2014
DOI: 10.1371/journal.pone.0100996
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First Trimester Exposure to Anxiolytic and Hypnotic Drugs and the Risks of Major Congenital Anomalies: A United Kingdom Population-Based Cohort Study

Abstract: BackgroundDespite their widespread use the effects of taking benzodiazepines and non-benzodiazepine hypnotics during pregnancy on the risk of major congenital anomaly (MCA) are uncertain. The objectives were to estimate absolute and relative risks of MCAs in children exposed to specific anxiolytic and hypnotic drugs taken in the first trimester of pregnancy, compared with children of mothers with depression and/or anxiety but not treated with medication and children of mothers without diagnosed mental illness … Show more

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Cited by 71 publications
(53 citation statements)
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“…We did observe a statistically increased OR for pulmonary valve stenosis for mothers who reported lorazepam use. Data from a UK cohort showed no association between maternal first trimester prescriptions for diazepam and the broad categories of any birth defect, heart defects, limb defects, or genital system defects (Ban et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…We did observe a statistically increased OR for pulmonary valve stenosis for mothers who reported lorazepam use. Data from a UK cohort showed no association between maternal first trimester prescriptions for diazepam and the broad categories of any birth defect, heart defects, limb defects, or genital system defects (Ban et al, ).…”
Section: Discussionmentioning
confidence: 99%
“…This has implications for the treatment of anxiety during pregnancy. A large nationwide prescription study did not find an increase in congenital malformations in children of women exposed to anxiolytic drugs compared to non-exposed women [42]; this knowledge should facilitate pharmacological treatment of these symptoms in a clinical setting. Several psychological interventions have been evaluated to improve maternal wellbeing during pregnancy.…”
Section: -Discussionmentioning
confidence: 85%
“…Evidence is conflicting regarding short and long term impacts of benzodiazepines on the developing infant 50515253. “Floppy baby syndrome” (including poor muscle tone, hypothermia, lethargy, and breathing and feeding difficulties) has been reported in neonates exposed to benzodiazepines in utero.…”
Section: Managing Substance Use In Pregnancymentioning
confidence: 99%