Fish oil extracted from <i>Coregonus peled</i> improves obese phenotype and changes gut microbiota in a high-fat diet-induced mouse model of recurrent obesity

Qin, Ningbo; Song, Guoku; Ren, Xiaomeng; Zhang, Lihua; Gao, Jie; Xia, Xiaodong; Zhu, Beiwei

doi:10.1039/d0fo00911c

Cited by 13 publications

(12 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have demonstrated that marine unsaturated lipids can positively regulate the gut microbiota of rats. [ 31 ] In line with previous studies, the dominant bacteria of the samples were Bacteroidetes and Firmicutes . [ 32–34 ] The family Bacillariophyceae is thought to be associated with obesity, fatty liver, and intestinal health because of metabolic processes associated with butyric and acetic acids in species and families of microorganisms of this bacterium.…”

Section: Discussionsupporting

confidence: 83%

Egg Yolk Phospholipids Modulate Microbial Imbalance in the Intestinal Tract of Rats on a High‐Fructose Diet

Yin¹,

Zhang²,

Tang

et al. 2021

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

High‐fructose diet (HFD), a cause of excessive obesity and destruction of the structure of the intestinal ecosystem, has become a common eating habit. This study aims to explore the effect and mechanism of egg yolk phospholipids (EPLs) on improving obesity, intestinal short‐chain fatty acids (SCFAs), and intestinal bacterial structure in rats induced by HFD. Results indicate that EPLs exhibit better effects on anti‐obesity than those of soy phospholipids (SPLs). EPLs increase the reduction of SCFAs caused by HFD, increased acetic acid, propionic acid, isobutyric acid, and total SCFAs, which effectively regulate the environment of intestinal microbial metabolism. Moreover, EPLs decrease Firmicutes/Bacteroides ratio (F/B) and the relative abundance of Streptomyces, Arthrobacter, and Desulfovibrio, and increase the relative abundance of Mucilaginibacter and Cellulomonas. These results suggest that EPLs have a potential modulating effect on intestinal disorders caused by HFD. Practical Applications: The results of this study illustrate that phospholipids are a promising supplement to alleviate the intestinal flora disorder caused by a high‐fructose diet, and its protective effect is mainly to regulate the composition of intestinal short‐chain fatty acids.

show abstract

Section: Discussionsupporting

confidence: 83%

Egg Yolk Phospholipids Modulate Microbial Imbalance in the Intestinal Tract of Rats on a High‐Fructose Diet

Yin¹,

Zhang²,

Tang

et al. 2021

Euro J Lipid Sci & Tech

View full text Add to dashboard Cite

show abstract

“…The variable V3/4 region of 16 S rRNA gene was amplified with following primers 319F (5′-ACTCCTACGGGAGGCAGCAG-3′) and 806R (5′-GGACTACHVGGGTWTCTAAT-3′). The PCR products were purified with AMPure XP beads (Beckman Coulter, Indianapolis, IN), quantified by the PicoGreen dsDNA assay kit, and sequenced using Illumina HiSeq 4000 with 2 × 300 bp paired-end reads as previous reported method [ 22 ]. For operational taxonomic units (OTUs), nucleotide sequence with 97% identity was assigned to the same OTUs based on SILVA128 database.…”

Section: Methodsmentioning

confidence: 99%

Dietary Acrylamide Intake Alters Gut Microbiota in Mice and Increases Its Susceptibility to Salmonella Typhimurium Infection

Wang

Liu

et al. 2021

Foods

Self Cite

View full text Add to dashboard Cite

Acrylamide (AA) has been extensively examined for its potential toxicological effects on humans and animals, but its impacts on gut microbiota and effects on hosts’ susceptibility to enteric infection remain elusive. The present study was designed to evaluate the effect of AA on gut microbiota of mice and susceptibility of mice to S. Typhimurium infection. After four weeks’ intervention, mice fed with AA exhibited significantly decreased body weight. Meanwhile, 16S rRNA gene sequencing showed reduced relative abundance of Firmicutes and increased abundance of Bacteroidetes in AA-treated mice prior to infection. In addition, we observed high relative abundance of Burkholderiales and Erysipelotrichales, more specifically the genus Sutterella and Allobaculum, respectively, in AA-treated mice before infection. Subsequently, the mice were orally infected with S. Typhimurium. The histological changes, systemic dissemination of S. Typhimurium, and inflammatory responses were examined. Compared to mice fed with normal diet, mice fed AA exhibited higher level of bacterial counts in liver, spleen, and ileum, which was consistent with exacerbated tissue damage determined by histological analyses. In addition, higher expression of pro-inflammaroty cytokines, p-IκBα, and p-P65 and lower mRNA expressions of mucin2, occludin, zo-1, claudin-1, and E-cadherin were detected in AA-treated mice. These findings provide novel insights into the potential health impact of AA consumption and the detailed mechanism for its effect on S. Typhimurium infection merit further exploration.

show abstract

“…Diet supplementation with fish-derived oil containing omega 3 fatty acids has been shown to possess beneficial effects in diabetes and obesity [ 13 ]. Different types of extracts from fish have been tested for beneficial action on obesity and type 2 diabetes, such as tuna-derived extracts through boiling [ 14 ], Tapra fish-derived fish oil [ 15 ], or ethanol extracts from Masou salmon [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity

et al. 2021

View full text Add to dashboard Cite

Metabolic syndrome-related diseases affect millions of people worldwide. It is well established that changes in nutritional habits and lifestyle can improve or prevent metabolic-related pathologies such as type-2 diabetes and obesity. Previous reports have shown that nutritional supplements have the capacity to limit glucose intolerance and suppress diabetes development. In this study, we investigated the effect of dietary supplementation with fish-derived extracts on obesity and type 2 diabetes and their impact on gut microbial composition. We showed that nutritional supplements containing Fish Complex (FC), Fish Complex combined with Cod Powder (FC + CP), or Cod Powder combined with Collagen (CP + C) improved glucose intolerance, independent of abdominal fat accumulation, in a mouse model of diet-induced obesity and type 2 diabetes. In addition, collagen-containing supplements distinctly modulate the gut microbiome in high-fat induced obesity in mice. Our results suggest that fish-derived supplements suppress diet-induced type 2 diabetes, which may be partly mediated through changes in the gut microbiome. Thus, fish-derived supplements and particularly the ones containing fish collagen have potential beneficial properties as dietary supplements in managing type 2 diabetes and metabolic syndrome via modulation of the gut microbiome.

show abstract

Fish oil extracted from Coregonus peled improves obese phenotype and changes gut microbiota in a high-fat diet-induced mouse model of recurrent obesity

Abstract: The potential modulatory effect of fish oil from Coregonus peled on recurrent obese mice by influencing persistent microbiome alterations.

Cited by 13 publications

References 49 publications

Egg Yolk Phospholipids Modulate Microbial Imbalance in the Intestinal Tract of Rats on a High‐Fructose Diet

Egg Yolk Phospholipids Modulate Microbial Imbalance in the Intestinal Tract of Rats on a High‐Fructose Diet

Dietary Acrylamide Intake Alters Gut Microbiota in Mice and Increases Its Susceptibility to Salmonella Typhimurium Infection

Diet Supplementation with Fish-Derived Extracts Suppresses Diabetes and Modulates Intestinal Microbiome in a Murine Model of Diet-Induced Obesity

Contact Info

Product

Resources

About