First Report of KPC-2-Producing
            <i>Klebsiella pneumoniae</i>
            Strains in Brazil

Monteiro, Jussimara; Santos, Anderson Fernandes; Asensi, Marise Dutra; Peirano, Gisele; Gales, Ana Cristina

doi:10.1128/aac.00736-08

Cited by 153 publications

(131 citation statements)

References 6 publications

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“…These data indicate the intra-bacterial transference of bla KPC-2 at this hospital. According to the literature, bla KPC is encoded by transposon Tn4401, found in a variety of transferable plasmids (2) (15) . In this study, PCR experiments using plasmid DNA confi rmed that bla KPC-2 was present in the plasmids.…”

Section: Conflict Of Interestmentioning

confidence: 99%

“…Until 2005, the geographical distribution of these enzymes in members of the family Enterobacteriaceae -K. pneumoniae, in particular -was limited to the eastern part of the United States. In Brazil, KPC has been described since 2006, and it was fi rst reported in K. pneumoniae isolates from Recife (2) , followed by reports (3) in other species from the Enterobacteriaceae and non-fermenting bacilli (4) (5) (6) . Carbapenem resistance in Proteus mirabilis caused by KPC-2 was also fi rst reported in the United States (7) in 2008, and currently, there are a few reports of P. mirabilis KPC producers worldwide (8) (9) .…”

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confidence: 99%

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Detection of bla KPC-2 in Proteus mirabilis in Brazil

Cabral

Maciel

Barros³

et al. 2015

Rev. Soc. Bras. Med. Trop.

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Introduction:Infections caused by Klebsiella pneumoniae carbapenemase (KPC)-producing isolates pose a major worldwide public health problem today. Methods: A carbapenem-resistant Proteus mirabilis clinical isolate was investigated for plasmid profi les and the occurrence of β-lactamase genes. Results: The isolate exhibited resistance to ertapenem and imipenem and was susceptible to meropenem, polymyxin, and tigecycline. Five plasmids were identifi ed in this isolate. DNA sequencing analysis revealed the presence of bla KPC-2 and bla TEM-1 genes. An addit ional PCR using plasmid DNA confi rmed that bla KPC-2 was present in one of these plasmids. Conclusions: We report the detection of bla KPC-2 in P. mirabilis in Brazil for the fi rst time. This fi nding highlights the continuous transfer of bla KPC between bacterial genera, which presents a serious challenge to the prevention of infection by multidrug-resistant bacteria.

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Section: Conflict Of Interestmentioning

confidence: 99%

mentioning

confidence: 99%

Detection of bla KPC-2 in Proteus mirabilis in Brazil

Cabral

Maciel

Barros³

et al. 2015

Rev. Soc. Bras. Med. Trop.

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“…[28][29][30] P. aeruginosa and Acinetobacter spp. showed high resistance rates to all compounds tested except polymyxin B. Doripenem also demonstrated potent activity against wild type Acinetobacter spp.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study

Gales¹,

Azevedo²,

Cereda³

et al. 2011

Braz J Infect Dis

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In vitro activity of doripenem and comparator antimicrobial agents was evaluated against Gram-negative bacilli recently isolated from Brazilian private hospitals that were enrolled in the INVITA-A-DORI Brazilian Study. A total of 805 unique Gram-negative bacilli were collected from patients hospitalized at 18 medical centers between May/08 and March/09. Each hospital was asked to submit 50 single Gram-negative bacilli isolated from blood, lower respiratory tract or intraabdominal secretions. Bacterial identification was confirmed and antimicrobial susceptibility testing was performed using Clinical Laboratory Standards Institute (CLSI) microdilution method at a central laboratory. CLSI M100-S21 (2011) or US-FDA package insert criteria (tigecycline) was used for interpretation of the antimicrobial susceptibility results. Doripenem was as active as meropenem and more active than imipenem against E. coli and K. pneumoniae isolates. A total of 50.0% of Enterobacter spp. isolates were resistant to ceftazidime but 85.7% of them were inhibited at doripenem MICs < 1 µg/mL. Polymyxin B was the only agent to show potent activity against Acinetobacter spp. (MIC50/90, < 0.5/1 µg/mL) and P. aeruginosa (MIC50/90, 1/2 µg/mL). Although high rates of imipenem (53.1%) and meropenem (44.5%) resistance were detected among P. aeruginosa, doripenem showed MIC50 of 16 µg/mL against imipenem-resistant P. aeruginosa and inhibited a greater number of imipenem-resistant P. aeruginosa (10.5%) at MIC values of < 4 µg/mL than did meropenem (0.0%). In this study, doripenem showed similar in vitro activity to that of meropenem and retained some activity against imipenem-resistant P. aeruginosa isolated from Brazilian medical centers

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“…No Brasil, em abril de 2003, identificou-se o primeiro isolado de metalo-β-lactamase produzida por Klebsiella pneumoniae (Lincopan et al, 2005), sendo o primeiro relato de diversos isolados que apresentaram um padrão de resistência similar, mostrando, dessa forma, o surgimento de novos determinantes de resistência em hospitais brasileiros (Lincopan et al, 2006, Peirano et al, 2009, Zavazcki, et al, 2009). …”

Section: Hiperprodutor De Ampc Cromossomoal (Turner 2009) Em Relaçãounclassified

“…Sua baixa prevalência está relacionada com a sua localização, sem apresentar nenhuma associação com elementos móveis (Queenan & Bush. 2007 , Monteiro et al, 2009 Gibb et al, 2002, Gales et al, 2003.…”

Section: 32carbapenemasesunclassified

Caracterização molecular da resistência aos carbapenêmicos em enterobactérias isoladas em hospitais brasileiros

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First Report of KPC-2-Producing Klebsiella pneumoniae Strains in Brazil

Cited by 153 publications

References 6 publications

Detection of bla KPC-2 in Proteus mirabilis in Brazil

Detection of bla KPC-2 in Proteus mirabilis in Brazil

Antimicrobial activity of doripenem against Gram-negative pathogens: results from INVITA-A-DORI Brazilian study

Caracterização molecular da resistência aos carbapenêmicos em enterobactérias isoladas em hospitais brasileiros

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