First trimester fetal size and prescribed asthma medication at 15 years of age

Turner, Steve; Devereux, Graham

doi:10.1183/13993003.01509-2017

Cited by 11 publications

(20 citation statements)

References 34 publications

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“…In that study, investigators also measured the crown-rump length in the first trimester and the biparietal diameter and femur length in the second trimester, performed spirometry (at 5, 10, and 15 years of age), and collected data about asthma medication. The results showed that first and second trimester size and FEV 1 at ages 5, 10, and 15 years were reduced for those dispensed asthma medications compared with those not dispensed asthma medications (P=.003) [66].…”

Section: Low Birth Weightmentioning

confidence: 95%

“…Finally, fetal size also has been associated with increased risk of childhood asthma [48]. Turner et al [66] showed that each reduction in the z-score for first trimester size was associated with increased odds for dispensed asthma medication at 15 years of age (OR, 1.26; 95%CI, 1.03-1.54) and self-reported use of asthma medications (OR, 1.55; 95%CI, 1.16-2.08). In that study, investigators also measured the crown-rump length in the first trimester and the biparietal diameter and femur length in the second trimester, performed spirometry (at 5, 10, and 15 years of age), and collected data about asthma medication.…”

Section: Low Birth Weightmentioning

confidence: 99%

See 1 more Smart Citation

Early Life Origins of Asthma: A Review of Potential Effectors

Bobolea¹,

Arismendi²,

Valero³

et al. 2019

J Investig Allergol Clin Immunol

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There is growing evidence that events occurring early in life, both before and after birth, are significantly associated with the risk of asthma, chronic obstructive pulmonary disease, and diminished lung function later in life. In fact, from conception to death, a series of continuous, dynamic gene-environment interactions determine 2 fundamental biological processes, namely, lung development and lung aging. Over 130 birth cohorts have been initiated in the last 30 years. Data from these cohorts have improved our understanding of the inception, progression, and persistency of asthma. In this review, we summarize the main data for the early life events proven to determine later development and persistence of asthma, such as maternal atopy and smoking, preterm birth/bronchopulmonary dysplasia, infections, nutrition, obesity, smoking, and other environmental exposures in childhood and adolescence. While some of these factors are obviously impossible to prevent or eliminate, others have been proven to have a protective role, and current research is aimed optimizing them. Available prophylactic measures are also reviewed. In the case of environmental pollution, large scale political interventions successfully managed to decrease contamination levels, leading to improved lung function and lower asthma prevalence in the respective geographical areas. Future research should focus on better understanding these complex interactions in order to develop and enhance effective preventive therapeutic measures. ResumenExiste evidencia de que eventos que ocurren en fases tempranas de la vida, tanto antes como después del nacimiento, se asocian significativamente con el aumento del riesgo futuro de asma, enfermedad pulmonar obstructiva crónica y deterioro de la función pulmonar. En efecto, desde el momento de la concepción hasta la muerte, una serie de interacciones dinámicas y continuas genético-ambientales determinan dos procesos biológicos fundamentales, el desarrollo pulmonar y el envejecimiento pulmonar. En los últimos 30 años se han comenzado más de 130 cohortes de nacimiento. Los datos de estas cohortes han mejorado nuestra comprensión del inicio, la progresión y la persistencia del asma. En esta revisión, resumimos los datos principales de los eventos de la vida temprana probados que determinan el desarrollo y la persistencia posteriores del asma, como atopia materna y tabaquismo, parto prematuro/displasia broncopulmonar, infecciones, nutrición, obesidad, tabaquismo y otras exposiciones ambientales en la infancia y la adolescencia. Si bien algunos de estos factores son obviamente imposibles de prevenir o eliminar, se ha demostrado que otros tienen un papel protector, y la investigación actual apunta a optimizarlos. También se revisan las medidas profilácticas disponibles. En el caso de la contaminación ambiental, las intervenciones políticas a gran escala lograron disminuir los niveles de contaminación, lo que mejoró la función pulmonar y disminuyó la prevalencia de asma en las respectivas áreas geográficas. Las investiga...

