2019
DOI: 10.1038/s41598-019-42166-1
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First Trimester Circulating MicroRNA Biomarkers Predictive of Subsequent Preterm Delivery and Cervical Shortening

Abstract: Preterm birth (PTB) is the leading cause of infant death and disability worldwide. The onset of preterm uterine contractions is preceded by asymptomatic cervical remodelling and ripening, which can be seen on trans-vaginal ultrasound as cervical shortening. This study aimed to identify plasma miRNA biomarkers that predict preterm birth and/or cervical shortening. We collected serial plasma samples from pregnant women prospectively from 12 to 22 weeks gestation. The nCounter miRNA assay was used to identify dif… Show more

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Cited by 63 publications
(57 citation statements)
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“…The encoding region of this miRNA is located on chromosome 3 (3p21.31) is highly expressed in ovaries and embryos, and seems to play an important role in cell cycle regulation [43]. Moreover, very recently, Cook et al described that this miRNA, in conjunction with eight others, may serve as a new circulating biomarker of preterm birth [44], which would indicate that it is essential in the tissues analyzed. On the other hand, hsa-miR-202-3p (situated in chromosome 10, q26.3) is interesting because it has been found to play a role in the first and second trimester placenta and fetal growth in two independent studies [45,46].…”
Section: Highly Expressed Mirnas In Female Reproductive Cells/tissuesmentioning
confidence: 99%
“…The encoding region of this miRNA is located on chromosome 3 (3p21.31) is highly expressed in ovaries and embryos, and seems to play an important role in cell cycle regulation [43]. Moreover, very recently, Cook et al described that this miRNA, in conjunction with eight others, may serve as a new circulating biomarker of preterm birth [44], which would indicate that it is essential in the tissues analyzed. On the other hand, hsa-miR-202-3p (situated in chromosome 10, q26.3) is interesting because it has been found to play a role in the first and second trimester placenta and fetal growth in two independent studies [45,46].…”
Section: Highly Expressed Mirnas In Female Reproductive Cells/tissuesmentioning
confidence: 99%
“…Whole blood was processed for plasma as described by Cook et al. [18] . Isolated plasma was stored in aliquots at −80 °C until further analysis.…”
Section: Methodsmentioning
confidence: 99%
“…As such, there exists much interest in their utility as potential biomarkers for pathophysiology and disease. The diagnostic potential of miRNAs has been investigated in several pregnancy-related complications such as preeclampsia [12] , ectopic pregnancy [13] , gestational diabetes [14] , recurrent pregnancy loss [15] and preterm delivery [16] , [17] , [18] . To date there have been two main approaches used to identify potential miRNA biomarkers for SGA; the measurement of previously reported candidate miRNAs in the placenta using real-time quantitative RT-PCR (RT-qPCR) [19] or untargeted profiling of maternal circulating miRNAs using microarrays [20] .…”
Section: Introductionmentioning
confidence: 99%
“…A range of miRNAs isolated from maternal plasma were described as predictive biomarkers for pre-term birth, however, whether these miRNAs were transported by EVs was not evaluated in these studies [94][95][96][97]. Identification of miRNAs transported by EVs also revealed potential biomarkers for the prediction of pre-term birth [98].…”
Section: Pre-tterm Birthmentioning
confidence: 98%