Fitoquímica e quimiossistemática de Conchocarpus marginatus e C. inopinatus (Rutaceae)

Abstract

Recebido em 10/5/12; aceito em 18/9/12; publicado na web em 26/10/12 PHYTOCHEMICAL AND CHEMOSYSTEMATICS STUDIES OF Conchocarpus marginatus AND C. inopinatus (Rutaceae). Phytochemical studies of the leaves and stem have led to the identification of the known acridone alkaloids arborinine, methylarborinine, 1-hydroxy-3-methoxy-N-methyl acridone, xanthoxoline, 1,2,3,5-tetramethoxy-N-methylacridone, toddaliopsin C and the new seco acridone alkaloid inopinatin. The known quinoline alkaloids 2-phenyl-1-methyl-quinolin-4(1H)-one, 2-phenyl-1-methyl-7-methoxy-quinolin-4(1H)-one, dictamnine, and the coumarins scopoletin and marmesin were also isolated. The isolated compounds and the distribution of secondary metabolites, which are systematically important, obtained from literature, clearly confirmed that some species formerly described in the genera Angostura and Galipea in fact shall belong to the genus Conchocarpus.

Targeted Isolation of Indolopyridoquinazoline Alkaloids from Conchocarpus fontanesianus Based on Molecular Networks

“…The antifungal agents were identified as flindersine ( 17 ) and 8-methoxyflindersine ( 18 ), furoquinoline alkaloids previously described in other members of the Rutaceae family but never reported in the genus Conchocarpus . Both compounds exhibited a similar minimal inhibitory quantity (MIQ) of 15 μg against the C. albicans -sensitive mutant strain DSY2621, but were inactive against a wild strain of this yeast.…”

“…Two acridone alkaloids were isolated from Conchocarpus paniculatus , with flavonoids, alkaloids, and steroids reported in C. heterophyllus and alkaloids and amides from C. gaudichaudianus . Phytochemical investigation of leaves and stems of C. marginatus and C. inopinatus have led to the identification of coumarins and acridone and quinoline alkaloids …”

Structural Elucidation by NMR Analysis Assisted by DFT Calculations of a Novel Natural Product from Conchocarpus Mastigophorus (Rutaceae)

“…The final spectra were generated using the Boltzmann average (based on Gibbs free energies) of the lowest-energy conformers identified for (3S)-1 a and plotted using Origin 8 software. (10), 84 (100), 82 (44), 80 (5), 70 (16), 69 (5), 68 (6), 67 (13), 57 (34), 56 (12), 55 (28), 54 (13), 53 (8). a ½ � 23 D À 0.021 (c 0.0483, methanol).…”

“…Acridone alkaloids are natural products typical of the family Rutaceae and one of the most common alkaloids of the genus Conchocarpus [9] . In the literature, there are some examples of plant species of the genus Conchocarpus with acridone alkaloids, namely: C. marginatus ; C. inopinatus , [6] C. coeruleus ; C. rubrus [10] and C paniculatus [11] . It is important to emphasize that some of those plants were known by other names before a reclassification; for example, Conchocarpus marginatus was previously known as Angostura paniculate , [12] while Conchocarpus rubrus and Conchocarpus coeruleus belonged to the extinct genus Almeidea [13] .…”

“…An example of a plant with great research potential is Conchocar-pus mastigophorus Kallunki, which belongs to the Rutaceae family and is endemic to Brazil. [3] In recent years, researchers have highlighted the wide chemical constitution of some of the Conchocarpus plants, pointing out that the major secondary metabolites found are alkaloids, [4] coumarins, [5] flavonoids, [6] and terpenes. [7] However, more than forty of the fifty-two known species of Conchocarpus, [8] including C. mastigophorus Kallunki, have never been studied for a better understanding of their chemical and biological potential.…”