Fisetin, a major component derived from mulberry (<i>Morus australis</i> Poir.) leaves, prevents vascular abnormal contraction

Tsurudome, Natsuko; Minami, Yuji; Kajiya, Katsuko

doi:10.1002/biof.1798

Cited by 9 publications

(4 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Fisetin is available naturally in various plant sources; however, it was first extracted from venetian sumach ( Rhus cotinus L.) in 1833. Fisetin is also extracted from strawberries and mulberry leaves, using methanol extraction followed by liquid-liquid extraction [ 34 , 35 ]. The extract of persimmon fruit also contains fisetin as one of its active constituents, which was extracted using a number of methods, and quantified using liquid chromatography [ 36 ].…”

Section: Physicochemical Properties and Synthesis Of Fisetinmentioning

confidence: 99%

Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

Kumar

Bhatt

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

Cancer is one of the major causes of mortality, globally. Cancerous cells invade normal cells and metastasize to distant sites with the help of the lymphatic system. There are several mechanisms involved in the development and progression of cancer. Several treatment strategies including the use of phytoconstituents have evolved and been practiced for better therapeutic outcomes against cancer. Fisetin is one such naturally derived flavone that offers numerous pharmacological benefits, i.e., antioxidant, anti-inflammatory, antiangiogenic, and anticancer properties. It inhibits the rapid growth, invasiveness, and metastasis of tumors by hindering the multiplication of cancer cells, and prompts apoptosis by avoiding cell division related to actuation of caspase-9 and caspase-8. However, its poor bioavailability associated with its extreme hydrophobicity hampers its clinical utility. The issues related to fisetin delivery can be addressed by adapting to the developmental aspects of nanomedicines, such as formulating it into lipid or polymer-based systems, including nanocochleates and liposomes. This review aims to provide in-depth information regarding fisetin as a potential candidate for anticancer therapy, its properties and various formulation strategies.

show abstract

Section: Physicochemical Properties and Synthesis Of Fisetinmentioning

confidence: 99%

Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

Kumar

Bhatt

et al. 2023

Pharmaceuticals

View full text Add to dashboard Cite

show abstract

“…Mulberry polysaccharides exerted in vitro vasodilatory activity by enhancing endothelial NO generation (Wang et al, 2019). Likewise, isolated constituents of mulberry acted directly on cardiac muscles to reduce abnormal vasculature contraction (Tsurudome et al, 2022). Consequently, the mulberry fruit administration effectively controlled the increase in blood pressure might be because of flavonols and phenolic acids.…”

Section: Discussionmentioning

confidence: 99%

Section: Histopathologymentioning

confidence: 99%

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

Maqsood

Khan

Sharif

et al. 2022

Journal of Food Biochemistry

View full text Add to dashboard Cite

The current work investigated the phytochemical profile of ultrasound‐assisted ethanolic extract of Morus nigra (M. nigra) fruit. FTIR analysis of M. nigra fruit extract revealed the presence of alcohols (O‐H), alkanes (C‐H stretch), alkenes (C=C), and alkynes (C≡C). The HPLC analysis quantified the quercetin, gallic acid, vanillic acid, chlorogenic acid, syringic acid, cinnamic acid, sinapic acid, and kaempferol. Furthermore, the cardioprotective activity of ethanolic extract of M. nigra fruit was investigated. Cholesterol supplementation (2%) in the daily diet and exposure to cigarette smoke (2 cigarettes twice a day) were to induce hypertension in rats. The experimental animals were categorized into four groups: G0 (negative control), G1 (positive control), G2 (standard drug), and G3 (M. nigra fruit). The fruit extract administration at 300 mg/kg BW/day orally for 2 months significantly (p < .001) enhanced the activities of serum and cardiac tissue antioxidants in hypertensive rats. Meanwhile, the fruit extract reduced the elevated serum lipid profile while significantly increasing the high‐density lipoproteins in G3 than G1 and G2. The increase in blood pressure, liver transaminases, and serum lactate dehydrogenase also reduced significantly in M. nigra fruit extract‐treated rats. Histopathological findings revealed mild normalization of cardiac myocytes with central nuclei, branching, and cross‐striations. Consequently, the M. nigra fruit extract exerted the cardioprotective potential via increasing the antioxidant enzymes and reducing the lipids, lactate dehydrogenase, liver transaminases, and blood pressure. The therapeutic potential of M. nigra fruit can be due to flavonols and phenolic acids. Practical applications The present work quantified the Morus nigra fruit phytochemicals and its significant role in reducing lipid markers and blood pressure and improving antioxidant status in rats fed a hypercholesterolemic diet and exposed to cigarette smoke. Conclusively, the inclusion of M. nigra fruit in daily diet could improve the cardiac health of the individuals. Furthermore, the therapeutic potential of M. nigra fruit and its isolated constituents in modulating the gene expression against cardiac problems can explore after clinical trials and standardization in higher animals.

show abstract

“…Fisetin belongs to a class of plant-derived flavonoids and is also the main component of the traditional Chinese medicine named mulberry leaves and Cotinus coggygria [7,8]. Apart from several fruits and vegetables, fisetin is abundantly present in various acacia trees and shrubs [6].…”

Section: Fisetin Structure Physicochemical Attributes Pharmacokinetic...mentioning

confidence: 99%

An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways

Tang,

Deng,

Jiang

et al. 2023

Biomedicines

View full text Add to dashboard Cite

The nervous system plays a leading role in the regulation of physiological functions and activities in the body. However, a variety of diseases related to the nervous system have a serious impact on human health. It is increasingly clear that neurological diseases are multifactorial pathological processes involving multiple cellular systems, and the onset of these diseases usually involves a diverse array of molecular mechanisms. Unfortunately, no effective therapy exists to slow down the progression or prevent the development of diseases only through the regulation of a single factor. To this end, it is pivotal to seek an ideal therapeutic approach for challenging the complicated pathological process to achieve effective treatment. In recent years, fisetin, a kind of flavonoid widely existing in fruits, vegetables and other plants, has shown numerous interesting biological activities with clinical potentials including anti-inflammatory, antioxidant and neurotrophic effects. In addition, fisetin has been reported to have diverse pharmacological properties and neuroprotective potentials against various neurological diseases. The neuroprotective effects were ascribed to its unique biological properties and multiple clinical pharmacological activities associated with the treatment of different neurological disorders. In this review, we summarize recent research progress regarding the neuroprotective potential of fisetin and the underlying signaling pathways of the treatment of several neurological diseases.

show abstract

Fisetin, a major component derived from mulberry (Morus australis Poir.) leaves, prevents vascular abnormal contraction

Cited by 9 publications

References 31 publications

Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

Fisetin in Cancer: Attributes, Developmental Aspects, and Nanotherapeutics

Phytochemical characterization ofMorus nigrafruit ultrasound‐assisted ethanolic extract for its cardioprotective potential

An Overview of Recent Advances in the Neuroprotective Potentials of Fisetin against Diverse Insults in Neurological Diseases and the Underlying Signaling Pathways

Contact Info

Product

Resources

About