First Trimester Mean Platelet Volume, Neutrophil to Lymphocyte Ratio, and Platelet to Lymphocyte Ratio Values Are Useful Markers for Predicting Preeclampsia

Abstract

Background: Preeclampsia complicates 2% to 8% of all pregnancies. Systemic inflammatory response (SIR) markers are widely used in the diagnosis of many inflammatory diseases and in the prediction of complicated pregnancies. This study examined the diagnostic value of SIR markers during the first trimester of pregnancy to predict preeclampsia development. Methods: This retrospective case-control study was conducted from January 2020 to May 2020. We included 94 patients diagnosed with mild preeclampsia, 107 patients diagnosed with severe preeclampsia, and 100 normotensive pregnant patients as controls. We obtained the first trimester (6 to 14 weeks) complete blood cell counts for all patients. We used a receiver operating characteristic curve to evaluate the cutoff, sensitivity, and specificity values. Results: First trimester mean platelet volume (MPV), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) values were significantly higher in patients who developed preeclampsia in later pregnancy weeks. The optimal cutoff value for MPV was 10.65 fL, with a sensitivity of 63.7% and a specificity of 65.0%. The best predictor for preeclampsia was NLR at an optimal cutoff value of 4.12, with a sensitivity of 82.1% and specificity of 62.0%. At a cutoff value of 131.8, PLR predicted preeclampsia with a sensitivity rate of 65.0% and a specificity rate of 60.2%. Conclusion:The results of this study suggest that first trimester MPV, NLR, and PLR values are clinically useful markers in the prediction of preeclampsia. The increased first trimester values of MPV, NLR, and PLR also indicate that inflammation may play a crucial role in preeclampsia pathogenesis.

Maternal and neonatal outcomes of expectantly managed pregnancies with previable preterm premature rupture of membranes

“…The NLR was calculated by dividing the neutrophil count by the lymphocyte count. The PLR was calculated by dividing the platelet count by the lymphocyte count 19,20 . We used the neonatal data from birth until discharge.…”

“…The PLR was calculated by dividing the platelet count by the lymphocyte count. 19,20 We used the neonatal data from birth until discharge. Neonatal data included the birth week, birth weight, intrauterine fetal demise, length of NICU stay, neonatal morbidity and mortality, and overall survival rate at discharge.…”

The evaluation of the antepartum and intrapartum risk factors in predicting the risk of birth asphyxia

“…Advanced maternal age was diagnosed as pregnant women being 35 years or older at the delivery time 19 . Preeclampsia was identified as maternal hypertension >140/90 mmHg without a previous history of hypertension and 300 mg/L proteinuria without a history of renal disease 20,21 . GDM was diagnosed with a 75‐g oral glucose tolerance test (OGTT) between 24–28 weeks of gestation.…”

“…19 Preeclampsia was identified as maternal hypertension >140/90 mmHg without a previous history of hypertension and 300 mg/L proteinuria without a history of renal disease. 20,21 GDM was diagnosed with a 75-g oral glucose tolerance test (OGTT) between 24-28 weeks of gestation. The threshold values for fasting, 1-h, and 2-h plasma glucose concentrations were 92 mg/dL, 180 mg/dL, and 153 mg/dL, respectively.…”

Maternal mortality cases due to COVID-19 pandemic in a tertiary referral hospital

“…Pregnancy comprises a unique immunological situation that is modulated since the immune system is affected by signals generated from the placenta. [12][13][14][15][16][17][18] Moreover, it was reported that pregnant women are predisposed to serious complications and death due to seasonal influenza epidemics compared to the general population. [19] This study aimed to report the experiences of our clinic on maternal deaths due to COVID-19.…”