First report of isolation of antibacterial ceramides from the leaves of <i>Euclinia longiflora</i> Salisb

Munvera, Aristide Mfifen; Nyemb, Jean Noël; Tamfu, Alfred Ngenge; Mafo, Marcelle Aude Fokam; Nuzhat, Shelha; Nkengfack, Augustin E.

doi:10.1177/1934578x211048628

Cited by 2 publications

(2 citation statements)

References 25 publications

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“…The spectrum also reveals signals at δH 4,59 (1H), 4,44 (1H), 4,32 (2H), 4,09 (1H) e 4,00 (2H) that are typical of a glycosidic unit. This is corroborated by the presence of a duplet at δH 5,07 (d; J=7,5 Hz, 1H) that is attributed to H-1'from a glucose unit in beta linkages (Munvera et al, 2021;Raimundo & Silva et al, 2020). (C-5'), 72,1 (C-4'), 79,1 (C-3'), 75,8 (C-8') and 103,0 (C-1') which can attributed to anomeric carbon (Ismaeel et al, 2020).…”

Section: Resultsmentioning

confidence: 74%

Green synthesis of Fe3O4@ZnO-supported Pd nanoparticles for oxidation and hydrogenation reactions in liquid systems

Souto

Razini²,

Kauffmann³

et al. 2022

RSD

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In this work Pd nanoparticles immobilized on a hybrid solid support comprised of Fe3O4 coated by a ZnO layer were synthesized by a green method which makes use of water, a biological substrate from a local plant (Rhamnidium elaeocarpum) and inexpensive Fe3+ and Zn2+ salts. 1H-NMR and 13C-NM revealed β-sitosterol as the main component of the biological substrate. The catalytic support containing Pd nanoparticles was applied in three model solid-liquid catalytic systems, namely: alcohol oxidation, nitrocompound reduction and olefin hydrogenation. For the alcohol oxidation, benzyl alcohol was used as the substrate in a solvent-free condition with high selectivity towards benzaldehyde, and a single sample of the catalyst could be recycled up to 11 times before any loss of activity could be detected. TOF (turnover frequency) as high as 13,686 h-1 for the substrate oxidation was achieved with an average yield rate of 45.4% for formation of benzaldehyde and 81.6% of average substrate conversion after 6 catalytic cycles. For the hydrogenation experiments using cyclohexene and 4-nitrophenol as model substrates, conversion as high as 96% to 4-aminophenol and cyclohexane, respectively, was achieved after 30 minutes of reaction. Furthermore, a single sample of the catalyst could be recycled for up to 17 times for the reduction of 4-nitrophenol, and 21 times in the hydrogenation of cyclohexene. Catalytic recycling for all studied reactions was straightforward after due to the superparamagnetic property of the material, and catalyst isolation after each batch could be rapidly carried out using a Nd magnet. These results suggests that a highly active and stable catalytic system based on Pd nanoparticles supported on a multifunctional solid could be fabricated using green and inexpensive biomass under operationally simple synthesis conditions.

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Section: Resultsmentioning

confidence: 74%

Green synthesis of Fe3O4@ZnO-supported Pd nanoparticles for oxidation and hydrogenation reactions in liquid systems

Souto

Razini²,

Kauffmann³

et al. 2022

RSD

View full text Add to dashboard Cite

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“…The observed higher wound contraction rate in CG -treated mice could be due to the antibacterial effects of this extract. Regarding the structural characterization of the extracts, it shows high amount of ceramide residues, which was previously shown to have antibacterial effects on Neisseria [ 46 ], ceramide extracted from Cissus incisa leaves that showed potent antibacterial effects against Acinetobacter baumannii [ 47 ], and from Euclinia longiflora plants which show antibacterial effects on Streptococcus pneumoniae , Staphylococcus aureus , Klepsiella pneumoniae , Haemophilus influenza and Escherichia coli [ 48 ].…”

Section: Discussionmentioning

confidence: 99%

Antibacterial Effects of Commiphora gileadensis Methanolic Extract on Wound Healing

et al. 2022

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Commiphora gileadensis (CG) is a small tree distributed throughout the Middle East. It was traditionally used in perfumes in countries in this area. In Saudi Arabia, it was used to treat wounds burns and as an antidote to scorpion stings. This study aimed to evaluate the antimicrobial activity and cutaneous wound healing efficiency of the CG extracts using microbiological tests, rate of wound contraction and histopathological changes. CG pants were extracted using the methanol extraction technique; then, the methanolic extract was characterized using liquid chromatography coupled with mass spectrometry (LC–MS). Afterwards, a six-millimetre (mm) excision wound was induced in 60 male Balb/c mice. Mice were classified into two classes; each class consisted of three groups of 10 mice. In the non-infected wound class, the group I was assigned as control and received normal saline. Group II received gentamicin treatment, and group III treated with CG-methanolic extract. In the Staphylococcus aureus-infected class, group IV received normal saline, and groups V and VI were treated with gentamicin and CG-methanolic extract, respectively. The colonization of infected wounds was determined using colony-forming units (CFUs), and the percentage of wound contraction was measured in all groups. Finally, the histopathologic semi-quantitative determination of wound healing was evaluated by inflammatory cell infiltration, the presence of collagen fibres and granulation tissue, and the grade of re-epithelization. Composition analysis of the methanolic extract confirmed the presence of a high amount of ceramide (69%) and, to a lesser extent, hexosylceramide (18%) and phosphatidylethanolamine (7%) of the total amount. Additionally, there was a statistically significant difference between the percentage of wound contraction in the CG-treated and control groups in both Staphylococcus aureus-infected and non-infected wounds (p < 0.01). The colonization of the infected wounds was lower in the group treated with CG than in the control group (p < 0.01). In both non-infected and infected wounds, the CG-treated group showed significant statistical differences in inflammatory cell infiltration, collagen fibres, re-epithelization and granulation tissue formation compared with the control group (p < 0.01). The CG extract possesses antibacterial and anti-inflammatory properties that induce wound healing.

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First report of isolation of antibacterial ceramides from the leaves of Euclinia longiflora Salisb

Cited by 2 publications

References 25 publications

Green synthesis of Fe3O4@ZnO-supported Pd nanoparticles for oxidation and hydrogenation reactions in liquid systems

Green synthesis of Fe3O4@ZnO-supported Pd nanoparticles for oxidation and hydrogenation reactions in liquid systems

Antibacterial Effects of Commiphora gileadensis Methanolic Extract on Wound Healing

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