI and small bowel simultaneously for the first time with a portable 3D MACE system, and also found a good performance like a robotic controlled system.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of three-dimensional magnetically assisted capsule endoscopy for upper gastrointestinal and small bowel examination

Oh,

Lee,

Kim

et al. 2024

PLoS ONE

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Background Magnetically assisted capsule endoscopy (MACE) showed the feasibility for upper gastrointestinal examination. To further enhance the performance of conventional MACE, it is necessary to provide quality-improved and three-dimensional images. The aim of this clinical study was to determine the efficacy and safety of novel three-dimensional MACE (3D MACE) for upper gastrointestinal and small bowel examination at once. Methods This was a prospective, single-center, non-randomized, and sequential examination study (KCT0007114) at Dongguk University Ilsan Hospital. Adult patients who visited for upper endoscopy were included. The study protocol was conducted in two stages. First, upper gastrointestinal examination was performed using 3D MACE, and a continuous small bowel examination was performed by conventional method of capsule endoscopy. Two hours later, an upper endoscopy was performed for comparison with 3D MACE examination. The primary outcome was confirmation of major gastric structures (esophagogastric junction, cardia/fundus, body, angle, antrum, and pylorus). Secondary outcomes were confirmation of esophagus and duodenal bulb, accuracy for gastric lesions, completion of small bowel examination, 3D image reconstruction of gastric lesion, and safety. Results Fifty-five patients were finally enrolled. The examination time of 3D MACE was 14.84 ± 3.02 minutes and upper endoscopy was 5.22 ± 2.39 minutes. The confirmation rate of the six major gastric structures was 98.6% in 3D MACE and 100% in upper endoscopy. Gastric lesions were identified in 43 patients during 3D MACE, and 40 patients during upper endoscopy (Sensitivity 0.97). 3D reconstructed images were acquired for all lesions inspected by 3D MACE. The continuous small bowel examination by 3D MACE was completed in 94.5%. 3D MACE showed better overall satisfaction (3D MACE 9.55 ± 0.79 and upper endoscopy 7.75 ± 2.34, p<0.0001). There were no aspiration or significant adverse event or capsule retention in the 3D MACE examination. Conclusions Novel 3D MACE system is more advanced diagnostic modality than the conventional MACE. And it is possible to perform serial upper gastrointestinal and small bowel examination as a non-invasive and one-step test. It would be also served as a bridge to pan-endoscopy.

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“…The Institute of Electrical Engineering of the Chinese Academy of Sciences, Huazhong University of Science and Technology, and the Chinese University of Hong Kong, have also conducted applied research on MAT. Several companies in China have already initiated commercial application of magnetic actuation capsule endoscopes (MACEs) in the stomach [29] . Fig.…”

Section: Pneumatic or Hydraulicmentioning

confidence: 99%

Magnetic Actuation Systems and Magnetic Robots for Gastrointestinal Examination and Treatment

Sun

Liu

Wang

2023

Chin. J. Electr. Eng.

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Magnetic actuation technology (MAT) provides novel diagnostic tools for the early screening and treatment of digestive cancers, which have high morbidity and mortality rates worldwide. The application of magnetic actuation systems and magnetic robots in gastrointestinal (GI) diagnosis and treatment to provide a comprehensive reference manual for scholars in the field of MAT research are reviewed. It describes the basic principles of magnetic actuation and magnetic field safety, introduces the design, manufacturing, control, and performance parameters of magnetic actuation systems, as well as the applicability and limitations of each system for different parts of the GI tract. It analyzes the characteristics and advantages of different types and functions of magnetic robots, summarizes the challenges faced by MAT in clinical applications, and provides an outlook on the future prospects of the field.

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First prospective European study for the feasibility and safety of magnetically controlled capsule endoscopy in gastric mucosal abnormalities

Cited by 7 publications

References 23 publications

Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding

Pan-intestinal capsule endoscopy as first-line procedure in patients with suspected mid or lower gastrointestinal bleeding

Efficacy and safety of three-dimensional magnetically assisted capsule endoscopy for upper gastrointestinal and small bowel examination

Magnetic Actuation Systems and Magnetic Robots for Gastrointestinal Examination and Treatment

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