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Section: Low Birth Weightmentioning

confidence: 95%

Section: Low Birth Weightmentioning

confidence: 99%

Early Life Origins of Asthma: A Review of Potential Effectors

Bobolea¹,

Arismendi²,

Valero³

et al. 2019

J Investig Allergol Clin Immunol

View full text Add to dashboard Cite

show abstract

“…Children responding to the questionnaire were invited to complete an FFQ assessing dietary intake and to attend an assessment that included spirometry and SPT …”

Section: Methodsmentioning

confidence: 99%

“…Singletons born to recruited women were invited to participate at age 15. An ISAAC based questionnaire, was mailed to cohort children in the month of their 15th birthday, with a single reminder if necessary.…”

Section: Assessment Of Children At Age 15mentioning

confidence: 99%

“…Children responding to the questionnaire were invited to complete an FFQ assessing dietary intake 13 and to attend an assessment that included spirometry and SPT. 11,12,15 The North of Scotland Research Ethics Committee (13/NS/0108) approved the study, written parental consent was obtained, and children gave written assent.…”

Section: Assessment Of Children At Age 15mentioning

confidence: 99%

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Maternal vitamin D and E intakes in pregnancy and asthma to age 15 years: A cohort study

Devereux

Craig

Seaton

et al. 2018

Pediatric Pulmonology

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This study investigated whether the previously reported associations in this birth cohort between maternal vitamin D and E intakes during pregnancy and childhood wheeze/asthma outcomes at age 5 and 10 years are still evident at age 15 years. In a prospective study of 1924 children recruited in utero, maternal vitamin D and E intakes during pregnancy were assessed by food frequency questionnaire and the children completed raespiratory questionnaire at age 15 years. Treatment for asthma at age 15 was also ascertained using healthcare data. Maternal vitamin D and E intakes were also related to combined childhood asthma data collected at 1, 2, 5, 10, and 15 years of age. Symptom data were available for 747 (39%) 15‐year olds and healthcare data for 1689 (88%). There were no associations between maternal vitamin D and E intakes and childhood wheeze and asthma at age 15. Analysis of combined data collected between 1 and 15 years of age demonstrated that higher maternal vitamin D and E intakes during pregnancy were associated with a reduced likelihood of being diagnosed with asthma in the first 15 years: hazard ratio (95%CI) per quartile increase in vitamin intake of 0.87 (0.78,0.98) and 0.88 (0.78,0.98), respectively. Lower maternal vitamin D and E intakes during pregnancy are associated with increased risk of children wheezing and being diagnosed with asthma in the first 10 years but not after puberty, suggesting that post‐natal exposures predominate in the etiology of incident asthma as children transition through puberty into adulthood.

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First trimester fetal proportion volumetric measurements using a Virtual Reality approach

et al. 2021

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Objective: To establish feasibility and reproducibility of fetal proportion volumetric measurements, using three-dimensional (3D) ultrasound and a Virtual Reality (VR) system.Methods: Within a population-based prospective birth cohort, 3D ultrasound datasets of 50 fetuses in the late first trimester were collected by three ultrasonographers in a single research center. V-scope software was used for volumetric measurements of total fetus, extremities, head-trunk, head, trunk, thorax, and abdomen. All measurements were performed independently by two researchers.Intraobserver and interobserver reproducibility were analyzed using Bland and Altman methods.Results: Intraobserver and interobserver analyses of volumetric measurements of total fetus, head-trunk, head, trunk, thorax and abdomen showed intraclass correlation coefficients above 0.979, coefficients of variation below 7.51% and mean difference below 3.44%. The interobserver limits of agreement were within the ±10% range for volumetric measurements of total fetus, head-trunk, head and trunk. The interobserver limits of agreement for extremities, thorax and abdomen were −26.09% to 4.77%, −14.14% to 10.00% and −14.47% to 8.83%, respectively. Conclusion:First trimester fetal proportion volumetric measurements using 3D ultrasound and VR are feasible and reproducible, except volumetric measurements of the fetal extremities. These novel volumetric measurements may be used in future research to enable detailed studies on first trimester fetal development and growth.

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First trimester fetal size and prescribed asthma medication at 15 years of age

Cited by 11 publications

References 34 publications

Early Life Origins of Asthma: A Review of Potential Effectors

Early Life Origins of Asthma: A Review of Potential Effectors

Maternal vitamin D and E intakes in pregnancy and asthma to age 15 years: A cohort study

First trimester fetal proportion volumetric measurements using a Virtual Reality approach

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