Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats

Liaset, Bjørn; Madsen, Lise; Qin, Hao; Criales, Gabriel; Mellgren, Gunnar; Marschall, Hanns‐Ulrich; Hallenborg, Philip; Espe, Marit; Frøyland, Livar; Kristiansen, Karsten

doi:10.1016/j.bbalip.2009.01.016

Cited by 109 publications

(111 citation statements)

References 63 publications

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“…However, since it is possible that APP induces qualitative changes in muscle such as fiber type, lipid metabolism, and carbohydrate metabolism, further investigations are needed to elucidate these possibilities. It has been reported that fish protein hydrolysate in a saithe, which is a white fish like Alaska pollack, elevates serum bile acids and reduces visceral body fat (11), and that serum bile acids enhance energy expenditure by promoting intracellular thyroid hormone activation and reduce visceral body fat (16,17). Thus, we examined whether or not APP intake increases serum bile acids, but found no such effect in the present study.…”

Section: Discussionmentioning

confidence: 63%

Fast-twitch muscle hypertrophy partly induces lipid accumulation inhibition with Alaska pollack protein intake in rats

et al. 2010

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Fish protein is a source of animal protein that is consumed worldwide. Although it has been reported that the intake of Alaska pollack protein (APP) reduces serum triglyceride and body fat accumulation in rats, the mechanisms underlying these effects are poorly understood. In the present study, we fed 5-week-old male Sprague-Dawley rats a high-fat diet with APP or casein for 4 weeks. We reconfirmed that the intake of APP decreases serum triglycerides and inhibits visceral body fat accumulation in rats. We found that APP had a higher non-digestive protein content than casein, and the amount of protein in feces was higher in the APP group than in the casein group. However, the amount of total lipids in feces did not differ significantly between the groups. We also found that the gastrocnemius muscle, a fast-twitch muscle, tended to increase in weight, and that the epididymal fat weight correlated negatively with gastrocnemius muscle weight in the APP group. These results imply that the enhancement of basal energy expenditure by fast-twitch muscle hypertrophy, rather than the enhancement of lipid excretion via feces, partly causes APP-induced inhibition of lipid accumulation in rats.

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Section: Discussionmentioning

confidence: 63%

Fast-twitch muscle hypertrophy partly induces lipid accumulation inhibition with Alaska pollack protein intake in rats

et al. 2010

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“…The antioxidative properties exhibited by meat/fish protein hydrolysates are mainly due to the several endogenous antioxidants present in skeletal muscle (Table 1). Fish protein hydrolysate is known not only to elevate plasma bile acids, reduce visceral adipose tissue mass in rats (Liaset et al 2009) but also reported to truncate the increased intestinal permeability in humans (Marchbank et al 2008). It is also reportedly known to reduce the symptoms of occasional diarrhoea and constipation, and alleviated bloating (Englender 2000).…”

Section: Meat Incorporated Foodmentioning

confidence: 99%

Characteristics and consumer acceptance of healthier meat and meat product formulations—a review

et al. 2011

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“…Concomitantly, bile flow and taurocholate excretion were induced in experiments with perfused rat livers (29). In rats fed low fat diets, we have previously shown that BA metabolism can be modulated by dietary proteins with different endogenous glycine and taurine contents (30).…”

mentioning

confidence: 99%

Nutritional Regulation of Bile Acid Metabolism Is Associated with Improved Pathological Characteristics of the Metabolic Syndrome

Liaset¹,

Qin

Jørgensen

et al. 2011

Journal of Biological Chemistry

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Bile acids (BAs) are powerful regulators of metabolism, and mice treated orally with cholic acid are protected from dietinduced obesity, hepatic lipid accumulation, and increased plasma triacylglycerol (TAG) and glucose levels. Here, we show that plasma BA concentration in rats was elevated by exchanging the dietary protein source from casein to salmon protein hydrolysate (SPH). Importantly, the SPH-treated rats were resistant to diet-induced obesity. SPH-treated rats had reduced fed state plasma glucose and TAG levels and lower TAG in liver. The elevated plasma BA concentration was associated with induction of genes involved in energy metabolism and uncoupling, Dio2, Pgc-1␣, and Ucp1, in interscapular brown adipose tissue. Interestingly, the same transcriptional pattern was found in white adipose tissue depots of both abdominal and subcutaneous origin. Accordingly, rats fed SPH-based diet exhibited increased whole body energy expenditure and heat dissipation. In skeletal muscle, expressions of the peroxisome proliferatoractivated receptor ␤/␦ target genes (Cpt-1b, Angptl4, Adrp, and Ucp3) were induced. Pharmacological removal of BAs by inclusion of 0.5 weight % cholestyramine to the high fat SPH diet attenuated the reduction in abdominal obesity, the reduction in liver TAG, and the decrease in nonfasted plasma TAG and glucose levels. Induction of Ucp3 gene expression in muscle by SPH treatment was completely abolished by cholestyramine inclusion. Taken together, our data provide evidence that bile acid metabolism can be modulated by diet and that such modulation may prevent/ameliorate the characteristic features of the metabolic syndrome.

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Fish protein hydrolysate elevates plasma bile acids and reduces visceral adipose tissue mass in rats

Cited by 109 publications

References 63 publications

Fast-twitch muscle hypertrophy partly induces lipid accumulation inhibition with Alaska pollack protein intake in rats

Fast-twitch muscle hypertrophy partly induces lipid accumulation inhibition with Alaska pollack protein intake in rats

Characteristics and consumer acceptance of healthier meat and meat product formulations—a review

Nutritional Regulation of Bile Acid Metabolism Is Associated with Improved Pathological Characteristics of the Metabolic Syndrome

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