First report and characterization of peste des petits ruminants virus in Liberia, West Africa

Boussini, H.; Chitsungo, Ethel; Bodjo, Sanne Charles; Diakité, A.; Nwankpa, Nick; Elsawalhy, Ahmed; Anderson, Joseph R.; Diallo, Adama; Dundon, William G.

doi:10.1007/s11250-016-1101-y

Cited by 7 publications

(4 citation statements)

References 14 publications

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“…In summary, the results of this study indicate that the PPRV involved in the reported outbreak in Burundi is related to the PPRV lineage III circulating in the East Africa region. Transboundary movements of infected animals might be at the origin of this outbreak, as has been described in several countries both in Asia (Muthuchelvan et al, ; Shatar et al, ) and Africa (Boussini et al, ; Dundon et al, ) although not always with clear explanations (Donduashvili et al, ). The control and regulation of such animal movements will assist in the control and management of PPRV as attempts are made to eradicate the disease globally by 2030.…”

Section: Resultsmentioning

confidence: 76%

Detection and molecular characterization of Peste des Petits Ruminants virus from outbreaks in Burundi, December 2017–January 2018

Alfred

Baziki

Dundon

et al. 2019

Transbound Emerg Dis

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In December 2017, Peste des Petits Ruminants (PPR) emerged in Burundi (East Africa) and rapidly spread to five provinces (Gitega, Kirundo, Mwaro, Muramvya and Karuzi) in the country, causing severe disease and killing more than 4,000 goats in the province of Gitega alone. An initial outbreak investigation was conducted in December 2017 by the Burundi Government Veterinary Services and samples were collected for laboratory confirmation. A competitive Enzyme Linked Immuno‐Sorbent Assay (cELISA: Chinese Patent No. ZL201210278970.9) supplied by the Lanzhou Veterinary Research Institute was used to test 112 sera and results showed around 37.5% positive samples. This high level of PPR positive sera in an animal population where PPR infection and vaccination had not been previously reported indicated the exposure of the animals to PPRV. Subsequently in January 2018, the laboratory tests conducted at the African Union‐Pan African Veterinary Vaccine Centre (AU‐PANVAC) laboratories following a joint investigative mission by the African Union‐Interafrican Bureau for Animal Resources (AU‐IBAR), AU‐PANVAC and the East African Community (EAC) confirmed the presence of PPR in Burundi. Samples tested by conventional RT‐PCR indicated the presence of the PPR virus (PPRV). Confirmatory isolation of the virus was also performed. Phylogenetic analysis revealed that the virus belongs to lineage III and shows a close relationship with PPRV isolates from Kenya in 2011 and Uganda in 2012. A possible explanation for the outbreaks of PPR in Burundi between December 2017 and February 2018 is presented.

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Section: Resultsmentioning

confidence: 76%

Detection and molecular characterization of Peste des Petits Ruminants virus from outbreaks in Burundi, December 2017–January 2018

Alfred

Baziki

Dundon

et al. 2019

Transbound Emerg Dis

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“…Years after the approval of a global strategy for the control and eradication of PPRV, there are still continued reports of new PPRV cases, even in unusual hosts, worldwide (Boussini et al 2016 ; Marashi et al 2017 ; Shatar et al 2017 ). Until now, research on several areas of basic and applied virology is still lacking, particularly, with respect to the mechanisms of disease transmission, epidemiology, virus life cycle, and the role of wildlife reservoirs in disease persistence and propagation, which are not yet well defined (Baron et al 2016 , 2017 ).…”

Section: Discussionmentioning

confidence: 99%

Reverse Genetics for Peste des Petits Ruminants Virus: Current Status and Lessons to Learn from Other Non-segmented Negative-Sense RNA Viruses

et al. 2018

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Peste des petits ruminants (PPR) is a highly contagious transboundary animal disease with a severe socio-economic impact on the livestock industry, particularly in poor countries where it is endemic. Full understanding of PPR virus (PPRV) pathobiology and molecular biology is critical for effective control and eradication of the disease. To achieve these goals, establishment of stable reverse genetics systems for PPRV would play a key role. Unfortunately, this powerful technology remains less accessible and poorly documented for PPRV. In this review, we discussed the current status of PPRV reverse genetics as well as the recent innovations and advances in the reverse genetics of other non-segmented negative-sense RNA viruses that could be applicable to PPRV. These strategies may contribute to the improvement of existing techniques and/or the development of new reverse genetics systems for PPRV.

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“…The first characterization of PPRV in Liberia was reported in April 2015 following significant mortality in sheep and goats in the country [ 57 ]. The outbreaks were in the north-central part of Liberia, close to the border with Guinea.…”

Section: Liberiamentioning

confidence: 99%

Peste des petits ruminants in Africa: a review of currently available molecular epidemiological data, 2020

2020

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Small ruminants (e.g., sheep and goats) contribute considerably to the cash income and nutrition of small farmers in most countries in Africa and Asia. Their husbandry is threatened by the highly infectious transboundary viral disease peste des petits ruminants (PPR) caused by peste-des-petits-ruminants virus (PPRV). Given its social and economic impact, PPR is presently being targeted by international organizations for global eradication by 2030. Since its first description in Côte d’Ivoire in 1942, and particularly over the last 10 years, a large amount of molecular epidemiological data on the virus have been generated in Africa. This review aims to consolidate these data in order to have a clearer picture of the current PPR situation in Africa, which will, in turn, assist authorities in global eradication attempts.

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First report and characterization of peste des petits ruminants virus in Liberia, West Africa

Cited by 7 publications

References 14 publications

Detection and molecular characterization of Peste des Petits Ruminants virus from outbreaks in Burundi, December 2017–January 2018

Detection and molecular characterization of Peste des Petits Ruminants virus from outbreaks in Burundi, December 2017–January 2018

Reverse Genetics for Peste des Petits Ruminants Virus: Current Status and Lessons to Learn from Other Non-segmented Negative-Sense RNA Viruses

Peste des petits ruminants in Africa: a review of currently available molecular epidemiological data, 2020

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