Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration

Singh, Sandeep; Singh, Abhishek Kumar; Garg, Geetika; Rizvi, Syed Ibrahim

doi:10.1016/j.lfs.2017.11.004

Cited by 109 publications

(69 citation statements)

References 61 publications

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“…It was found in some vegetables and fruits such as lettuce, cucumbers, strawberry, and grapes (Sak et al, 2016). Previous studies have shown that FST has anti-tumor (Ferreira de Oliveira et al, 2018;Sun et al, 2018), anti-oxidation (Singh et al, 2018;Zhang et al, 2018), antiinflammatory Huang et al, 2018), and other pharmacological effects. It has been reported that FST inhibits inflammation related cytokines like TNF-a, IL-6, and NF-kB in streptozotocin (STZ)-induced diabetic cardiomyopathy rats (Althunibat et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy

Zhang

Zhao

et al. 2020

Front. Pharmacol.

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Acetaminophen (APAP) overdose is a leading cause of drug-induced acute liver failure in clinical and hospital settings. Fisetin (FST) is a phenolic compound derived from natural products such as fruit and vegetables. Our research investigated the protective mechanisms of FST in APAP-induced hepatic injury in vitro and vivo. Assessment of mouse serum levels of alanine/aspartate aminotransferases (ALT/AST), liver myeloperoxidase (MPO) activity, malondialdehyde (MDA), glutathione (GSH), and reactive oxygen species (ROS) demonstrated the protective effects of FST toward APAP-induced liver injury. FST also reversed an APAP-induced decrease in mouse L-02 cell line viability. Our results also showed that FST significantly promoted APAPinduced autophagy and inhibited inflammasome activation both in vivo and in vitro. We also found that silencing ATG5, using si-ATG5, reduced the protective effects of FST against APAP-induced hepatotoxicity and reversed the effects on autophagy. Finally, we used the autophagy inhibitor, 3-methyladenine (3-MA) to validate the involvement of autophagy in FST against APAP-induced hepatotoxicity in vitro. We demonstrated that FST prevented APAP-induced hepatotoxicity by increasing ATG5 expression, thereby promoting autophagy and inhibiting inflammasome activation.

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Section: Introductionmentioning

confidence: 99%

Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy

Zhang

Zhao

et al. 2020

Front. Pharmacol.

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“…1, 2, and 3). Other natural CRMs, such as butein and fisetin (11,21,27,38,48,53,58,59), also inhibited T-cell activation (IC 50 = 2.8 μM and 5.2 μM, respectively) ( Figs. 1 and 3).…”

Section: Resultsmentioning

confidence: 94%

T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics

et al. 2019

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Caloric restriction (CR) is a major contributor to good health and longevity. CR mimetics (CRMs) are a group of plant-derived compounds capable of inducing the benefits of CR. Since a longevity gene, SIRT1, inhibits T-cell activation and SIRT1 loss results in increased T-cell activation, we hypothesized that compounds capable of activating SIRT1 signaling can inhibit T-cell activation and function as CRMs. Thus we propose, in the present study, the application of a T-cell activation-inhibitory assay to screen candidate CRMs. Well-known CRMs, such as resveratrol, butein, and fisetin, suppressed the anti-CD3/CD28 antibody-induced activation of mouse spleen T-cells. We next randomly assessed 68 plant-derived compounds for screening novel candidate CRMs using this bioassay and found that all four compounds showing IC 50 values <5 μM, such as curcumin, α-mangostin, nobiletin, and heptamethoxyflavone, have beneficial functions for health such as anti-inflammatory effect. These results suggest that the T-cell activation-inhibitory assay can be used to screen candidate CRMs.

