First Self-Adjuvant Multicomponent Potential Vaccine Candidates by Tethering of Four or Eight MUC1 Antigenic Immunodominant PDTRP Units on a Calixarene Platform: Synthesis and Biological Evaluation

Geraci, Corrada; Consoli, Grazia Maria Letizia; Granata, Giuseppe; Galante, Eva; Palmigiano, Angelo; Pappalardo, Matteo; Puma, Salvatore D. Di; Spadaro, Angelo

doi:10.1021/bc400242y

Cited by 47 publications

(40 citation statements)

References 43 publications

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“…Geraci et al 30 also explored the immunotherapeutic anticancer activity of calixarene. They focused on MUC-1 protein, overexpression of which is associated with human epithelial carcinomas.…”

Section: Mechanisms Of Action Of Calixarene-based Anticancer Agentsmentioning

confidence: 99%

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Ali

Hamid

Bunnori

et al. 2015

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Research on the therapeutic applications of calixarene derivatives is an emerging area of interest. The anticancer activity of various functionalized calixarenes has been reported by several research groups. Due to their superior geometric shape, calixarenes can accommodate drug molecules by forming inclusion complexes. Controlled release of anticancer drugs by calixarenes might help in targeted chemotherapy. This review summarizes the anticancer potential of the calixarenes and their drug loading properties. The potential use of calixarenes in chemoradiotherapy is also highlighted in brief.

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Section: Mechanisms Of Action Of Calixarene-based Anticancer Agentsmentioning

confidence: 99%

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Ali

Hamid

Bunnori

et al. 2015

DDDT

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“…Spadoro and co-workers designed four-valent and eight-valent vaccines using calixarene to present the PDTRP motif from MUC1. The TLR2 agonist was introduced to the template by the ether group, and the vaccine produced antibodies against the PDTRP motif ( Figure 8 ) [ 59 ].…”

Section: Multivalency In Vaccine Designmentioning

confidence: 99%

Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification

et al. 2014

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Synthetic tumor vaccines have been proven to be promising for cancer immunotherapy. However, the limitation of the specificity and efficiency of the synthetic tumor vaccines need further improvements. To overcome these difficulties, additional tumor-associated targets need to be identified, and optimized structural designs of vaccines need to be elaborated. In this review, we summarized the main strategies pursued in the design of synthetic tumor vaccines, such as multi-component, multivalency, antigen modification and other possible ways to improve the efficiency of synthetic tumor vaccines.

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“…Similarly, Geraci et al [90] synthesized the first examples of self-adjuvant vaccine candidates/immunotherapeutic anticancer agents of type 29 based on a calix [4] arene (Scheme 14). The main focus of this study was on MUC-1 protein, overexpression of which is connected with human epithelial carcinomas.…”

Section: Lower-and Upper-rim-functionalized Calix[4]arenesmentioning

confidence: 99%

Functionalized calix[4]arenes as potential therapeutic agents

2017

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Calixarenes, composed of phenolic units linked by methylene bridges at the 2,6-positions, represent a versatile class of macrocyclic compounds in supramolecular chemistry that can host small molecules or ions in their well-defined hydrophobic cavities. In recent years, it has been recognized that this class of compounds has the potential to serve as platform for the design of biological active compounds. Therefore, the calixarenes functionalized with different pharmacophoric groups have been synthesized as target structure by many researchers and were further evaluated for their biological activities. Owing to their promising biological activities such as antiviral, antibacterial, antifungal, and anticancer, the functionalized calixarenes are recently receiving increased attention from pharmaceutical/medicinal chemistry community. In this review, we summarize and discuss the synthetic approaches and the biological potential of functionalized calixarenes, mainly focusing on the selected recent studies for a comprehensive and target-oriented information, which could help in the design and synthesis of new therapeutic agents leading to the development of clinically viable drugs based on these macrocyles. K E Y W O R D Sbiological activity, calixarenes, cone conformation, functionalization, upper/lower rim/annulus

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First Self-Adjuvant Multicomponent Potential Vaccine Candidates by Tethering of Four or Eight MUC1 Antigenic Immunodominant PDTRP Units on a Calixarene Platform: Synthesis and Biological Evaluation

Cited by 47 publications

References 43 publications

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Applications of calixarenes in cancer chemotherapy: facts and perspectives

Strategy for Designing a Synthetic Tumor Vaccine: Multi-Component, Multivalency and Antigen Modification

Functionalized calix[4]arenes as potential therapeutic agents

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