First reported case of subcutaneous hyalohyphomycosis caused by <i><scp>P</scp>aecilomyces variotii</i>

Vasudevan, Biju; Hazra, Nandita; Verma, Rajesh; Srinivas, V.; Pragasam, Vijendran; Badad, Ambresh

doi:10.1111/j.1365-4632.2012.05761.x

Cited by 12 publications

(9 citation statements)

References 11 publications

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“…Case reports describe immunocompromised patients presenting with P. variotii infections affecting many different organ systems including the lower respiratory tract, bone and blood . Paecilomyces variotii pneumonia, endophthalmitis, sinusitis, peritonitis and soft tissue infections have also been reported in otherwise healthy patients . Paecilomyces lilacinus is commonly associated with ocular lens implant infections and invasive soft tissue infections, both of which have been seen in immunocompromised and immunocompetent patients .…”

Section: Literature Review and Discussionmentioning

confidence: 97%

“…2,[4][5][6][7][8][9][10][11] Paecilomyces variotii pneumonia, endophthalmitis, sinusitis, peritonitis and soft tissue infections have also been reported in otherwise healthy patients. 3,[12][13][14][15][16][17][18][19] Paecilomyces lilacinus is commonly associated with ocular lens implant infections and invasive soft tissue infections, both of which have been seen in immunocompromised and immunocompetent patients. 20 Unfortunately, symptoms of infection appear to be non-specific and may be difficult to distinguish from other fungal infections.…”

Section: Literature Review and Discussionmentioning

confidence: 99%

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Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review

Feldman

Cockerham

Buchan

et al. 2016

Mycoses

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The fungi Paecilomyces variotii is a potential pathogen in immunocompromised and immunocompetent patients. Their rare association with clinical disease results in scarce literature regarding susceptibility and treatment. Here, we discuss a case involving successful treatment of probable P. variotii pneumonia with posaconazole after treatment failure with voriconazole. The current literature related to antifungal susceptibility profiles, microbiological identification methods and clinical management of infections caused by this organism is also reviewed.

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Section: Literature Review and Discussionmentioning

confidence: 97%

Section: Literature Review and Discussionmentioning

confidence: 99%

Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review

Feldman

Cockerham

Buchan

et al. 2016

Mycoses

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show abstract

“…Otherwise, P. variotii may present with various infections including pneumonia, endophthalmitis, sinusitis, and peritonitis . However, there is only 1 reported case with subcutaneous lesions in a diabetic patient caused by P. variotii . This case is the first P. variotii skin infection in a kidney transplant patient.…”

Section: Discussionmentioning

confidence: 93%

Cutaneous ulcerations caused by Paecilomyces variotii in a renal transplant recipient

Eren

Kılıç

Atalay

et al. 2018

Transplant Infectious Dis

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Skin infections caused by Paecilomyces species have been rarely described in patients with solid organ transplantation. Cutaneous manifestations are highly variable and include erythematous macules, nodules, pustules, and vesicular and necrotic lesions. The diagnosis of these infections is generally made by examination of a skin biopsy. Management of these fungal infections is difficult due to the immunocompromised state of the patients. Moreover, antifungal therapy and immunosuppressive drug interactions should be considered during treatment management. Herein, we reported a case of cellulitis caused by Paecilomyces variotii in a 56-year-old man who had undergone a kidney transplantation. Erythematous macular and nodular lesions on the left hand and left foot appeared first; within 2 months the skin lesions became ulcerated, hemorrhagic, and progressively painful and the patient was admitted to our hospital. The diagnosis was made by skin biopsy and tissue culture. The skin lesions resolved by the sixth week of the treatment with voriconazole.

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“…2 Subcutaneous or deep mycosis constitutes a group of diseases that affects primarily the skin, resulting from the implantation of pathogenic fungi into the dermis or the subcutaneous tissue. 9 Herein, we report a case with chronic ATLL associated with subcutaneous hyalohyphomycosis. 7 Hyalohyphomycosis is a term used to designate invasive fungal infections caused by hyaline-septated hyphae in tissue.…”

Section: Introductionmentioning

confidence: 96%

An Unusual Association of Adult T-Cell Leukemia/Lymphoma With Hyalohyphomycosis

Oliveira

Salvino²,

Santos³

et al. 2016

The American Journal of Dermatopathology

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Infection by human T-cell lymphotropic virus (HTLV-1) causes deregulation of the immune system, which makes the infected individuals more susceptible to infectious diseases. Immune deregulation is even more pronounced in HTLV-1 carriers with adult T-cell leukemia/lymphoma (ATLL), which results in frequent opportunistic infections. Hyalohyphomycosis is a rare subcutaneous mycosis which is more commonly associated with immunocompromised patients. We report a case of a HTLV-1-infected man with skin tumors, inguinal lymphadenomegaly, and lymphocytosis. Histopathological examination of skin biopsies revealed a T-cell lymphoma intermingled with a granulomatous process with abscesses and hyaline-septated hyphae. The lymph node showed only a T-cell lymphoma. The patient was diagnosed with acute ATLL and hyalohyphomycosis. He was treated with itraconazole for the subcutaneous mycosis and with chemotherapy for ATLL. A few months later, despite the treatment, he died because of progression of ATLL.

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First reported case of subcutaneous hyalohyphomycosis caused by Paecilomyces variotii

Abstract: This is the first reported case of subcutaneous hyalohyphomycosis caused by P. variotii. It appears that this relatively rare fungal pathogen may be starting to assert itself as an important cause of infection in humans.

Cited by 12 publications

References 11 publications

Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review

Treatment of Paecilomyces variotii pneumonia with posaconazole: case report and literature review

Cutaneous ulcerations caused by Paecilomyces variotii in a renal transplant recipient

An Unusual Association of Adult T-Cell Leukemia/Lymphoma With Hyalohyphomycosis

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