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“…The antioxidant and anti‐inflammatory properties of fisetin found in the present study are consistent with previous reports in which fisetin was shown to curtail oxidative stress and inflammation, albeit in different pathological conditions and in different experimental systems. For example, fisetin protected aging‐induced rat brain degeneration by suppressing oxidative stress, inflammation, and apoptosis (Singh et al, ). Recently, fisetin was shown to impart beneficial effects in non‐alcoholic fatty liver disease in male albino rats by the suppression of oxidative stress (Gaballah, El‐Horany, & Helal, ).…”

Section: Discussionmentioning

confidence: 99%

“…For example, fisetin protected aging-induced rat brain degeneration by suppressing oxidative stress, inflammation, and apoptosis (Singh et al, 2018). Recently, fisetin was shown to impart beneficial effects in non-alcoholic fatty liver disease in male albino rats by the suppression of oxidative stress (Gaballah, El-Horany, & Helal, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…The pathology of COPD involves increased oxidative stress and inflammation, leading to lung injury, and cigarette smoking is apparently related to increased COPD risk. The antioxidant and anti-inflammatory activities of fisetin under different pathological conditions have been previously reported (Kim, Lee, & Yun, 2017;Kim, Kim, & Yun, 2012;Kwak, Ku, & Bae, 2014;Maurya & Trigun, 2016;Singh, Singh, Garg, & Rizvi, 2018). However, the capacity of fisetin to block oxidative stress and inflammation induced by a powerful pro-oxidant such as CS has not been tested.…”

Section: Introductionmentioning

confidence: 99%

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The plant flavonoid, fisetin alleviates cigarette smoke‐induced oxidative stress, and inflammation in Wistar rat lungs

et al. 2019

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In the present study, we tested the antioxidant and anti‐inflammatory potential of the plant flavonoid, fisetin against cigarette smoke‐induced oxidative stress, and inflammation in rat lungs. Male Wistar rats were chronically exposed to cigarette smoke (CS) with or without administration of fisetin. Fisetin administration to CS‐exposed rats resulted in a significant reduction in neutrophils and macrophages in bronchoalveolar lavage fluid as well as malondialdehyde, 3‐nitrotyrosine, 8‐isoprostane, tumor necrosis factor‐alpha, interleukin‐1beta, granulocyte macrophage‐colony stimulating factor, interleukin‐4, and interleukin‐10 levels in lung tissues compared to those in CS‐exposed rats not treated with fisetin. Fisetin also significantly augmented lung hemoxinase‐1, glutathione peroxidase‐2, reduced glutathione, superoxide dismutase, nitric oxide, and nuclear factor erythroid 2‐related factor (Nrf2) levels in CS‐exposed rats. In addition, a marked reversal in CS‐induced histopathological changes was noted in fisetin‐treated rats. Collectively, these data demonstrate the potential of fisetin to blunt CS‐induced oxidative stress and inflammation in the lung and to prevent tissue damage via the Nrf2‐mediated upregulation of antioxidant gene expression. Practical applications In the present study, we found that the plant flavonoid, fisetin significantly abrogated the oxidative stress, inflammation, and tissue damage induced by cigarette smoke, a powerful pro‐oxidant in rat lungs. Additionally, fisetin markedly reversed cigarette smoke‐induced increases in neutrophil and macrophage cell populations in bronchoalveolar lavage fluid. These findings are particularly significant considering the association of cigarette smoking with increased oxidative stress and inflammation, which are central to the pathologies of a wide variety of chronic diseases including chronic obstructive pulmonary disease, cancer, and cardiovascular diseases. Therefore, the present work underscores the beneficial effects of the regular consumption of plant‐based foods with medicinal properties for the effective prevention of these chronic diseases.

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Fisetin as a caloric restriction mimetic protects rat brain against aging induced oxidative stress, apoptosis and neurodegeneration

Cited by 109 publications

References 61 publications

Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy

Fisetin Prevents Acetaminophen-Induced Liver Injury by Promoting Autophagy

T-cell activation-inhibitory assay: a proposed novel method for screening caloric restriction mimetics

The plant flavonoid, fisetin alleviates cigarette smoke‐induced oxidative stress, and inflammation in Wistar rat lungs

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