Fitting a Double-Exponential Curve to Observed Salicylate Concentrations in Blood

Mueller, F.W.; Lieberman, S.V.

doi:10.1002/jps.2600590415

Cited by 13 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Each curve was analysed in terms of a bi-exponential function by the methods of residuals using a digital computer program. The fit chosen was that which minimized the logarithms of squared deviations between experimental and computed values (Mueller & Lieberman, 1970 CV) C0 r-L E E Q i% the function were similar to those determined from plasma data (see Table 5). After portal vein administration.…”

Section: Resultsmentioning

confidence: 99%

The Pharmacokinetics of Neostigmine and 3‐hydroxyphenyltrimethylammonium in the Rat: Dose‐dependent Effects After Portal Vein Administration

Barber

Bourne

1974

British J Pharmacology

View full text Add to dashboard Cite

The elimination kinetics of [14C]‐neostigmine iodide and [14C]‐3‐hydroxyphenyltrimethylammonium iodide (3‐OH PTMA) have been studied in the rat. The presence of a renal secretory pathway for neostigmine and 3‐OH PTMA has been confirmed. For neostigmine and 3‐OH PTMA, at a given dose level, the fraction of the dose eliminated unchanged was reduced and the metabolite fraction was increased after portal vein administration when compared to jugular vein administration. This indicates that both compounds are subject to extensive metabolism during the first passage through the liver. Neostigmine was eliminated by dose‐independent kinetics after jugular vein administration but dose‐dependent after portal vein administration. In the latter case the fraction eliminated as neostigmine increased with increasing dose. This increase was not accompanied by any change in the fraction of the metabolites eliminated. After portal vein administration of 3‐OH PTMA, the fraction of the dose eliminated as 3‐OH PTMA also increased with increasing dose. This change was accompanied by a decrease in the fraction of the metabolites eliminated which were excreted at a constant rate.

show abstract

Section: Resultsmentioning

confidence: 99%

The Pharmacokinetics of Neostigmine and 3‐hydroxyphenyltrimethylammonium in the Rat: Dose‐dependent Effects After Portal Vein Administration

Barber

Bourne

1974

British J Pharmacology

View full text Add to dashboard Cite

show abstract

“…In each instance, the residual sums of squares between the experimental points and the computed curves were calculated. 6 There was (Table 111) illustrate the rapid phase of elimination from plasma (T/2 = 0.54 to 1.92 min) , and the subsequent slower decline in concentration (T/2 = 24.23 to 45.00 min). CIearIy, the present analysis cf the plasma concentration data in terms of a biexponential function of time has conceptuallimitations, since the possibility of a third component after 60 min cannot be excluded.…”

Section: Plasma Clearance Of Edrophonium In Manmentioning

confidence: 99%

Plasma concentration of edrophonium in man

Calvey

Williams

Muir

et al. 1976

Clin Pharma and Therapeutics

View full text Add to dashboard Cite

The plasma concentration of edrophonium was measured in man after intravenous administration. In 5 patients, the clearance of edrophonium from the circulation during the 1-hr period of sampling was invariably resolved into 2 exponential components. An initial rapid phase of elimination from plasma (T/2 = 0.54 TO 1.92 Min) was followed by a much slower decline (T/2 = 24.23 to 45.00 Min), corresponding to the fall in concentration between 10 and 60 min. In parallel experiments in the rat, the clearance of 14C-edrophonium was resolved into 3 exponential components, although the final component could not be reliably defined until 1 to 3 hr after intravenous injection. It is suggested that the rapid fall in the plasma concentration of edrophonium in both species is not dependent on metabolism or excretion, but is due to the rapid uptake of the drug by the liver and kidneys.

show abstract

Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics

Bernardo¹,

Russo²

1969

Journal of Pharmaceutical Sciences

View full text Add to dashboard Cite

Fitting a Double-Exponential Curve to Observed Salicylate Concentrations in Blood

Cited by 13 publications

References 6 publications

The Pharmacokinetics of Neostigmine and 3‐hydroxyphenyltrimethylammonium in the Rat: Dose‐dependent Effects After Portal Vein Administration

The Pharmacokinetics of Neostigmine and 3‐hydroxyphenyltrimethylammonium in the Rat: Dose‐dependent Effects After Portal Vein Administration

Plasma concentration of edrophonium in man

Pharmaceutical Sciences—1968. A Literature Review of Pharmaceutics

Contact Info

Product

Resources

About